Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Scientific Validation For Non-Celiac Gluten Sensitivity!

MsCurious

Recommended Posts

MsCurious Enthusiast
MsCurious
Posted

University of Maryland School of Medicine Researchers Identify Key Pathogenic Differences Between Celiac Disease & Gluten Sensitivity

Thursday, March 10, 2011

Open Original Shared Link

Dr. Alessio Fasano directs the Center for Celiac Rsearch.

"Scientists at the University of Maryland School of Medicine’s Center for Celiac Research have proven that gluten sensitivity is different from celiac disease at the molecular level and in the response it elicits from the immune system. The research, published online in BMC Medicine, provides the first scientific evidence of a different mechanism leading to gluten sensitivity. It also demonstrates that gluten sensitivity and celiac disease are part of a spectrum of gluten-related disorders."

MARCH 15, 2011 Clues to Gluten Sensitivity

Open Original Shared Link

"For the first time, we have scientific evidence that indeed, gluten sensitivity not only exists, but is very different from celiac disease," says lead author Alessio Fasano, medical director of the University of Maryland's Center for Celiac Research.

"There's a lot more that needs to be done for people with gluten sensitivity," she says. "But at least we now recognize that it's real and that these people aren't crazy."

Click the links for full stories... very interesting... most of it things we already knew... just nice to see the scientific medical community acknowledge these things! :)

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Igg postive Rookie
Igg postive
Posted

MsCurious, Excellent articles on Gluten Intolerance! The articles shows that the medical profession knows there is other gluten Intolerance in addition to Celiac Disease. I notice that one article said that the medical research for Gluten sensitivity is where medical research was for Celiac 30 years ago. That explains why there is no diagnosis and treatment for those negative to the blood tests and biopsy. I hope it doesn

MsCurious Enthusiast
MsCurious
Posted
  • Author

MsCurious, Excellent articles on Gluten Intolerance! The articles shows that the medical profession knows there is other gluten Intolerance in addition to Celiac Disease. I notice that one article said that the medical research for Gluten sensitivity is where medical research was for Celiac 30 years ago. That explains why there is no diagnosis and treatment for those negative to the blood tests and biopsy. I hope it doesn

missj Rookie
missj
Posted

This almost makes me want to canel my drs appointment on Thursday!!! It explains why it seems my system can handle small amounts but when I load up I feel horrid. I may or may not get answers in the coming months but now at least I know that there is someone out there, exploring the fact that this could be a spectrum type disorder. I'm still going to go ahead with my plan to ask for genetic testing first but if it comes back negative for Celiac, I still have at least some medical validation for me to do what I know I should do, whether I have the scopes done or not! Thanks so much for sharing this!

salexander421 Enthusiast
salexander421
Posted

I was very excited to read these articles!!

GFinDC Veteran
GFinDC
Posted

6% is a pretty large number of people. That should get some attention from researchers.

MsCurious Enthusiast
MsCurious
Posted
  • Author

6% is a pretty large number of people. That should get some attention from researchers.

LOL... Sorry for laughing but ... IMO the only money for research will come from gluten free food companies! :lol: The big pharmaceutical companies have zero interest in Gluten Intolerance and Celiac, because it is not treated with drugs, and people already know it can be successfully treated with diet. B)

University research, and independent research hospitals are the ones that have made attempts, but that has been limited, and certainly the findings are not reaching the general physican population. Sadly, that's the biggest gap right now... uneducated doctors. Hopefully, they will start taking more notice now! :)

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


GFinDC Veteran
GFinDC
Posted

LOL... Sorry for laughing but ... IMO the only money for research will come from gluten free food companies! :lol: The big pharmaceutical companies have zero interest in Gluten Intolerance and Celiac, because it is not treated with drugs, and people already know it can be successfully treated with diet. B)

University research, and independent research hospitals are the ones that have made attempts, but that has been limited, and certainly the findings are not reaching the general physican population. Sadly, that's the biggest gap right now... uneducatd doctors. Hopefully, they will start taking more notice now! :)

Oh, well, that should get some attention in a perfect world. But you are right, we don't live in one of them.

Well, 6% is enough to form a good size voting block anyway. Viva the gluten-free party! :)

  • 3 months later...
beachbirdie Contributor
beachbirdie
Posted

No money in it for big pharma means research WILL be difficult to fund. When I think back ten years ago to the time I was so sick I could not function, it was a nightmare getting anyone to take me and my thyroid symptoms seriously.My labs, after all, were "normal". No one bothered to look at my thyroid antibodies because my hormone levels were "fine".

Thankfully a person can discover for themselves whether gluten is a problem by simply avoiding it. You don't need a doc to do tests or write a prescription.

I tell everyone I know who has intestinal problems and docs that brush them off, that they should try taking gluten out of their diet.

paperbagprincess Rookie
paperbagprincess
Posted

I love this research article. Finally it tells everyone what we all knew! Hopefully they'll find some markers to help test those with sensitivity rather than celiac disease.

Lori2 Contributor
Lori2
Posted

6% is a pretty large number of people. That should get some attention from researchers.

