Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Celiac Disease, Gluten Ataxia And Candidiasis / Yeast Overgrowth - A Must Read!
0

11 posts in this topic

http://www.denvernaturopathic.com/news/celiac.html

DNC News: Celiac Disease, Gluten Ataxia and Candidiasis

Subject: Celiac disease, triggered by gluten proteins from wheat in susceptible people, can damage the central nervous system. The cell walls of Candida, the yeast responsible for oral thrush, vaginal infections and intestinal Candidiasis, contain the same protein sequence as wheat gluten and may trigger or stimulate Celiac Disease.

Our understanding of celiac disease has come a long way in the last few years. Several recent studies have linked celiac disease to central nervous system damage which may cause sporadic ataxia. Other studies have identified the particular protein sequence in gluten which causes celiac disease. Other researchers have identified a similar protein in candida yeast and suggest that it may also trigger the same disease. These studies suggest that the typical digestive symptoms we associate with celiac disease are present less than 20% of the time. Having "normal" digestion no longer rules out the disease.

This is a complicated business but I think rather than gloss over it many people deserve and need the details. So please bear with me and skip over the parts that get to thick.

First a bit of background:

Celiac disease is also called coeliac disease or celiac sprue. The Merck Manual defines it as a "chronic intestinal malabsorption disorder caused by intolerance to gluten." [1] The villi of the small intestine atrophy and nutrients are poorly absorbed resulting in steatorrhea (frequent greasy stools) and malnutrition. Sufferers usually get better when gluten containing cereal grains are removed from the diet. Although the syndrome was described earlier, [2] it wasn't until 1950 that the link between dietary cereals and the disease was figured out. [3] During the Second World War when the Germans occupied Holland , children with celiac sprue improved dramatically only to get sick again disease again at the end of the war. During the war, wheat and rye were in short supply in Holland . The researcher who noticed this was able to show that it was the gluten protein in grains which triggered the disease. [4]

Celiac is a genetic disorder and the incidence varies among different populations. Ireland and people of Irish descent have the highest incidence, about 1 person in 300. In Europe and the United States the incidence is much lower, reported at about 1 in 2,500 or less. The longer a population has eaten wheat the lower the incidence. Europeans have cultivated wheat for almost 9,000 years while the Irish have grown it for only about 3,000 years. I suppose we could rename the disease Celtic Sprue rather than celiac sprue. When tested 90% of people with celiac disease are positive for the HLA-B8 antigen in their blood.

The classic problems associated with celiac disease are those of malabsorption and nutritional deficiency. Children with the disease fail to thrive; they are deficient in all of the fat soluble vitamins (A, E, K, and D) and many of the minerals, especially calcium and magnesium. While children are prone to osteomalacia, adults usually develop osteoporosis. This has been the description of celiac disease that medical text books have talked about for decades. Now for what's new.

For the last ten years we have known that celiac disease is associated with hypothyroid disease, specifically Hashimoto's Disease. About 10- 14% of celiac patients are hypothyroid. Celiac patients are about ten times as likely to have thyroid nodules. [5,6,7] Is it the same genetic predisposition making people overly prone to develop autoimmune diseases that causes both conditions? Or is it the chronic bowel inflammation that stimulates these autoimmune reactions? At this point it isn't clear.

Celiac is clearly an autoimmune disease. The gliaden portion of the gluten protein contains a sequence of amino acids that trigger the immune reaction. When they bind on to the intestinal mucosa they act as an antigen and summon killer lymphocytes to attack. The immune system also develops an immune reaction to the muscle lining of the intestine, the endomysium and the enzyme transglutaminase. [8] People with celiac disease make antibodies which attack both the endomysium and the enzyme transglutaminase. Once this autoimmune process has been triggered, damage occurs in other parts of the body and not just the intestine.

Neurological damage occurs with celiac disease. Early on this was thought to be due to nutrient deficiencies caused by malabsorption. Current research shows that the problem is more complex. Celiac disease stimulates the production of antibodies which attack areas besides the intestine including the central nervous system. About 40% of patients who suffer from idiopathic sporadic ataxia have celiac disease which damages their central nervous systems. [9,10,11] The neurological symptoms of celiac disease mimic the symptoms of multiple sclerosis to the degree that celiac must always be ruled out when diagnosing this disease. [12] The neurological conditions caused by celiac disease are now called gluten ataxia and cause damage to the cerebellum, the posterior columns of the spinal cord, and the peripheral nerves. [13]

The studies on gluten ataxia have revealed a significant statistic. In patients who had clearly measurable antibodies that are diagnostic of celiac disease and were suffering from gluten ataxia, only 13% had any gastrointestinal complaints. In other words, the hallmark symptoms of poor digestion we associate with celiac disease and use to diagnose the condition may be absent in 87% of patients with gluten related problems! [14] This suggests that celiac may be way under diagnosed.

