Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Enzymes not a forbidden word anymore


docaz

Recommended Posts

docaz Collaborator

I have been working with enzymes for many years and until recently, most celiacs cringed when they heard the word "enzymes".  That is clearly changing. Now you can even see on the Stanford University celiac page under the highlighted innovation section that enzymes can prevent an inflammatory reaction. 

https://stanfordhealthcare.org/medical-clinics/celiac-disease-program.html


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



RMJ Mentor

I wish they had given more information so I could read their publications on enzymes.

docaz Collaborator
9 minutes ago, RMJ said:

I wish they had given more information so I could read their publications on enzymes.

This is a description of the enzymes by one of the most prominent celiac researcher there is https://www.healio.com/news/gastroenterology/20170831/latiglutenase-improves-symptoms-in-celiac-disease

A follow up study is being planned and patients are being recruited. 

This is the underlying patent that explains how the enzyme combination of two complementing enzymes work

https://patents.google.com/patent/US8796201B2/en

The DSM product that I am working with (GliadinX) has the same action but it is achieved with one enzyme rather than two and is complemented by the natural stomach enzymes. 

 It is interesting because I am in the medical field and usually people are excited about new treatment modalities even if they are in an investigation phase. In the celiac world the pessimism and skepticism is astonishing. 

This enzyme combination was developed by a clinician at Stanford and they have a lot of background research that was done without being published. 

Even if enzymes are not a cure but a way to manage the disease, the implications for the lifestyle of celiac patients is unimaginable. 

RMJ Mentor

Thank you so much!  I am in the medical/pharmaceutical field and am definitely interested since my celiac antibodies are supersensitive but my symptoms aren’t.  I’m hoping GliadinX can help with the gluten contamination I’m getting somewhere and get those antibody levels back to normal.

docaz Collaborator
8 minutes ago, RMJ said:

Thank you so much!  I am in the medical/pharmaceutical field and am definitely interested since my celiac antibodies are supersensitive but my symptoms aren’t.  I’m hoping GliadinX can help with the gluten contamination I’m getting somewhere and get those antibody levels back to normal.

 

9 minutes ago, RMJ said:

Thank you so much!  I am in the medical/pharmaceutical field and am definitely interested since my celiac antibodies are supersensitive but my symptoms aren’t.  I’m hoping GliadinX can help with the gluten contamination I’m getting somewhere and get those antibody levels back to normal.

My children were in a similar situation. They were pretty much asymptomatic but they were incidentally diagnosed because of the high antibodies. They had the entire celiac panel, genetic test and endomysial test. 

On a gluten-free diet the numbers went down but when they started taking the enzymes then numbers went completely normal and we know that they have been exposed to gluten. 

I had the luxury to be able to spend an enormous amount of time connecting with the specialists in the field and invested a good amount of resources to help my children and while effort is not always rewarded, in this situation it was and as a result they live much easier lives. They stayed asymptomatic and their antibody levels have stayed in the low normal range for the last 7 or so years.  

Since you are in the medical field, this publication which is not an easy read for most will make sense to you

https://www.mdpi.com/2072-6643/12/7/2095/pdf

This is the doctoral thesis that I discussed with the forme head of the University of Chicago Celiac center before giving my children enzymes and that really convinced me to meet the researchers and I was fortunate to get a batch of enzymes years before they became available on the market.

This publication is a doctoral thesis and very long but goes over a lot of material that was put together very well at one of the oldest universities in Europe https://openaccess.leidenuniv.nl/handle/1887/17698

 

RMJ Mentor

Thank you! Reading material while sheltering at home from COVID.

docaz Collaborator
17 minutes ago, RMJ said:

Thank you! Reading material while sheltering at home from COVID.

I hope that the COVID thing will resolve before you finish reading it. 


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      129,761
    • Most Online (within 30 mins)
      7,748

