Entro Lab Results.....i Am So Confused!

[dandt45]

I think a person has to be a doctor to understand these results. Can anyone tell me in simple words what all this means? Thank you so much for all your help and kindness.

LAB RESULTS FROM ENTRO LAB

A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value

Fecal Anti-gliadin IgA 183 Units (Normal Range <10 Units)

Fecal Anti-tissue Transglutaminase IgA 176 Units (Normal Range <10 Units)

Quantitative Microscopic Fecal Fat Score <300 Units (Normal Range <300 Units)

Fecal Anti-casein (cow's milk) IgA 184 Units (Normal Range <10 Units)

HLA-DQB1 Molecular analysis, Allele 1 0302

HLA-DQB1 Molecular analysis, Allele 2 0202

Interpretation of Fecal Anti-tissue Transglutaminase IgA: You have an autoimmune reaction to the human enzyme tissue transglutaminase, secondary to dietary gluten sensitivity.

Interpretation Of HLA-DQ Testing: HLA-DQB1 gene analysis reveals that you have one of the main genes that predisposes to gluten sensitivity and celiac sprue, HLA-DQB1*0201 or HLA-DQB1*0302. Each of your offspring has a 50% chance of receiving this gene from you, and at least one of your parents passed it to you. You also have a non-celiac gene predisposing to gluten sensitivity (any DQ1, DQ2 not by HLA-DQB1*0201, or DQ3 not by HLA-DQB1*0302). Having one celiac gene and one gluten sensitive gene, means that each of your parents, and all of your children (if you have them) will possess at least one copy of a gluten sensitive gene. Having two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity or celiac disease may be more severe.

[Jestgar]

A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value

Fecal Anti-gliadin IgA 183 Units (Normal Range <10 Units)

Fecal Anti-tissue Transglutaminase IgA 176 Units (Normal Range <10 Units)

Fecal Anti-casein (cow's milk) IgA 184 Units (Normal Range <10 Units)

HLA-DQB1 Molecular analysis, Allele 1 0302

HLA-DQB1 Molecular analysis, Allele 2 0202

Interpretation of Fecal Anti-tissue Transglutaminase IgA: You have an autoimmune reaction to the human enzyme tissue transglutaminase, secondary to dietary gluten sensitivity.

You are producing antibodies to gliadin, tissue transglutaminase and casein. None of these happen in "normal" people.

You are not excreting more than the normal amount of fat, so your intestines aren't too damaged (yet).

You also carry genes which are associated with gluten sensitivity.

[gfb1]

You are producing antibodies to gliadin, tissue transglutaminase and casein. None of these happen in "normal" people.

You are not excreting more than the normal amount of fat, so your intestines aren't too damaged (yet).

You also carry genes which are associated with gluten sensitivity.

'normal' is just a setting on the washing machine..

any 'normal' person would develop antibodies to gliadin, tissue transglutaminase (TTG) and casein (for that matter, bee stings and pork chops....) -- if those proteins were injected into their veins. the release of TTG is associated with the cell-death of intestinal enterocytes (and possibly other cells).

it is, however, certainly possible that some individuals are predisposed to be 'allergic' to wheat-derived peptides (such as gliadin), which would certainly result in gastrointestinal distress and possibly, in the long term, intestinal damage -- leading to other symptoms.

casein is an interesting case. casein, being a milk protein, is found in ALL mammals -- and allergies/responses can be species specific (e.g., commonly, human, sheep or goats milk is fine -- but, allergies exist to cows milk!). honestly, i'm very surprised that -- since an immune response is a secondary symptom of celiac disease (primary being inability to digest wheat gluten), that allergy testing has not taken on a larger role in diagnosis/treatment.

[nora-n]

Allergies are IgE mediated.

These tests here are IgA tests, and are true intolerances or immune reactions.

for example, interfereon treatment for Hepatitia, is pure IgA....IgE would not help.

Interpretation of the gene test:

You have HLA DQ8, teh other main celiac gene.

The other gene is HLA DQ2,2, a slightly predisposing celiac gene, (DQ2,5 is teh main celiac gene)

If you go back in teh postings here, you might find some more explanations on the gene issue.

YOur ttg-test is quite high, and you have a celiac gene, so I think you might also get a positive on an ordinary ttg-blood test. maybe just below the cutoff, as your fecal fat test is not high.

The blodo tests usually ordered by doctors:

Ttg both IgA and IgG versions

antigliadin IgA and IgG

endomysium antibdy test

Total IgA (just to check if the IgA tests are valid)

[Lisa]

-- since an immune response is a secondary symptom of celiac disease (primary being inability to digest wheat gluten)

gfb1 -

I am very intrigued by this statement. Would you kindly expand on this. Is this the sequence for Celiac Disease (autoimmune) as well, or an allergy (immune)?

[dandt45]

thank you all so much for your help. gees, this is very hard to understand. But what i have from this information is that i must follow a strict diet. Meat, Fruit and veggies. I have for the last three weeks and still have diarrhea, heart palps and very tired. how long before i get better? I work in a very stressful job (management) and can not miss anymore work. thank you so much for all your help

[Jestgar]

You might want to avoid raw fruits and veggies for a while. Give your digestive system a chance to rest. What are you eating? Post a couple days diet.