The problem is that very few of the 6% have any clue that gluten might be the cause of their problems.

mushroom Proficient
mushroom
Posted

Either they don't know, or they are like one of my sisters and don't want to know because they can't tolerate the thought of giving up their precious gluten :P

melikamaui Explorer
melikamaui
Posted

FANTASTIC articles! I am passing these on to everyone I know. Good grief my friends are soooo sick of my Facebook updates about celiac disease, but I dont' care! These are just too good not to share. Thanks for posting them!

  • 2 months later...
jelina Newbie
jelina
Posted

I also was SO happy to read the study, since I don't have celiacs but I noticed a perhaps 80% improvement when I went off of gluten. (I tried going back on gluten a few times and those experiments utterly failed.)

The study also intrigued me because it appears that non-celiac gluten sensitive individuals had a different type of immune response, rather than just having a mini-form of celiacs. I'm no med student so I may have misunderstood the article, but something is messed up with the intestinal immune function.

I think this means that gluten sensitivity is just a manifestation of a deeper problem, especially as every non-celiac gluten sensitive person I met said they only felt about 80% better when they went off gluten. (I find it strange we all pick that number.) The interesting thing was that gluten sensitives had a lower Treg cell expression than the controls, and the celiacs didn't (with statistical significance). Couldn't this have implications for other types of immune responses, other than just to gluten?

I hope they continue with the research!

  • 1 year later...
peacefirst Rookie
peacefirst
Posted

I just read a book Healthier Without Wheat, and it says, that celiac is just one form of gluten intolerance, and not necessarily the most serious since some other froms can be very damaging to the body as well.

Lisa Mentor
Lisa
Posted

I just read a book Healthier Without Wheat, and it says, that celiac is just one form of gluten intolerance, and not necessarily the most serious since some other froms can be very damaging to the body as well.

Yes, Gluten Ataxia can effect the brain and/or the nervous system, and DH a form of gluten intolerance can effect the skin. Celiac Disease generally effects the small intestines.

....And it's all gluten related.

IrishHeart Veteran
IrishHeart
Posted

I just read a book Healthier Without Wheat, and it says, that celiac is just one form of gluten intolerance, and not necessarily the most serious since some other froms can be very damaging to the body as well.

I would like to clarify something: Celiac disease is a "form of gluten intolerance" yes, but it has some dire complications not found in NCGI.

And that is not at all what "that book says". The author differentiates these two conditions by discussing them at length.

Page 55

"In order to understand the various forms of gluten intolerance,

we first need to define celiac disease.

This will make it much easier to understand why celiac disease is not the same as gluten intolerance."

" In people with celiac disease, eating gluten leads to a very specific type of damage to the small intestine."

NCGI, which causes many horrid symptoms, does not affect the villi in the small intestine.

and DH ...IS the skin manifestation of celiac disease. Dr. Green states this unequivocally.

Really good scratcher Newbie
Really good scratcher
Posted

Good article! This could explain why so many are mis-diagnosed! I like where it says, Agricultural changes to wheat production may have boosted the protein. Could be a conspiracy theory, but I love conspiracy theories! ;)

ScottR13 Newbie
ScottR13
Posted

That 6% of people with Gluten Sensitivity is way off. It's a whole lot higher. There are also tests available for "Gluten Sensitivity". Wheat IgG, Barley IgG, and Rye IgG. These are Allergy tests unlike the Celiac Panel which only tests for damage caused by Glaidin/Gluten. Even if you are already Gluten Free you will still get a positive. No scope or biopsy needed, just one simple blood test.

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      131,187
    • Most Online (within 30 mins)
      7,748
    Kris46
    Newest Member
    Kris46
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.4k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • Ginger38
      Food Allergies

      By Ginger38 · Posted

      So I recently had allergy testing for IGE antibodies in response to foods. My test results came back positive to corn, white potatoes, egg whites. Tomatoes, almonds and peanuts to name a few.  I have had obvious reactions to a few of these - particularly tomatoes and corn- both GI issues. I don’t really understand all this allergy versus celiac stuff. If the food allergies are mild do I have to avoid these foods entirely? I don’t know what I will eat if I can’t  have corn based gluten free products 
    • Kris2093u4
      Bread choice for a newbie

      By Kris2093u4 · Posted

      Geography makes a difference.  I'm in the West and Trader Joe's gluten-free bread tastes great and is a better price than most gluten-free breads sold elsewhere in my area.  
    • JForman
      7yo struggling!

