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is this a negative test result?


RachelEBooker

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RachelEBooker Newbie

I have been visiting a GI doctor for my constant stomach pain. He took blood tests and today I received on of a celiac disease panel... and I am so confused. I can't find anything online that gives layman terms. 

test results.webp


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tessa25 Rising Star

Your TTG IGA is less than 2. That test says no celiac. Your IGA is 148 and is normal. So the first test is a good test.

There are other tests for celiac. A positive on any one of them would mean you should get an endoscopy/biopsy to verify celiac. Those tests are:

TTG IGG

DGP IGA

DGP IGG

EMA

CYA: I'm not a doc

RachelEBooker Newbie
25 minutes ago, tessa25 said:

Your TTG IGA is less than 2. That test says no celiac. Your IGA is 148 and is normal. So the first test is a good test.

There are other tests for celiac. A positive on any one of them would mean you should get an endoscopy/biopsy to verify celiac. Those tests are:

TTG IGG

DGP IGA

DGP IGG

EMA

CYA: I'm not a doc

Ok thanks so much for answering. I was freaking out because I couldn't understand it and the doctor is closed already. I had never thought I had celiac but when I looked up the symptoms I was even more worried because I have them all. 

squirmingitch Veteran

This paper does not show the entire celiac panel, just a small part of it. Do you know if they did more than what is on the paper?

RachelEBooker Newbie
14 minutes ago, squirmingitch said:

This paper does not show the entire celiac panel, just a small part of it. Do you know if they did more than what is on the paper?

This is all that I have. I wasn't even aware I was being tested for Celiac. He told me he needed to take blood to make sure I was digesting and absorbing nutrients properly and to run a battery of tests. I assume this is just a part of the tests that were performed. 

cyclinglady Grand Master

Learn more about celiac disease testing here:

Open Original Shared Link

This talks about celiac disease and the risks of developing it (e.g. Already having an autoimmune disorder or a family member with celiac disease):

Open Original Shared Link

The TTG test is a good test, but it does not catch all celiacs (I always test negative to the TTG).    If you and your GI still suspect celiac disease, you should get the DGP and EMA tests.  Since you are not IgA deficient, the IgA versions should be fine.  Note that some celiacs are seronegative (no antibodies).  If celiac disease is ruled out FOR SURE, you might be gluten sensitive, but not have intestinal damage.  This is called Non-Celiac Gluten Intolerance.  The "cure" is a gluten free diet (like celiac disease).  

This algorithm goes over testing:

Open Original Shared Link

Your doctor may order an endoscopy to check for other things like SIBO, ulcers, H. Pylori, etc.  he may want to check for celiac disease anyway (you could be seronegative).  In any case, do NOT settle!  Something is wrong!  

RachelEBooker Newbie
6 minutes ago, cyclinglady said:

Learn more about celiac disease testing here:

Open Original Shared Link

This talks about celiac disease and the risks of developing it (e.g. Already having an autoimmune disorder or a family member with celiac disease):

Open Original Shared Link

The TTG test is a good test, but it does not catch all celiacs (I always test negative to the TTG).    If you and your GI still suspect celiac disease, you should get the DGP and EMA tests.  Since you are not IgA deficient, the IgA versions should be fine.  Note that some celiacs are seronegative (no antibodies).  If celiac disease is ruled out FOR SURE, you might be gluten sensitive, but not have intestinal damage.  This is called Non-Celiac Gluten Intolerance.  The "cure" is a gluten free diet (like celiac disease).  

This algorithm goes over testing:

Open Original Shared Link

Your doctor may order an endoscopy to check for other things like SIBO, ulcers, H. Pylori, etc.  he may want to check for celiac disease anyway (you could be seronegative).  In any case, do NOT settle!  Something is wrong!  

Ugh, now I am back to square one. I was thinking 'whew, no celiac disease.' Now i can't be sure. What I think I will do is start removing gluten from my diet and see if it helps. 


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cyclinglady Grand Master

Sorry, I saw that the EMA test was run and it was negative.  Still, I personally tested negative to that one as well.  Talk to your doctor first before going gluten free.  You need to be on a gluten diet for even the endoscopy/biopsies to work.  He still might want to do the endoscopy to rule out other issues.  If everything is okay, then consider the gluten-free diet.  

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    • par18
      Thanks for the reply. 
    • Scott Adams
      What you’re describing is actually very common, and unfortunately the timing of the biopsy likely explains the confusion. Yes, it is absolutely possible for the small intestine to heal enough in three months on a strict gluten-free diet to produce a normal or near-normal biopsy, especially when damage was mild to begin with. In contrast, celiac antibodies can stay elevated for many months or even years after gluten removal, so persistently high antibody levels alongside the celiac genes and clear nutrient deficiencies strongly point to celiac disease, even if you don’t feel symptoms. Many people with celiac are asymptomatic but still develop iron and vitamin deficiencies and silent intestinal damage. The lack of immediate symptoms makes it harder emotionally, but it doesn’t mean gluten isn’t harming you. Most specialists would consider this a case of celiac disease with a false-negative biopsy due to early healing rather than “something else,” and staying consistently gluten-free is what protects you long-term—even when your body doesn’t protest right away.
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      Yes, I meant if you had celiac disease but went gluten-free before screening, your results would end up false-negative. As @trents mentioned, this can also happen when a total IGA test isn't done.
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