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Test Results Help Please

veryami1

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veryami1 Apprentice
veryami1
Posted

Hi,

 

I just returned from an appointment with my GI. She said I am negative for celiac, however, the copy of the test results I received said "supports a diagnosis of celiac." I am obviously confused. I went back to ask her why she said it was negative, and she didn't have time for me. Suffice to say, I won't be going back. But I do have these results and I'd like your opinion on how to interpret them.

 

Deamidated Gliadin Peptide Antibody - IgG - 43.0 EU

Deamidated Giagin Peptide Antibody IgA - 9.3 EU

Anti-hunman tissue transglutaminase igA - 75.0 EU

Anti-endomysial igA IFA - positive

total serum iGA by Nephelometry, total igA - 129

 

One ellele HLA DqA1*05 of Dq2.5 detected, HLA DQB81*02 not detected.

Celiac risk haplotype not detected

 

I suspect because I do not test positive for the gene, she said I was negative for celiac? Any opinions? Would really appreciate any help!

 

For some reference, I blood test positive for a wheat allergy and I've been avoiding gluten for almost three weeks because I suspet celiac.

 

thank you!

 

Ami

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GottaSki Mentor
GottaSki
Posted

Hi,

 

I just returned from an appointment with my GI. She said I am negative for celiac, however, the copy of the test results I received said "supports a diagnosis of celiac." I am obviously confused. I went back to ask her why she said it was negative, and she didn't have time for me. Suffice to say, I won't be going back. But I do have these results and I'd like your opinion on how to interpret them.

 

Deamidated Gliadin Peptide Antibody - IgG - 43.0 EU

Deamidated Giagin Peptide Antibody IgA - 9.3 EU

Anti-hunman tissue transglutaminase igA - 75.0 EU

Anti-endomysial igA IFA - positive

total serum iGA by Nephelometry, total igA - 129

 

One ellele HLA DqA1*05 of Dq2.5 detected, HLA DQB81*02 not detected.

Celiac risk haplotype not detected

 

I suspect because I do not test positive for the gene, she said I was negative for celiac? Any opinions? Would really appreciate any help!

 

For some reference, I blood test positive for a wheat allergy and I've been avoiding gluten for almost three weeks because I suspet celiac.

 

thank you!

 

Ami

 

Welcome Ami!

 

Looks like your doctor is wrong and you do have Celiac Disease in addition to your wheat allergy - Make sure your primary doc gets copies of all these tests -- unless you want to proceed with an endoscopy, there is no need for a celiac specialist.  If you decide to proceed with an endo -- try to find another GI that has training/experience with Celiac Disease.

 

Do you have the ranges for these tests -- they certainly look like they support a diagnosis of Celiac Disease - especially the positive Anti-Endomysial IgA -- also known as EMA-IgA.

 

Were you already gluten free for a time before these antibody tests were run?

 

Let us know the ranges if you have them.

veryami1 Apprentice
veryami1
Posted
  • Author

Hi Lisa,

Thanks for the quick reply. These are the ranges listed on the paperwork, in parenthesis.

 

Deamidated Gliadin Peptide Antibody - IgG - 43.0 EU  (<4.9 EU)

Deamidated Giagin Peptide Antibody IgA - 9.3 EU  (<6.1 EU)

Anti-hunman tissue transglutaminase igA - 75.0 EU (<10.3)

Anti-endomysial igA IFA - positive  (range, negative)

total serum iGA by Nephelometry, total igA - 129   (<3 years, 8-220, 3-13 years 41-395, >13, 44-441)

 

I don't know how to interpret any of the above!

 

I've been wheat/gluten free for 3 weeks, on Saturday. At the time of the above blood test, I was about 2 weeks free.

 

What leads you to quickly say that yes, I am celiac positive?

 

Thanks for any help! I found another doctor for a follow up in two weeks, will stay gluten-free regardless of all of this! My allergies seem to be clearing although my stomach issues are roughly the same since starting gluten-free.

 

Ami

cmc811 Apprentice
cmc811
Posted

Every one of your tests was positive. Get a new GI or like Lisa said make sure your PCP has these results.

GottaSki Mentor
GottaSki
Posted

Every one of these tests is strong positive, which is what it looked like - but I do like to see ranges because ranges vary between labs.

 

Glad you'll be seeing another doctor soon.

 

It takes time for symptoms to improve gluten-free.  Sometimes it is days, weeks, months and sadly even years....but things do improve.  Healing happens.

 

The tTG-IgA and EMA-IgA both indicate there is damage within your small intestine caused by an autoimmune reaction that your body has to gluten.  This is not an allergy, but a person can be both celiac and allergic to wheat, barley or rye.

 

The  Deamidated Gliadin Peptide (DGP-IgA and IgG) are tests that measure the antibodies your body is producing to one of the peptides in the protein of Gluten - called Gliadin.

 

Hope that make sense.  

 

If there is a chance that you will be having an endoscopic biopsy you will need to continue to consume gluten each day -- it can be very tough to add it back in, so talk to the new doctor about your options.

 

Here is a great thread for those newly diagnosed and those new to living gluten-free:

 

https://www.celiac.com/forums/topic/91878-newbie-info-101/

 

Hang in there :)

veryami1 Apprentice
veryami1
Posted
  • Author

Thank you all SO much! What do the allelle results mean?

 

Do you think that she interpreted the results as negative simply because I did not test positive for both genes? How can she be so stupid, to put it not so mildly?

 

With these results, is there ANY WAY I can not have celiacs, not taking into account possible testing errors or such?

 

Looking forward to getting to know everyone here more, since I think I'll be staying around :)

 

Ami

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