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Inadequate Explaination of Test Results


Jeb02840

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Jeb02840 Newbie

Hello Everyone!

A little background history, about 4 years ago, I was diagnosed with Hypothyroidism and Hashimoto's Disease.  I had half of my thyroid removed due to an irregular biopsy.  No cancer, but a plethora of daily meds for the rest of my life!   My Endocrynologist ran a full comprehensive blood test and it showed that I was anemic as well as my liver functions were low.  She recommended that I visit my PCM and have him check both of them more extensively.  

Well, I did go visit my PCM, and he ran a Celiac Panel and a Ferritin test.  The Ferritin came back slightly anemic but my hemoglobin levels were fine!  However....my Celiac Panel came back with what seems to me to be a mess.  My Gliadin Ab IgG is 160 higher than normal, Gliadin Ab IgA is 234 higher than normal, my tissue transglutaminase Ab IgG is normal at 2 but my  tissue transglutaminase Ab IgA is >100 higher than normal and my IgA is normal at 258.   His nurse called me this afternoon and told me that my results "indicated" celiacs and that I was being referred to a Gastroenterologist as well as a nutritionist.  "Indicated", could you please be a bit more descript?????  Can anyone enlighten me as to what these results actually mean???  Do I have Celiacs?  And I Gluten Intolerant, or have a gluten intolerance???   This is just so frustrated?!?!


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tessa25 Rising Star

You failed three celiac tests with flying colors assuming normal is < 20. Indicated you have celiac (in my opinion) means you have celiac. A high on anyone celiac test should mean you go to a gastroenterologist  for an endoscopy/biopsies to confirm the celiac diagnosis and see how bad the damage is.

You should keep eating gluten until the endoscopy.

CYA: I am not a doc

RMJ Mentor

Many doctors will not give a firm celiac diagnosis without an endoscopy/biopsy.  I think that is why you were told your results “indicated” celiac instead of being told you have celiac.  With those antibody results it would be very surprising if the biopsy does not show celiac.

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    • Scott Adams
      If your tTg-IgA was 28 and positive is at 3, you are nearly 10x over the positive marker, so the most likely explanation by far would be celiac disease. I also do not understand why your doctor would not want to run the blood test, which is the normal first step in the diagnosis process.
    • xxnonamexx
      Is there a digestive enzyme that helps build a healthier gut? I see people taking them but not sure what really works
    • trents
      So the tTG-IGA at 28 is positive for celiac disease. There are some other medical conditions that can cause elevated tTG-IGA but this is unlikely. There are some people for whom the dairy protein casein can cause this but by far the most likely cause is celiac disease. Especially when your small bowel lining is "scalloped". Your Serum IGA 01 (aka, "total IGA") at 245 mg/dl is within normal range, indicating you are not IGA deficient. But I also think it would be wise to take your doctor's advice about the sucraid diet and avoiding dairy . . . at least until you experience healing and your gut has had a chance to heal, which can take around two years. After that, you can experiment with adding dairy back in and monitor symptoms. By the way, if you want the protein afforded by dairy but need to avoid casein, you can do so with whey protein powder. Whey is the other major protein in dairy.
    • jenniber
      hi, i want to say thank you to you and @trents   . after 2 phone calls to my GI, her office called me back to tell me that a blood test was “unnecessary” and that we should “follow the gold standard” and since my biopsy did not indicate celiac, to follow the no dairy and sucraid diet. i luckily have expendable income and made an appt for the labcorp blood test that day. i just got my results back and it indicates celiac disease i think 😭   im honestly happy bc now i KNOW and i can go gluten free. and i am SO MAD at this doctor for dismissing me for a simple blood test that wouldn’t have cost her anything !!!!!!!!!!! im sorry, im so emotional right now, i have been sick my whole life and never knew why, i feel so much better already   my results from labcorp:   Celiac Ab tTG TIgA w/Rflx Test Current Result and Flag Previous Result and Date Units Reference Interval t-Transglutaminase (tTG) IgA 01 28 High U/mL 0-3 Negative 0 - 3 Weak Positive 4 - 10 Positive >10 Tissue Transglutaminase (tTG) has been identified as the endomysial antigen. Studies have demonstrated that endomysial IgA antibodies have over 99% specificity for gluten sensitive enteropathy. Immunoglobulin A, Qn, Serum 01 245 mg/dL 87-352
    • JoJo0611
      Thank you this really helped. 
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