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Aga And Dgp Differences?

dhiltonlittle

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dhiltonlittle Contributor
dhiltonlittle
Posted

what is the difference between the AGA (IGA) anti gliadin antibody and the DGP deamidated gliadin pedtide antibody?

what exactly are they?

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Gemini Experienced
Gemini
Posted

what is the difference between the AGA (IGA) anti gliadin antibody and the DGP deamidated gliadin pedtide antibody?

what exactly are they?

This is covered in Dr. Peter Green's new book. The DGP is a newer version of the AGA test and, supposedly, a more sensitive test. I don't have the book with me so cannot provide a direct quote but that's essentially it. The AGA is still a good test but the DGP is better and may replace the AGA.

The AGA test looks for the gliadin protein in your blood, which happens if you are eating gluten and have Celiac Disease.

It is used to help diagnose and then used in re-testing to see if you are compliant to the diet.

sa1937 Community Regular
sa1937
Posted

I just received Dr. Green's new (revised) book today. This is what he says:

Deamidated Gliadin Peptides (DGP)

Patients with celiac disease create antibodies to gliadin, but these antibodies can also be found in other conditions and in normal people. It is known that tTG deamidates, that is , it acts on and enhances the gliadin peptide in patients with celiac disease which causes the inflammatory reaction in the gut. The new ELISA test looks for these specific antibodies to deamidated gliadin.

sa1937 Community Regular
sa1937
Posted

(cont'd) had an oops...

The new ELISA test looks for these specific antibodies to deamidated gliadin.

The DGP test is a significant and valuable new addition to the celiac panel. Many labs have changed over to it. It is also being studied to replace AGA antibody testing in young children who may not yet have developed tTG antibodies.

nora-n Rookie
nora-n
Posted

Interesting they admit that the ttg test is not good in small children...

Also, Dr. Ford writes about the deamidated gliadin antibody test on his website, google ford gluten.

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