    LisaNY
    Newest Member
    LisaNY
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121.2k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • knitty kitty
      Oh, @MagsM, Sorry you had that happen with Niacin.  500mg is the maximum amount of Niacin one should take.  Niacin works hand in hand with Thiamine, so a big influx like that can imbalance thiamine if not supplemented at the same time.  All the B vitamins work together in concert.  Niacin in doses at 500 mg or above have been used by doctors to lower triglycerides levels and raise HDL, the good cholesterol.  Pharmaceuticals to do the same thing are more expensive and thus more profitable for physicians. Has your doctor tested you for H. Pylori?  An infection by H. Pylori can be tested for by your doctor.  H. Pylori can cause low tTg IgA results, too.   I would hold off on the microbiome test for now.  Your microbiome is going to change when you go gluten free.  Your microbiome will change when you start taking Thiamine.  Thiamine supplementation influences which microbes grow in the intestines, encouraging beneficial bacteria and getting rid of the bad ones.  Thiamine in the form Benfothiamine promotes intestinal healing, too.  Adopting the Autoimmune Protocol Diet (by Dr. Sarah Ballantyne, a Celiac herself) after diagnosis will also change your microbiome.  This is the best diet to heal and recover, IMO.   If you're going to have more testing done for vitamin deficiencies, don't take vitamin supplements beforehand, otherwise the tests will measure the vitamin supplements in your bloodstream and give false results.  Same thing will happen if you take B vitamin shots.  The supplements you mentioned (Arterosil HP and Vascanox HP) are herbal support and do not contain all eight B vitamins.  There's no harm in taking them, but I prefer a B Complex that contains all the B vitamins in activated forms like Life Extension's Bioactive Complete B Complex.  All the B vitamins work together in concert.  Magnesium is important to supplement as thiamine and magnesium make life sustaining enzymes together.  Do not buy supplements containing Thiamine Mononitrate because it is not biologically active.  It is very hard for the body to utilize.  Most of it (70%) passes out unused.    Yes, my Meniere's disease has not returned.  I was deficient in Vitamin D.  I took high doses of Vitamin D 3 to correct the deficiency quickly.  I also took TTFD (tetrahydrofurfuryl disulfide) which is a form of thiamine different from Benfotiamine.  TTFD can cross the blood brain barrier without a carrier, so it can get into the brain very easily.  TTFD helps the Vagus nerve function.  The Vagus nerve regulates the ears and balance, and also the digestive system.  I like Allithiamine by Ecological Formulas.  I also like Thiamax by Objective Nutrients.  You should have improvements within a hour with TTFD.  TTFD is much stronger, so lower doses will give amazing benefits (50-200 mg).   I hope this helps give you some direction to take on your journey!
    • MagsM
      Thank you so much for this in depth analysis. I am currently taking Vit D3/K2 5000IU daily.i started taking a flushing Niacin but foolishly took a 500mg tab and nearly passed out! I have just ordered a gut microbiome genome test and it will be interesting to see what my current balance of microbes are. After I finish diagnosis I will definitely go gluten free. Diagnosis will inform exactly how strict I’ll need to be regarding cross contamination etc. my focus will be on healing the gut. I have also been focusing on the oral microbiome - cutting out FL and using more natural products as well as daily oil pulling. I read from some of your other forum entries about Benfothiamine and I’ll definitely order that. I’ll make sure my doc orders more detailed vitamin and mineral panel plus total IGA as well as the DGP-IGA and DGP-IGG tests. We will see if I can get the endoscopic biopsy done. Do you think I should request Vitamin B shots to get me started?  My daily vitamin protocol will likely be VitD/K2 5000IU, Benfothiamin 300x2, Niacin (flushing) 50mg working up to 300mg. I also take a EPA/DHA as well as some vascular support (Arterosil HP and Vascanox HP) as well as Magnesium at night. Which B complex brand do you like? I will see what the gut microbiome test comes back with. I’m sure they will try to sell me pre/probiotics and maybe some digestive enzymes. What are you thought on those? I’m curious if you managed to go into full remission from your Ménière’s disease? Thank you so much for your thoughtful insight. I know that building back up my gut health and immune health will help in so many ways as well as protecting me from many other major diseases as I go into my 60s and beyond. 
    • Scott Adams
      You are right! The logo the have on their packages got me confused--it looks like they are less than 20ppm, not certified GF. Thanks for catching that! My brain also zeroed in on this "less than 10ppm" but I should have seen the rest...
    • Wheatwacked
      Zinc glyconate lozenges (Cold Eeze) helps fight off viral respiratory infections by coating the mucous membrane cells to protect them from virus.  Zinc is an antiviral essential mineral. Choline deficieicy can be the cause of Non Alcoholic Fatty Liver Disease.  It is estimated by some experts that less than 10% eat the minimum RDA of around 450 mg.  It has also been connected to gallbladder disease.  Brain fog and high homosystein blood level is an independant indicator of cardiovascular disease. Eggs and red meat are the primary sources.  Three eggs or 10 cups of cooked brocolli a day.  Low vitamin D is a common denominator of autoimmune disease.  Is it a contributing factor or a result? I think that low vitamin D is maybe the main contributing factor.  Low vitamin D allows the immune system to run amuck. I would like to point out the many diagnosed with Celiac Disease went through several misdiagnoses, like gall bladder disease, and were repeatedly tested negative and then one day tested positive. Regardless of your diagnosis, you should avoid gluten, you mention it in your first post : "When I eat gluten I get a lot of mucus with my stool and most of the times it’s quite thin. As soon as I take gluten away from my diet my stool becomes normal". It can take six months to several years to heal completely.  How long I believe is directly related to how quickly you identify deficiencies and correct. Essential to my recovery:  Thiamine, 10,000 IU vitamin D3 a day, maintaining 25(OH)D at 80 ng/dl (200 nmole/L), 600 mcg Liquid Iodine, Phosphatidyl Choline.  And of course: Gluten Free.
    • RMJ
      Not all of King Arthur’s gluten free flours and baking mixes are certified gluten free. This bread flour is not. 
×
×
  • Create New...