Gliadin (deamidated) antibody, IgA blood work

[Dean M]

Gliadin (deamidated) antibody, IgA blood work has not come down to normal after 15 months of being on a gluten-free diet. Does any else have this problem?

 

[trents]

Can you give us the specific IGA test or tests you are referring to as well as the actual numbers of the most recent test results and the negative-positive reference ranges for the tests used by the lab? And how old is your son? Is he still consuming dairy and or oats?

Edited March 9, 2022 by trents

[Dean M]

2 hours ago, trents said:

Can you give us the specific IGA test or tests you are referring to as well as the actual numbers of the most recent test results and the negative-positive reference ranges for the tests used by the lab? And how old is your son? Is he still consuming dairy and or oats?

Deamidated Gliadin Abs, Iga   =  76 High     range 0-19,  is part of a Celiac Antibody Profile of my blood test. Last test was 2-23-22 and every test has been in the 70's for 15 months now. My          t-Transglutaminase (tTG) IgG  = 4    Range 0-5, came down to normal after 3 months being on gluten-free diet. The test is for me and yes I consume dairy and only eat gluten free oats.

[trents]

Sorry about the "son" thing. I was replying to another thread at the same time where that was the context.

The centerpiece of IGA testing for celiac disease is the tTG-IGA, which I don't see listed in your posted results. I only see tTG-IGG. The tests that have been run for you suggest you may have low total IGA. The tests you list are also more commonly run for young children who often have low total IGA counts.

https://blog.healthmatters.io/2021/05/22/what-is-deamidated-gliadin-abs-iga-igg-from-celiac-comprehensive-panel-description-interpretation/

https://celiac.org/about-celiac-disease/screening-and-diagnosis/screening/

Cross contamination of oats with gluten containing grains is not the only problem with oats. Some celiacs react to the oat protein itself (avenin) in the same way they do gluten. Also, many celiacs react to the protein casein in dairy the same way they do to gluten.

[Dean M]

8 minutes ago, trents said:

Sorry about the "son" thing. I was replying to another thread at the same time where that was the context.

The centerpiece of IGA testing for celiac disease is the tTG-IGA, which I don't see listed in your posted results. I only see tTG-IGG. The tests that have been run for you suggest you may have low total IGA. The tests you list are also more commonly run for young children who often have low total IGA counts.

https://blog.healthmatters.io/2021/05/22/what-is-deamidated-gliadin-abs-iga-igg-from-celiac-comprehensive-panel-description-interpretation/

https://celiac.org/about-celiac-disease/screening-and-diagnosis/screening/

Cross contamination of oats with gluten containing grains is not the only problem with oats. Some celiacs react to the oat protein itself (avenin) in the same way they do gluten. Also, many celiacs react to the protein casein in dairy the same way they do to gluten.

The doctor tells me I am gluten sensitive and it my be causing my neuropathy. He referred me to this web site for help if needed. Here is my first blood work and last blood work (see below). I can not get a good answer from doctor why my Deamidated Gliadin Abs, IgA will not come down, so here I am.

I just started eating gluten-free oat meal about 30 days ago but have been eating /drinking dairy all long.

Thanks so much for your reply and help.

 

Celiac Disease Comprehensive blood work: 1-21-21
--Deamidated Gliadin Abs, IgA 77 High, Negative 0 - 19,Weak Positive 20 - 30, Moderate to Strong Positive >30
--Deamidated Gliadin Abs, IgG 8, Negative 0 - 19, Weak Positive 20 - 30, Moderate to Strong Positive >30
--t-Transglutaminase (tTG) IgA <2, Negative 0 - 3, Weak Positive 4 - 10, Positive >10

--t-Transglutaminase (tTG) IgG 10 High, Negative 0 - 5, Weak Positive 6 - 9, Positive >9
--Immunoglobulin A, Qn, Serum 192, referance 90-386

 

Celiac Disease Comprehensive blood work: 2-24-22

--Immunoglobulin A, Qn, Serum 01 192, referrence 90-386

--Deamidated Gliadin Abs, IgA  76, Negative 0 - 19, Weak Positive 20 - 30, Moderate to Strong Positive >30
--Deamidated Gliadin Abs, IgG  2, Negative 0 - 19, Weak Positive 20 - 30, Moderate to Strong Positive >30
--t-Transglutaminase (tTG) IgA  <2, Negative 0 - 3, Weak Positive 4 - 10, Positive >10

--t-Transglutaminase (tTG) IgG  5, Negative 0 - 5, Weak Positive 6 - 9, Positive >9
 

 

 

[trents]

Okay, thanks for the additional info.

I note that your tTG-IGA is within normal range. This is the centerpiece of celiac antibody testing and considered to combine the best test as it combines good sensitivity with good specificity. Other tests are strong in one area and weak in the other. The tTG-IGA can give false negatives when the total IGA (Immunoglobulin A) is low. Your total IGA is not low at 192.