Now we come to what to me is the most interesting of the recent research regarding celiac. It seems fitting that the research again comes from Holland , where celiac disease was first linked to diet. Dr. Nieuwenhuizen, from the research group TNO Nutrition and Food Research, published a paper in the June, 2003, Lancet. He links celiac disease with Candida albicans. Dr. Nieuwenhuizen, knowing the actual sequence of proteins which trigger celiac disease from the published work of other scientists, had searched the databases available to him through TNO to see if the same sequence existed in other places. It turns out the identical sequence of proteins occur in the cell walls of Candida albicans. [15]

These Candida gluten-like proteins turn out to be the yeast's "hypha-specific surface protein" nicknamed Hwp1. This is the yeast's version of Velcro and allows it to attach and hang onto the endomysium in the wall of the intestine. It is also targeted by transglutaminase, the enzyme which acts on the gluten protein and serves as a target for immune antibodies. Candida species which don't have this Hwp1 protein can't attach themselves to the digestive tract. [16]

If Candida can trigger the same chemical and immunological reactions as wheat gluten do we can imagine a number of interesting implications.

First, in people with celiac disease, symptoms usually get better rapidly when they eliminate gluten from their diet. This isn't always the case. Even without gluten some people continue to have symptoms. They may have intestinal Candidiasis. The Candida in their gut may be acting like gluten and continues triggering symptoms.

Second, an acute Candida infection may trigger the onset of celiac disease. Even if the Candida is treated and eliminated, the person could be left with a permanent sensitivity to wheat gluten. Candida infections occur frequently with antibiotic usage. In people genetically susceptible to celiac, extra caution should be exercised when using antibiotics to prevent Candida overgrowth.

Third, if wheat can cause neurological damage as in gluten ataxia, it is reasonable to assume that Candida could also do so by the same process. Reports of Candida infections causing neurological symptoms are not uncommon; now we have a possible explanation.

Fourth, if only a small portion of the people with gluten ataxia have gastrointestinal symptoms despite their severe damage elsewhere in their bodies, it is reasonable to assume that Candida could stimulate significant problems while producing slight or no digestive symptoms.

So what does all this mean? Here's my bottom line:

Celiac disease may be grossly under diagnosed. It should be ruled out in any chronic digestive condition even if the symptoms don't fit the classic picture. Celiac disease should also be ruled out in osteoporosis and in neurological problems, especially MS. Celiac disease should also be ruled out in Hashimoto's Disease and other thyroid abnormalities. Whenever Celiac disease is diagnosed, Candida infections should be tested for and treated aggressively. People of Irish descent are far more likely to get celiac disease than others and should be extra cautious to avoid Candida infections and treat them aggressively if they occur.

References:

1. Merck Manual, Seventeenth Edition

2. Thaysen T, Non-Tropical Sprue. Copenhqagen, Levin and Munsgaard. 1932.

3. Dicke, W. Coeliac Disease: Investigation of harmful effects of certain types of cereal on patients with celiac disease. Doctoral Thesis, University of Utrecht . Netherlands , 1950.

4. Van de Kramer, Weijers, Dicke. Coeliac Disease. IV. An investigation into the injurious constituents of wheat in connection with their action on pateinets with celiac disease. Acta Paediat. 42.223, 1953

5. Counsell et al. Coeliac disease and autoimmune thyroid disease. Gut 1994;35: 844-846

6. Collin et al. Autoimmune thyroid disorders and coeliac disease. European Journal of Endocrinology 1994;130:137-140

7. Freeman H. Deliac associated autoimmune thyroid disease: A study of 16 patients with overt hypothyroidism. 1995; July/Aug: 9(5): 242-246

8. Nat Med. 1997 Jul;3(7):797- Identification of tissue transglutaminase as the autoantigen of celiac disease.

Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, Schuppan D.

9. Brain. 2001 May;124(Pt 5):1013-9. Sporadic cerebellar ataxia associated with gluten sensitivity.

Burk K, Bosch S, Muller CA, Melms A, Zuhlke C, Stern M, Besenthal I, Skalej M, Ruck P, Ferber S, Klockgether T, Dichgans J

10. Neurology. 2002 Apr 23;58(8):1221-6The humoral response in the pathogenesis of gluten ataxia. Hadjivassiliou M, Boscolo S, Davies-Jones GA, Grunewald RA, Not T, Sanders DS, Simpson JE, Tongiorgi E, Williamson CA, Woodroofe NM.

