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5 Htp


covsooze

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covsooze Enthusiast

I've read a little bit about 5 HTP and its benefits for depression and sleep problems and wondering if anyone's got any good / bad experiences of using it. Does it interact with any other meds? (don't know whether I should wait until I'm totally off my ads to try it).


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plantime Contributor

My husband uses it with no problems. He didn't think it was working, but I noticed a difference!

TERESE Rookie
I've read a little bit about 5 HTP and its benefits for depression and sleep problems and wondering if anyone's got any good / bad experiences of using it. Does it interact with any other meds? (don't know whether I should wait until I'm totally off my ads to try it).

I've been taking 50 mgs of 5-HTP every evening for a year now. I had a lot of trouble staying asleep. I also take 1/4 of a 50 mg trazodone so I'm not sure which one is helping but I sleep like a rock now. Slept through a really bad rain storm a few night ago. I haven't had any trouble with 5-HTP.

eleep Enthusiast

I used to take it as a supplement back at a time when I was a bit more of a partyer and doing things that were depleting my body -- it seemed to work wonders for recovery at the time.

sparkles Contributor

What is 5 HTP?

skbird Contributor

I've taken between 25 and 50 mg a day - was fine. I didn't notice it changing my sleep other than more vivid dreams, and I did notice about half the time my mood was improved. I was thinking recently about going on it again.

Since it is a precurser to serotonin and we make nearly half our serotonin in our gut, wouldn't it make sense that it would help a recovering Celiac? Especially with depression.

The only potential issues I've heard of involve taking 5HTP with antidepressants or the triptan migraine pills because they all relate to serotonin issues. I don't know if there is an actual problem taking them together, but something to research for sure, since both of those drugs have an effect on how your body reacts to serotonin - taking a supplement that turns into serotonin might be an issue.

Stephanie

Nancym Enthusiast

I think this is an excellent resource for reading up on supplements: Open Original Shared Link

Open Original Shared Link


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trents Grand Master
I've been taking 50 mgs of 5-HTP every evening for a year now. I had a lot of trouble staying asleep. I also take 1/4 of a 50 mg trazodone so I'm not sure which one is helping but I sleep like a rock now. Slept through a really bad rain storm a few night ago. I haven't had any trouble with 5-HTP.

Terese,

I was Just reading your bio at the bottom of your post. Is your hemoglobin and hematocrit high without the B12 injections? I assume you are taking the B12 injections because you have pernicious anemia.

Steve

utdan Apprentice

I tried it a few years ago and didn't notice any difference, but that was before I went gluten free.

covsooze Enthusiast

Thanks all. Nancy, that link was very useful :) I liked it because it seemd to give a very balanced picture.

TERESE Rookie
Terese,

I was Just reading your bio at the bottom of your post. Is your hemoglobin and hematocrit high without the B12 injections? I assume you are taking the B12 injections because you have pernicious anemia.

Steve

Steve, yes my hemoglobin and hematocrit are high with out the B12 injections and I've just had my blood tested again after being on the B12 for 4 months and it's still high, no change. The dr's note on the test says "probably due to low B12 & B6." I have never been told I have pernicious anemia. Do you have a clue what this means? I see others on the board have pernicious anemia. I always feel like I'm overloaded with questions and answers at the Dr's. I really like her but sometimes feel rushed.

Thanks

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    • Scott Adams
      This is a very common question, and the most important thing to know is that no, Guinness is not considered safe for individuals with coeliac disease. While it's fascinating to hear anecdotes from other coeliacs who can drink it without immediate issues, this is a risky exception rather than the rule. The core issue is that Guinness is brewed from barley, which contains gluten, and the standard brewing process does not remove the gluten protein to a level safe for coeliacs (below 20ppm). For someone like you who experiences dermatitis herpetiformis, the reaction is particularly significant. DH is triggered by gluten ingestion, even without immediate gastrointestinal symptoms. So, while you may not feel an instant stomach upset, drinking a gluten-containing beer like Guinness could very well provoke a flare-up of your skin condition days later. It would be a gamble with a potentially uncomfortable and long-lasting consequence. Fortunately, there are excellent, certified gluten-free stouts available now that can provide a safe and satisfying alternative without the risk.
    • MogwaiStripe
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    • Butch68
      Before being diagnosed coeliac I used to love Guinness. Being made from barley it should be something a coeliac shouldn’t drink. But taking to another coeliac and they can drink it with no ill effects and have heard of others who can drink it too.  is this everyone’s experience?  Can I drink it?  I get dermatitis herpetiformis and don’t get instant reactions to gluten so can’t try it to see for myself. 
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    • Scott Adams
      I will assume you did the gluten challenge properly and were eating a lot of gluten daily for 6-8 weeks before your test, but if not, that could be the issue. You can still have celiac disease with negative blood test results, although it's not as common:  Clinical and genetic profile of patients with seronegative coeliac disease: the natural history and response to gluten-free diet: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606118/  Seronegative Celiac Disease - A Challenging Case: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441776/  Enteropathies with villous atrophy but negative coeliac serology in adults: current issues: https://pubmed.ncbi.nlm.nih.gov/34764141/  Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.
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