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So Confused About Tests!


Quaylern

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Quaylern Rookie

I took my 6 year old daughter in to a pediatric gastroenterologist after having a positive saliva test. I checked her chart this morning and it shows her TtG was 10. Not much more explanation of the result so I emailed the doctor for an explanation. Her nurse wrote back and said 0-19 are in the normal range so 10 is normal. But when I looked at the mayo clinic's celiac testing chart it said 0-4 negative, 4-10 should be further tested based on EMA or AGA IgA results and anything more than 10 should go to biopsy. I asked if they ran either of those and they only ran total IgA and TtG. I emailed back asking for further explanation since the info from the mayo clinic is different. I just want to feel that they are interpreting the results correctly.

Here is the info from her saliva test:

Cyrex lava Array 1

Secretory IgA 5.02

Gliadin IgA+IgM > 3.40

Transglutaminase IgA+IgM >3.10

The doctor said these are some of the highest test results that he's seen. He called the lab to verify that they were correct. He said it's most likely autoimmune and to follow up with a gastroenterologist.

I am so confused. Any ideas on how to interperate these results would be hugely helpful! I don't know if we just assume all is fine now and keep an eye on her?


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StephanieL Enthusiast

Different labs use different test/testing levels. If your Dr. said 1-19 was the normal range, then 10 would be within that.

 

The saliva test, who ordered that? 

Quaylern Rookie

The saliva test was ordered by a functional medicine practitioner that specializes in gluten intolerance and celiac.

StephanieL Enthusiast

There isn't a test for any sort of gluten intolerance that is considered accurate for diagnostic purposes.  

 

Based on the other testing, the tTG was well within the limits for the lab your Dr. used. 

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    • par18
      Thanks for the reply. 
    • Scott Adams
      What you’re describing is actually very common, and unfortunately the timing of the biopsy likely explains the confusion. Yes, it is absolutely possible for the small intestine to heal enough in three months on a strict gluten-free diet to produce a normal or near-normal biopsy, especially when damage was mild to begin with. In contrast, celiac antibodies can stay elevated for many months or even years after gluten removal, so persistently high antibody levels alongside the celiac genes and clear nutrient deficiencies strongly point to celiac disease, even if you don’t feel symptoms. Many people with celiac are asymptomatic but still develop iron and vitamin deficiencies and silent intestinal damage. The lack of immediate symptoms makes it harder emotionally, but it doesn’t mean gluten isn’t harming you. Most specialists would consider this a case of celiac disease with a false-negative biopsy due to early healing rather than “something else,” and staying consistently gluten-free is what protects you long-term—even when your body doesn’t protest right away.
    • Scott Adams
      Yes, I meant if you had celiac disease but went gluten-free before screening, your results would end up false-negative. As @trents mentioned, this can also happen when a total IGA test isn't done.
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    • Churley
      Have you tried Pure Encapsulations supplements? This is a brand my doctor recommends for me. I have no issues with this brand.
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