11. J Neurol Neurosurg Psychiatry. 2003 Sep;74(9):1221-4

Dietary treatment of gluten ataxia. Hadjivassiliou M, Davies-Jones GA, Sanders DS, Grunewald RA.

12. Neurol Sci. 2001 Nov;22 Suppl 2:S117-22

Neurological manifestations of gastrointestinal disorders, with particular reference to the differential diagnosis of multiple sclerosis. Ghezzi A, Zaffaroni M.

13. Lancet. 1998 Nov 14;352(9140):1582-5 Clinical, radiological, neurophysiological, and neuropathological characteristics of gluten ataxia. Hadjivassiliou M, Grunewald RA, Chattopadhyay AK, Davies-Jones GA, Gibson A, Jarratt JA, Kandler RH, Lobo A, Powell T, Smith CM.

14. J Neurol Neurosurg Psychiatry. 2003 Sep;74(9):1221-4 Dietary treatment of gluten ataxia. Hadjivassiliou M, Davies-Jones GA, Sanders DS, Grunewald RA.

15. Lancet. 2003 Jun 21;361(9375):2152-4. Is Candida albicans a trigger in the onset of coeliac disease?

Nieuwenhuizen WF, Pieters RH, Knippels LM, Jansen MC, Koppelman SJ.

16. Science. 1999 Mar 5;283(5407):1535-8. Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1. Staab JF, Bradway SD, Fidel PL, Sundstrom P.

.....................................................

Hey! You're getting these newsletters either because you've signed up to be on the list or because we took the liberty of putting you on. If you want your name removed simply leave a message at the office (303-337-4884) or go to the website: denvernaturopathic.com and unsubscribe, or reply with the message "REMOVE" in the subject line. If on the other hand you want to be added to the mailing list follow the prior instructions but subscribe. We are finally trying to keep up with our website and are posting most of these newsletters in our 'archive' section. Frequently we also post abstracts of references quoted for the intellectually curious.

1

Share this post


Link to post
Share on other sites


Ads by Google:

Thank you for posting this. I am someone who had the neuro effects since childhood but didn't have severe gut reactions until my mid 30's, after my children were born. I hope the news spreads fast. If my neurologist had know this it would have saved me years of pain. Even with brain lesions he said it was 'all in my head and I wanted to be sick'. This even with those lesions and a complete loss of reflexes in my legs and a totally flat result with the electromylograms (a fun test where they stick needles in your muscles and then measure the response to electrical current).

1

Share this post


Link to post
Share on other sites

Can an upper endoscopy with biopsy also find signs of a Candida infection?

0

Share this post


Link to post
Share on other sites

Can an upper endoscopy with biopsy also find signs of a Candida infection?

I would suggest that you post this in a new topic. I don't know the answer but others might.

0

Share this post


Link to post
Share on other sites

wow, very interesting article ... thanks for sharing!

0

Share this post


Link to post
Share on other sites




Wow, this is very interesting. I need to read it again sans kiddos running around.

I have had reccurent yeast problems. I had thrush really bad each time we would start nursing. My second son, who has celiac, we has VERY resistant yeast. It took us FOREVER to get over it, months. When I was pregnant with my 3rd child I got reccurent vaginal yeast infections and then we got thrush too, although we went right on diflucan and kicked it pretty easily.

I still wonder if myself and my son with Celiac have yeast overgrowth in the stomach. How would one find that out??

We are also very Irish, intersting.....I am also sure my neurologist would have missed this whole connection, had it not been for myself advocating. He did make the assumption after I asked for the right tests though. He said this is a new thing they are finding out with Celiac and gluten sensitivity.

0

Share this post


Link to post
Share on other sites

I've been suffering from yeast infections (the female kind) since I was 13. There have been times when I've had chronic yeast infections for months. I would use all these creams, etc, but they kept coming back. I've tried eating less sugar. But I'm really suspicious if this is a symptom of celiac disease, which I was just diagnosed with last month. There are times for months when I have no problems and then suddenly, they start again. There seems to be no clear pattern, although I notice that sometimes I get them just before I get my period.

Interesting about the Irish connection. My mom's side of the family is Scots-Irish heritage.

