Help With Test Results

[Quaylern]

Hello

I am new to this world of gluten intolerance and I was hoping some of you with more experience can help me with my test results. My Genova Diagnostics Celiac and Gluten Sensitivity results are as follows:

Total IgA 219

Anti-tissue Transglutaminase IgA <1.2 (negative)

Anti-deamidated Gliadin IgA 4 (negative)

Anti-Gliadin IgA 52 (strong positive)

Anti-Gliadin IgG 50 (strong positive)

The little interpretation chart points to gluten intolerance, not celiac but from what I gather from what I have read is that it could still possibly be Celiac. I have considered having the genetic testing but I'm unsure if I should since it is a considerable out of pocket expense and the treatment would be the same, a gluten free diet.

Also, I have a 5 year old daughter and made an appointment for her to have the saliva test done. Any experience with the reliability of this test, especially in young children? I can feed her gluten free at home but unfortunately, I am divorced and it would take a positive test to possibly convince my ex husband that a gluten free diet and even then I am worried that he won't take it seriously.

Any information or advice is hugely appreciated!

Thank you!

Rheanna

[frieze]

do you have the endoscopy scheduled?

[Quaylern]

I don't have an endoscopy scheduled. I wasn't sure how or if I should proceed with more tests.

[nvsmom]

The AGA IgA and AGA IgG can indicate non celiac gluten sensitivity (NCGS) but the tests have a specificity of 80-95% for celiac disease, so chances are good that the positive results are caused by celiac disease and not NCGS. This report is where I found the info (page 12): Open Original Shared Link

I agree that if you want to know whether it is celiac disease or NCGS, then the endoscopy might be a good idea. Just be aware that doctors can miss the damaged spots - false negatives are possible although a minority.

Either result will result in the same treatment - 100% gluten-free diet for life. Hope you feel well soon.

[Quaylern]

The AGA IgA and AGA IgG can indicate non celiac gluten sensitivity (NCGS) but the tests have a specificity of 80-95% for celiac disease, so chances are good that the positive results are caused by celiac disease and not NCGS. This report is where I found the info (page 12): Open Original Shared Link

I agree that if you want to know whether it is celiac disease or NCGS, then the endoscopy might be a good idea. Just be aware that doctors can miss the damaged spots - false negatives are possible although a minority.

Either result will result in the same treatment - 100% gluten-free diet for life. Hope you feel well soon.

Thank you so much for this information. I found it very helpful. I have been on a gluten free diet for the last week and a half and I am ready feeling better. If I chose to ask my doctor for an ednoscopy, do I need to be eating gluten? I know I would need to for the blood tests but wasn't sure if it would be ok to do the endoscopy soon, while on a gluten free diet and have the endoscopy have the most accurate results as possible.

Thank you for your help!

[nvsmom]

You're welcome.

Yes, you have to be eating gluten for an accurate endoscopic biopsy. Most doctors seem to require a two week gluten challenge prior to testing but some advise eating gluten a month before testing. Talk to your doctor as soon as you can about the biopsy, but I am guessing that you will need to resume eating gluten soon if your test is in the near future.

Good luck.