Test Results Help Please

[veryami1]

Hi,

 

I just returned from an appointment with my GI. She said I am negative for celiac, however, the copy of the test results I received said "supports a diagnosis of celiac." I am obviously confused. I went back to ask her why she said it was negative, and she didn't have time for me. Suffice to say, I won't be going back. But I do have these results and I'd like your opinion on how to interpret them.

 

Deamidated Gliadin Peptide Antibody - IgG - 43.0 EU

Deamidated Giagin Peptide Antibody IgA - 9.3 EU

Anti-hunman tissue transglutaminase igA - 75.0 EU

Anti-endomysial igA IFA - positive

total serum iGA by Nephelometry, total igA - 129

 

One ellele HLA DqA1*05 of Dq2.5 detected, HLA DQB81*02 not detected.

Celiac risk haplotype not detected

 

I suspect because I do not test positive for the gene, she said I was negative for celiac? Any opinions? Would really appreciate any help!

 

For some reference, I blood test positive for a wheat allergy and I've been avoiding gluten for almost three weeks because I suspet celiac.

 

thank you!

 

Ami

[GottaSki]

Hi,

 

I just returned from an appointment with my GI. She said I am negative for celiac, however, the copy of the test results I received said "supports a diagnosis of celiac." I am obviously confused. I went back to ask her why she said it was negative, and she didn't have time for me. Suffice to say, I won't be going back. But I do have these results and I'd like your opinion on how to interpret them.

 

Deamidated Gliadin Peptide Antibody - IgG - 43.0 EU

Deamidated Giagin Peptide Antibody IgA - 9.3 EU

Anti-hunman tissue transglutaminase igA - 75.0 EU

Anti-endomysial igA IFA - positive

total serum iGA by Nephelometry, total igA - 129

 

One ellele HLA DqA1*05 of Dq2.5 detected, HLA DQB81*02 not detected.

Celiac risk haplotype not detected

 

I suspect because I do not test positive for the gene, she said I was negative for celiac? Any opinions? Would really appreciate any help!

 

For some reference, I blood test positive for a wheat allergy and I've been avoiding gluten for almost three weeks because I suspet celiac.

 

thank you!

 

Ami

 

Welcome Ami!

 

Looks like your doctor is wrong and you do have Celiac Disease in addition to your wheat allergy - Make sure your primary doc gets copies of all these tests -- unless you want to proceed with an endoscopy, there is no need for a celiac specialist.  If you decide to proceed with an endo -- try to find another GI that has training/experience with Celiac Disease.

 

Do you have the ranges for these tests -- they certainly look like they support a diagnosis of Celiac Disease - especially the positive Anti-Endomysial IgA -- also known as EMA-IgA.

 

Were you already gluten free for a time before these antibody tests were run?

 

Let us know the ranges if you have them.

[veryami1]

Hi Lisa,

Thanks for the quick reply. These are the ranges listed on the paperwork, in parenthesis.

 

Deamidated Gliadin Peptide Antibody - IgG - 43.0 EU  (<4.9 EU)

Deamidated Giagin Peptide Antibody IgA - 9.3 EU  (<6.1 EU)

Anti-hunman tissue transglutaminase igA - 75.0 EU (<10.3)

Anti-endomysial igA IFA - positive  (range, negative)

total serum iGA by Nephelometry, total igA - 129   (<3 years, 8-220, 3-13 years 41-395, >13, 44-441)

 

I don't know how to interpret any of the above!

 

I've been wheat/gluten free for 3 weeks, on Saturday. At the time of the above blood test, I was about 2 weeks free.

 

What leads you to quickly say that yes, I am celiac positive?

 

Thanks for any help! I found another doctor for a follow up in two weeks, will stay gluten-free regardless of all of this! My allergies seem to be clearing although my stomach issues are roughly the same since starting gluten-free.

 

Ami

[cmc811]

Every one of your tests was positive. Get a new GI or like Lisa said make sure your PCP has these results.

[GottaSki]

Every one of these tests is strong positive, which is what it looked like - but I do like to see ranges because ranges vary between labs.

 

Glad you'll be seeing another doctor soon.

 

It takes time for symptoms to improve gluten-free.  Sometimes it is days, weeks, months and sadly even years....but things do improve.  Healing happens.

 

The tTG-IgA and EMA-IgA both indicate there is damage within your small intestine caused by an autoimmune reaction that your body has to gluten.  This is not an allergy, but a person can be both celiac and allergic to wheat, barley or rye.

 

The  Deamidated Gliadin Peptide (DGP-IgA and IgG) are tests that measure the antibodies your body is producing to one of the peptides in the protein of Gluten - called Gliadin.

 

Hope that make sense.  

 

If there is a chance that you will be having an endoscopic biopsy you will need to continue to consume gluten each day -- it can be very tough to add it back in, so talk to the new doctor about your options.

 

Here is a great thread for those newly diagnosed and those new to living gluten-free:

 

https://www.celiac.com/forums/topic/91878-newbie-info-101/

 

Hang in there

[veryami1]

Thank you all SO much! What do the allelle results mean?

 

Do you think that she interpreted the results as negative simply because I did not test positive for both genes? How can she be so stupid, to put it not so mildly?

 

With these results, is there ANY WAY I can not have celiacs, not taking into account possible testing errors or such?

 

Looking forward to getting to know everyone here more, since I think I'll be staying around

 

Ami