0

Share this post


Link to post
Share on other sites

Well this gluten topic just keeps getting more interesting. I don't know whether to scratch my watch or wind my butt at this point. I come from a heavy Irish background. Born with green eyes and red hair. And I have had the same yeast infection that won't go away. Yeah, I've had that since February when all these other symptoms started. Another thing I never considered, like the rash on the elbow and the dry eye and millions of other things (ok, that may be pushing it) but geez Louise! it's just WHEAT! it's not like it's nicotine or heroin, I mean it seems so pure, wheat does, it just doesn't seem it could wreak all this havoc! I'm not saying it doesn't, but for pity sakes!

0

Share this post


Link to post
Share on other sites

I came across this thread while googling "candida and celiac link." I have a question:

If I was extremely gluten-light before my blood tests, but have been dx w/systemic candida, is there a chance that could make my blood tests positive?

In other words, since the candida seems to cause the same reaction, would it show up on the blood test (I do believe I have celiac, as well)?

Please ask if this question isn't clear...thanks so much!

0

Share this post


Link to post
Share on other sites

The tests are for antibodies (or that type of immune reaction) to the grain proteins, and candida is a fungus, so I don't think having one skews the other tests. I suspect that there is a lot of stuff we don't really know about this yet, on they layperson's level, but the susceptability to yeast infections is also a sign that the whole metabolic system is "off," and sugars and carbs are not being used effectively - and that's a side effect of thyroid disease, caused by the celiac....

0

Share this post


Link to post
Share on other sites

"The cell walls of Candida, the yeast responsible for oral thrush, vaginal infections and intestinal Candidiasis, contain the same protein sequence as wheat gluten and may trigger or stimulate Celiac Disease."

I know it's a stretch, but in light of this quote, it could be possible, right (for a positive test)?

Could this explain why some people test positive after being gluten-free for awhile, and some don't?

And, yes, I have hypothyroid as well as Lyme. So many things overlap!

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      103,366
    • Total Posts
      917,513
  • Topics