      By JForman · Posted

      We have four children (7-14 yo), and our 7 year old was diagnosed with NCGS (though all Celiac labs were positive, her scope at 4 years old was negative so docs in the US won't call it celiac). We have started her on a Gluten Free diet after 3 years of major digestive issues and ruling out just about everything under the sun. Our home and kitchen and myself are all gluten-free. But I have not asked my husband/her dad or her other siblings to go completely gluten-free with us. They are at home, but not out of the home. This has led to situations when we are eating out where she has to consistently see others eating things she can't have and she has begun to say "Well, I can't have <fill in the blank>...stupid gluten."  How have you supported your gluten-free kiddos in the mental health space of this journey, especially young ones like her. I know it's hard for me as an adult sometimes to miss out, so I can't imagine being 7 and dealing with it! Any tips or ideas to help with this? 
    • Jane878
      My mo,ther married a bread making when I was 4

      By Jane878 · Posted

      By the time I was 5 I had my first auto0immune disorder, Migraine headaches, with auras to blind me, and vomiting, sensitivity to light and sound. I was 5 years old, and my stepfather would have pizza night, milling his own flour, making thick cheesy gluten pizza, that I would eat and the next day, I would have serious migraines, and my mother & stepfather did nothing about my medical problems. When I was 17 in my first year at college, I was diagnosed with my 2nd known auto-immune disorder, Meniere's disease. I was a elite athlete, a swimmer, and soccer player. And once again my parents didn't think anything of understanding why I had a disorder only older people get. Now after my mother passed from Alzheimer's disease she also suffered with living with gluten. She had a rash for 30 years that nobody could diagnose. She was itchy for 45 years total. My brother had a encapsulated virus explodes in his spleen and when this happened his entire intestines were covered with adhesions, scar tissue and he almost lost his life. He has 5 daughters, and when I finally was diagnosed after being pregnant and my body went into a cytokine storm, I lost my chance to have children, I ended up having Hashimoto's disease, Degenerative Disc disease, and my body started to shut down during my first trimester. I am 6ft tall and got down to 119lbs. My husband and I went to a special immunologist in Terrace, California. They took 17 vials of blood as we flew there for a day and returned home that evening. In 3 weeks, we had the answer, I have Celiac disease. Once this was known, only my father and husband made efforts to change their way of feeding me. At the family cabin, my stepfather & mother were more worried that I would ruin Thanksgiving Dinner. It wasn't until one of my cousins was diagnosed with Celiac disease. They finally looked into getting Gluten Free flour and taking measures to limit "gluten" in meals. He did nothing but ask for me to pay for my own food and wi-fi when I came to the cabin to stay after our house burned down. When he informed my mother, they proceeding to get into a physical fight and she ended up with a black eye. The is just more trauma for me. Sam had no interest in telling the truth about what he wanted. He lied to my mother that he had asked my husband if I could pay for "food" when he asked Geoffrey if I had money to pay for my wi-fi. My mother hates when he spends so much time on the computer so he lied and said I could pay for my own food. I will remind you I weighed 119lbs at this time. (At 6ft) that is a very sick looking person. Neither parent was worried about my weight, they just fought about how cheap my stepfather was. As my mother was diagnosed with Alzheimer's disease in 2014. He had her sign over the will to a trust and added his children. He had no testimonial capacity at the time, so she signed without proper papers. Making this Trust null and void. When I gave my brother my childhood home, my mother stated I would be getting an equal part of inheritance to the house on Race. It currently worth 2.0 million $. I got nothing, and my stepfather has since disowned me b/c of my claim and he knows that my mother would never have left it uneven between my biological brother and myself. She sat me and my husband down, as we lived at the Race Street house and treated and took care of it as our own. My brother took over b/c he was going through a horrific divorce and needed a home so he could get a better custody deal with his soon to be ex-wife who was a Assist DA for Denver. She used the girls against him, and he & I were the primary caregivers. We, Judd and I spent the most time with them pre the divorce. Once Judd moved into the house, he threw all of my mother, grandmother and my family heirlooms out to the Goodwill. Nobody told my mother about this as she was going through cancer treatment and had Alzheimer's disease in her mother and her sister. My stepfather and biological brother took advantage of this matter, as I called a "family council" that my brother just never could make it to at the last moment. All of the furnishing, kitchen ware, everything was in the house my brother just moved into. He had had 2 weddings, I chose to elope b/c my stepfather ruined my brother's first wedding by talking about his relationship with my brother in front of my dad and his entire family, insulting him and having my grandfather leave the ceremony. It was a disaster. My stepfather just plays dumb and blames my father for the slight. I was the only child not to have a wedding. So, my mother and stepfather never had to pay for a thing. My mother had had an agreement with my father he'd pay for college and all medical issues with their kids, myself and Judd. So truly my mother never had to pay for anything big for me in her entire life. I am looking for anyone that has had a similar story, where they grew up in a household that had a baker that regularly milled flour and ate gluten. What happened to you? DId you suffer from different auto-immune diseases b/c of living with a baker using "gluten" Please let me know. I have been looking into legal ways to get my stepfather to give me what my mother had promised, and he erased. Thank you for listening to my story. Jane Donnelly  
    • trents
      Blood results

      By trents · Posted

      Possibly gluten withdrawal. Lot's of info on the internet about it. Somewhat controversial but apparently gluten plugs into the same neuro sensors as opiates do and some people get a similar type withdrawal as they do when quitting opiates. Another issue is that gluten-free facsimile flours are not fortified with vitamins and minerals as is wheat flour (in the U.S. at least) so when the switch is made to gluten-free facsimile foods, especially if a lot of processed gluten-free foods are being used as substitutes, vitamin and mineral deficiencies can result. There is also the possibility that she has picked up a virus or some but that is totally unrelated to going gluten-free.
×
×
  • Create New...