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Why Get A Biopsy?

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elye Community Regular
elye
Posted

We also had a rare experience with a very with-it GP. My dad has had celiac symptoms for years, and he recently had inconclusive blood test results. When he questioned his family doc about having a biopsy, the doc said, "your intestinal tract is twenty-two feet long. Chances are excellent that tiny samples taken from it, even if there are many, will not show damage. There's just too much there to get a full picture". And he proceeded to recommend the gluten-free diet as a diagnostic. Why aren't there more of them like that? :)

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Guest nini
Guest nini
Posted

Vincent, I LOVE your explanation! That's brilliant!

My personal opinion is that the biopsy is too risky, when you can simply TRY the gluten-free diet and see if it helps. You don't have to commit to it permanently if it doesn't help you, but give it a good effort, at least six months. It does NOT have to be expensive, in fact the way I do the diet for me and my daughter, our grocery bill is actually cheaper. I buy very few of the specialty products, but the ones I do buy, I portion them out and freeze things so that they last a lot longer.

Ok, so the biopsy can only confirm IF positive. The diet doesn't have to be expensive, you don't have to commit to it permanently IF IT DOESN'T HELP. But if it does help, you've saved yourself from a costly and potentially risky surgical procedure. You don't need a Dr.s permission to go gluten-free. If you do not have a diagnosis of Celiac on your permanent record, you won't have to worry about being denied health insurance because of a pre existing condition (and before anyone says "oh that doesn't happen, IT HAPPENED TO ME.) Don't trust me. Trust yourself.

Helena Contributor
Helena
Posted

I'm dealing with this very question right now, and I've found the conversation in this thread to be very helpful. Thanks :D

jukie Rookie
jukie
Posted

The positive labs were enough for me, but I have a family history of colon, stomach, and intestinal cancer (coincidence...I think not). Anyway, because of the family history and years of chronic illness, I went ahead with the endoscopy/colonoscopy for my own peace of mind. In the meantime, I'm having my 4 year old tested with Enterolab and will NOT allow an endoscopy for him regardless of the results.

  • 2 weeks later...
KaitiUSA Enthusiast
KaitiUSA
Posted

I don't recommend biopsies because they can rule celiac in but not out. The only reason to get a biopsy would be possibly to see how much if any damage has occured so far into it.

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      heaps of hope!

      By wellthatsfun · Posted

      i know i've been rather cynical and sad about being fully diagnosed in june 2025, but my boyfriend has been consistently showing me the wonderful world that is gluten free cooking and baking. in the past couple of days he's made me a gluten free rice paper-wrapped spanakopita "pastry", plus a wonderful mac and cheese bechamel-ish sauce with gluten free pasta (san remo brand if you're in australia/if you can get your hands on it wherever you are).  those meals are notably gluten free, but mainly he's been making me easy gluten free meals - chili mince with white rice and sour cream, chicken soup with homemade stock from the chicken remains, and roast chickens with rice flour gravy and roast veggies. i'm a bit too thankful and grateful lol. how lucky could i possibly be? and, of course, for those who don't have someone to cook for them, it's quite easy to learn to cook for yourself. i've been making a lot of meals for us too. honestly, cooking is pretty darn fun! knowing basic knife skills and sanitary practices are all you really need. experimenting with spices will help you get on track to creating some really flavourful and yummy dishes. coeliac is a pain, but you can use it to your advantage. healthier eating and having fun in the kitchen are major upsides. much luck to all of you! let's be healthy!
    • knitty kitty
      Help understand results

      By knitty kitty · Posted

      That test is saying that your daughter is not making normal amounts of any IGA antibodies.  She's not making normal amounts of antibodies against gliadin, not against bacteria, not against viruses.  She is deficient in total IGA, so the test for antigliadin antibodies is not valid.  The test was a failure.  The test only works if all different kinds of antibodies were being made.  Your daughter is not making all different kinds of antibodies, so the test results are moot.  Your daughter should have the DGP IgG and TTG IgG tests done.   The tests should be performed while she is still consuming gluten.  Stopping and restarting a gluten containing diet can make her more sick, just like you refuse to eat gluten for testing.  Call the doctor's office, request both the IGG tests. Request to be put on the cancellation list for an appointment sooner.  Ask for genetic testing.   Celiac disease is passed on from parents to children.  You and all seven children should be tested for genes for Celiac disease.  Your parents, your siblings and their children should be tested as well.  Eating gluten is not required for genetic testing because your genes don't change.  Genetic testing is not a diagnosis of Celiac disease.  Just having the genes means there is the potential of developing Celiac disease if the Celiac genes are activated.  Genetic testing helps us decide if the Celiac genes are activated when coupled with physical symptoms, antibody testing, and biopsy examination. It's frustrating when doctors get it wrong and we suffer for it.  Hang in there.  You're a good mom for pursuing this!  
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    • trents
      Positive biopsy

      By trents · Posted

      Welcome to the celiac.com community @pothosqueen!   Can you be more specific about which IGA test was run that resulted in 114 score and said to be "normal" and could you please include the reference range for what would be normal? By the size of that number it looks like it may have been what we call "total IGA" but that test is not usually run without also running a TTG-IGA. Total IGA tests for IGA deficiency. If someone is IGA deficient, then the celiac-specific IGA tests like the TTG-IGA will be inaccurate. Was this the only IGA test that was run? To answer, your question, yes, a positive biopsy is normally definitive for celiac disease but there are some other medical conditions, some medications and even some food proteins in rare cases that can cause positive biopsies. But it is pretty unlikely that it is due to anything other than celiac disease.
    • pothosqueen
      Positive biopsy

      By pothosqueen · Posted

      Upper endoscopy last week resulted in positive biopsy for celiac disease. The IgA they ran was normal (114). Does positive biopsy automatically mean definitive diagnosis?
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