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Confused About Something


jasonD2

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jasonD2 Experienced

Ok so i understand antibodies to gluten can damage the intestines, well, what about other foods? if you're sensitive to casein or soy or corn could antibodies to these also destroy the villi? based on what i've read it seems that only gluten does tha,t but it doesnt make sense to me. so you can eliminate gluten from your diet but something else you're sensitive to can be causing problems?


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Guest j_mommy

From what I understand, yes if you are intolerant to other things they can cause damage as well!!!! At teh very least...slow the healing process after a person goes gluten-free!

happygirl Collaborator

Technically yes they can, but it is very, very rare.

Other foods can certainly cause symptoms, but very very few, and in very few individuals, do the foods actually cause villi blunting.

From a leading Celiac expert at Columbia University

Causes of villous atrophy apart from celiac disease

In children less than two years old, there are several causes that include cows milk allergy, soy allergy, eosinophillic gastroenteritis, and viral gastroenteritis. In adults, HIV enteropathy and tropical sprue are the most common causes of villous atrophy apart from celiac disease. Radiation may cause a similar picture as well as autoimmune enteropathy. Other food intolerances have been reported though are exceptionally rare; they include a single case report of fish and chicken intolerance.

nmw Newbie

I've been fanatically gluten-free for 17 months, developed issues with dairy, corn and soy this summer, had an EGD 3 weeks ago that showed villious blunting. I haven't had my follow-up yet, but will interrogate the dr. about this when I do. It's a good question and makes me wonder what they would have found had I requested the EGD when I went gluten-free.

JennyC Enthusiast

The antibodies do not blunt the villi, the T-cells do when they release cytokines when exposed to gluten. This is an autoimmune reaction. Food allergies and intolerances are different, but they do cause symptoms.

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    • Scott Adams
      This is a very common question, and the most important thing to know is that no, Guinness is not considered safe for individuals with coeliac disease. While it's fascinating to hear anecdotes from other coeliacs who can drink it without immediate issues, this is a risky exception rather than the rule. The core issue is that Guinness is brewed from barley, which contains gluten, and the standard brewing process does not remove the gluten protein to a level safe for coeliacs (below 20ppm). For someone like you who experiences dermatitis herpetiformis, the reaction is particularly significant. DH is triggered by gluten ingestion, even without immediate gastrointestinal symptoms. So, while you may not feel an instant stomach upset, drinking a gluten-containing beer like Guinness could very well provoke a flare-up of your skin condition days later. It would be a gamble with a potentially uncomfortable and long-lasting consequence. Fortunately, there are excellent, certified gluten-free stouts available now that can provide a safe and satisfying alternative without the risk.
    • MogwaiStripe
      Interestingly, this thought occurred to me last night. I did find that there are studies investigating whether vitamin D deficiency can actually trigger celiac disease.  Source: National Institutes of Health https://pmc.ncbi.nlm.nih.gov/articles/PMC7231074/ 
    • Butch68
      Before being diagnosed coeliac I used to love Guinness. Being made from barley it should be something a coeliac shouldn’t drink. But taking to another coeliac and they can drink it with no ill effects and have heard of others who can drink it too.  is this everyone’s experience?  Can I drink it?  I get dermatitis herpetiformis and don’t get instant reactions to gluten so can’t try it to see for myself. 
    • trents
      NCGS does not cause damage to the small bowel villi so, if indeed you were not skimping on gluten when you had the antibody blood testing done, it is likely you have celiac disease.
    • Scott Adams
      I will assume you did the gluten challenge properly and were eating a lot of gluten daily for 6-8 weeks before your test, but if not, that could be the issue. You can still have celiac disease with negative blood test results, although it's not as common:  Clinical and genetic profile of patients with seronegative coeliac disease: the natural history and response to gluten-free diet: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606118/  Seronegative Celiac Disease - A Challenging Case: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441776/  Enteropathies with villous atrophy but negative coeliac serology in adults: current issues: https://pubmed.ncbi.nlm.nih.gov/34764141/  Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.
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