  • Posts

    • What Are Your Brands & Flavors Of Gluten Free Ice Cream ?
      I don't worry about the same facility, but I check if it is on the same lines. I think it is usually a good idea to find out if things are made on shared lines. And if they are made on the same line as gluten-containing products how good is the cleaning in between? Chocolate is a good example of this. For example, I contacted a company whose chocolate I used to eat before being diagnosed and they outright told me they are not good about cleaning on shared lines and it is not safe for allergies or celiac. I have had this response from other companies as well (especially when it comes to chocolate sadly). I think this is why Godiva is not safe. Its just a good idea to check.
    • TRUSTING OTHERS about GLUTEN! how do you know if someone has used gluten free flour?
      Wow you all have more balls than I do. I've been gluten free since 2007 and I'm still afraid of offending people. It gives me lots of troubles, really. I'm more like rockstarkate I guess...the "people pleasing" aspect.  I love how you all just have the flat out rule I Will Not Eat It Unless I or a Celiac Made it. (Or a trusted family member).  I still simper and grovel and cringe and apologetically turn things away.  People still put dishes in my face and say "This should be gluten free..."  and I have to awkwardly not eat it and then seem rude.  I've done the whole...checking the bottles thing too.  I do try to dart out of things more though now. I volunteered in other countries in recent years and I felt as vulnerable as all heck, having to rely on them to make food, as well as definitely feeling like I offended people who didn't get it at all. I was feeling brave when I signed up for those but after the second time I was like okay, the fear/anxiety/stress about the food is too much. I managed to dodge out of getting sick, and for the most part people humored me...but it was pretty difficult because I don't like offending people, especially other cultures, with them trying to be nice and make food for me...pretty sure I did offend people as well as annoy many others.  Anyway...no OP, you are not alone. For sure I have trust issues eating other people's food. They say they know but I do truly doubt they are as strict as I would be.   A few times I will still brave eating something...like some little mozzarella balls with vinegar...though, I did still look at the labels.  Someone had to give me a persuasive speech and show me all ingredients (just salt and pepper) after making me chicken wings once. I do tell people, basically, NOT to make me stuff. But they still do.  Another time a friend had worked really hard and was having a terrible time and offered me a burger patty when I arrived, assuring me it was gluten free. I knew I hadn't been there to watch whether she used the "bun spatula" on it or not...but I just didn't feel like giving her a fight about it since she was having a rough time and hosts like to feel they are feeding guests, blah blah. So I ate it. And got glutened. And wailed and gnashed my teeth haha. Lesson learned.  I need to stick to my guns more. I just always feel like I'm being too "difficult" as it is. But...sigh.  It is refreshing for me to read these empowered no BS responses though. You all remind me of where I'm coming from, and not that I'm just being some kind of high maintenance, rude, crazy person. You'd think after, what, nine years now, I wouldn't still be bothered by it...
    • Mashed potato soup during healing
      I was on pretty much a liquid diet for 8 months waiting for my nausea to go away completely. I mostly had mashed potato soup, 1/2 fat ice cream (mostly whey, not milk), chocolate drink (no added milk) and gummy vitamins. The soup tasted yummy and I'm still alive so I figured I'd share it for people not feeling well in the beginning. I've been noticing people with alot of trouble keeping food down in recent posts. I couldn't have milk or eggs, but the cheese in the recipe didn't bother me at all. Notice the lack of spices. Makes it easy on the stomach.   Mashed potato soup: Boiled yukon gold potatoes (5lb bag) 1 package cauliflower, steamed 4-6 slices of Land O'Lakes white American cheese 4 tablespoons butter salt 16 cups homemade chicken broth, salted   Chop steamed cauliflower into teensy bits (pureed is better). Put in mixer with butter, cheese and a potato or two. Blend while slowly adding potatoes. Keep whipping for a few minutes to insure the cauliflower and potatoes are not lumpy at all. Salt to taste.   Combine 1/2 cup mashed potatoes to 1 cup salted chicken broth. Mix with spoon until mashed potatoes have completely dissolved. Enjoy. Individual servings can be frozen.   Homemade chicken broth: makes 8 - 10 cups of broth   1 organic chicken (regular chickens are too big) 1 stalk celery 1 carrot 1 large bay leaf 1/2 package fresh thyme from the  herb section of the vegetables area   Put all ingredients in pressure cooker along with 1.5 liters water. Bring to pressure. Cook for 35 minutes. Separate broth from solids. Separate broth from fat. Add ridiculous quantities of salt until it tastes like soup. Sorry I use a salt grinder so I don't have precise salt quantities.    
    • I have kidney stones...spent last night at the ER
      Hey ArtG, I saw the urologist today...unfortunately for me they can still see my stones on an xray.  Sigh.  The largest is 3x6 in my right kidney.  He does not believe I can pass this one on my own.   All of my bloodwork came back fine.  Nothing alarming in the urinalysis either. His recommendations...keep drinking tons of water.  I had 4.2 liters of urine output when I tested.  Add in a fish oil supplement.  Decrease sodium intake.  Limit meat to 10 ounces per day.  Increase dietary calcium.   Work at lowering oxalate consumption...my urinary oxalate was 45.  They want it between 20 and 40.  But he gets people that are over 100 so mine is not all that high. 3 options...1. watch and wait.  Recheck in a few months to see if there is stone growth.  2. Shock wave lithotripsy.  3. Let it come out when it decides to and see what happens. I just don't know.  I hate the idea of being put under as they would do for the shock wave thing.  I've had too many surgeries already.  It scares me to be honest.  I also don't want to deal with another episode.   I don't know what I'll do.  We've got a vacation planned at the end of the month and I just want to go and enjoy that.  Not worry about kidney stones. I'm sorry to hear about your upcoming surgery...it really is always something!
    • celiac disease is psychosomatic
      I know what food products are. Probiotics was a recent example I saw on the news about things labeled gluten free that were not gluten free. So, supplement labels in addition to food labels.
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

    • Larry Gessner  »  cyclinglady

      Hi There, I don't know if there is a place for videos in the forum. I just watched "The Truth About Gluten" I think it is a good video. I would like to share it somewhere but don't know where it should go. Any help would be greatly appreciated.
      Here is the link if you have never watched it.
      https://youtu.be/IU6jVEwpjnE Thank You,
      Larry
      · 2 replies
    • ChiaChick  »  Peaceflower

      Hi Peaceflower, Just wanted to say thank you for the chat.
      · 0 replies
    • ukuleleerika

      Hello! I am new to this Celiac website... Is there anyone out there with Celiac AND extensive food allergies? My allergies include shellfish, dairy, eggs, cantaloupe, kiwi, mango, nuts, oranges, red dye, and more I can't think of. I went to the allergist about a year ago to see why I wasn't feeling well, and once everything was eliminated, I still didn't feel well. We did more testing to find out I had celiac as well as allergies to cattle as well as rye grass (I live on a farm basically). This was back in January 2016. I recently had my endoscopy with the gastroenterologist a week ago. I have no idea what to do or what to eat... So fish and potatoes for me!
      · 2 replies
  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      60,513
    • Most Online
      1,763

    Newest Member
    ajrosales
    Joined