There are people who do have celiac disease who throw negatives for the tTG-IGA because they have an atypical immune system response and that is why other tests are sometimes run when there are persistent celiac disease symptoms present. Neuropathy can be one of them.

But you mention that your doctor things you may have gluten sensitivity. That term encompasses celiac disease but also NCGS (Non Celiac Gluten Sensitivity). There is no test for the latter. Celiac disease must first be ruled out by either antibody blood tests or an endoscopy with biopsy of the small bowel lining. NCGS is 10x more common than celiac disease. They have a lot of the same symptoms.

[Dean M]

1 hour ago, trents said:

Okay, thanks for the additional info.

I note that your tTG-IGA is within normal range. This is the centerpiece of celiac antibody testing and considered to combine the best test as it combines good sensitivity with good specificity. Other tests are strong in one area and weak in the other. The tTG-IGA can give false negatives when the total IGA (Immunoglobulin A) is low. Your total IGA is not low at 192.

There are people who do have celiac disease who throw negatives for the tTG-IGA because they have an atypical immune system response and that is why other tests are sometimes run when there are persistent celiac disease symptoms present. Neuropathy can be one of them.

But you mention that your doctor things you may have gluten sensitivity. That term encompasses celiac disease but also NCGS (Non Celiac Gluten Sensitivity). There is no test for the latter. Celiac disease must first be ruled out by either antibody blood tests or an endoscopy with biopsy of the small bowel lining. NCGS is 10x more common than celiac disease. They have a lot of the same symptoms.

Thanks for the info. I had an endoscopy done and the biopsy came back negative.  Been on a strict gluten-free diet and have not gotten any better with the neuropathy but also have not gotten any worse. Just trying to figure out what to do next.

[trents]

1 minute ago, Dean M said:

Thanks for the info. I had an endoscopy done and the biopsy came back negative.  Been on a strict gluten-free diet and have not gotten any better with the neuropathy but also have not gotten any worse. Just trying to figure out what to do next.

So, putting all this information together I wonder if your neuropathy is not gluten related.

[Dean M]

7 minutes ago, trents said:

So, putting all this information together I wonder if your neuropathy is not gluten related.

Not sure but not ready to give up on a gluten-free diet. 

[Dean M]

1 minute ago, Dean M said:

Not sure but not ready to give up on a gluten-free diet. 

That's why I was wondering if the Deamidated Gliadin Abs, IgA being still high had anything to with my problem with gluten.

[trents]

11 minutes ago, Dean M said:

That's why I was wondering if the Deamidated Gliadin Abs, IgA being still high had anything to with my problem with gluten.

You seem to be assuming you have a problem with gluten. Besides the neuropathy, do you have other symptoms that could be gluten related?

And here is an important question: When you had your initial testing done fro celiac disease, both the antibody test and the biospy, were you already on a gluten free diet? If so, you sabotaged the testing.

Edited March 9, 2022 by trents

[Dean M]

22 minutes ago, trents said:

You seem to be assuming you have a problem with gluten. Besides the neuropathy, do you have other symptoms that could be gluten related?

And here is an important question: When you had your initial testing done fro celiac disease, both the antibody test and the biospy, were you already on a gluten free diet? If so, you sabotaged the testing.

The neurologist performed the blood test and sent me to the GI doctor. The GI doc said I was gluten sensitive and performed the biospy. Then I started the gluten-free diet. I do not have any other symptoms that is gluten related. 

[trents]

The fact that eating gluten-free has not made any significant changes in your blood antibody numbers together with no improvement in your neurological problems after 15 months strongly suggests to me that gluten may not be your problem.

[Scott Adams]

Your initial tests on 1-21-21 definitely indicate that you have celiac disease. Looking at the 2nd test results, it is possible that you're getting small amounts of contamination often enough that you're hindering your recovery. I agree with @trents and you should eliminate oats as well. This article may be helpful:

 

[trents]

Yes, now that I look at the results from 1/21/21 more closely there is strong positive for Deamidated Gliadin Abs and a positive (barely) for tTG-IGG. But the tTG-IGA is negative. Still, not a typical celiac disease antibody result profile I'm thinking.

[Dean M]

21 hours ago, Scott Adams said:

Your initial tests on 1-21-21 definitely indicate that you have celiac disease. Looking at the 2nd test results, it is possible that you're getting small amounts of contamination often enough that you're hindering your recovery. I agree with @trents and you should eliminate oats as well. This article may be helpful:

 

Do oats mimic gluten in our body? What other foods mimic gluten in my body? 

[trents]

1 hour ago, Dean M said:

Do oats mimic gluten in our body? What other foods mimic gluten in my body? 

The oat protein avenin must be similar enough to gluten that it triggers the same autoimmune response that gluten does in the small bowel for some celiacs. Dairy is another common gluten mimicar for some celiacs.

There are also some medications that blunt the villi.

Edited March 10, 2022 by trents