SIBO and increased IEl with moderate atrophy of intestinal villi

[Matt13]

Hi all,

Are there any of you here who have this kind of histological finding Intraepithelial lymphocytosis with hyperplasia of the crypts and moderate atrophy of intestinal villi plus SIBO positive test METHANE? 

Kind regards

[Scott Adams]

The findings you mentioned from an endoscopy, specifically intraepithelial lymphocytosis with hyperplasia of the crypts and moderate atrophy of intestinal villi, could indicate that you have celiac disease.

Intraepithelial lymphocytosis refers to an increased number of lymphocytes (a type of immune cell) within the lining of the small intestine. Hyperplasia of the crypts refers to the expansion or enlargement of the crypts of Lieberkühn, which are small invaginations within the lining of the intestine. These changes can be observed microscopically during an endoscopy with biopsies.

Additionally, the moderate atrophy of intestinal villi suggests that the finger-like projections called villi, which aid in nutrient absorption, have become flattened or damaged. This atrophy leads to reduced surface area and impaired absorption of nutrients from food.

It's important to note that these findings are not definitive proof of celiac disease, and a diagnosis should be confirmed through additional tests such as blood tests to detect specific antibodies associated with celiac disease (e.g., anti-tissue transglutaminase antibodies). 

You will need to keep eating gluten daily until all tests are completed, and here is more info on celiac disease blood testing, which is typically done before an endoscopy:

 

[ForwardMotion]

Hi Matt - I also have celiac, and SIBO-Methane.  Please read up on the fine work of Mark Pimentel, MD of Cedars-Sinai and Alison Siebecker, ND on how to effectively test and recover from small intestinal bacteria overgrowth (SIBO).  I am currently taking two doctor-prescribed antibiotics:  Rifaximin and Metronidazole.  Low FODMAP diet helps too as well as avoiding all carbs including gluten-free for a period of time.  Dr. Siebecker recommends a diet that combines both the Low FODMAP Diet and Specific Carbohydrate Diet.  SIBO is a chronic condition and I hope that you have found a good doctor who will help you with this.  - Sue

[cnazrael89]

I also was diagnosed in October 2022 with Celiac and now a few days ago was tested for SIBO and was positive for Hydrogen SIBO. I was tested due to ongoing celiac-like symptoms yet I am very careful with gluten free diet. I have now been told to take Doxycycline 100mg twice a day for 21 days, do a low FODMAP diet for 2 weeks and then do probiotics for 2 weeks after antibiotics are done. Hoping this treatment will clear it up! Hoping for a speedy, successful SIBO recovery for you all as well!