Gluten Igg Antibodies If Not Celiac?

[heliosue]

Hi folks, checking in again with a new question. After some heavy duty persuasion, my doctor (Internist) ordered a Total IGA serum blood test for me. The result was 132, which is definitely in the normal range.

So..the only positive result was my TTG, IGG number, which was 10 (reference range >6 is high).  My question is this: Where would I get the IGG antibodies if I was not Celiac. Would they also show up if I am Non-Celiac Gluten Intolerent. I'm still trying to make some sense of this diagnosis!  Thanks.

[BlessedMommy]

If you had a positive ttG test, then you most likely are celiac. NCGI does not produce antibodies.

Has the doctor referred you out for an endoscopy yet?

[nvsmom]

I agree.  The positive tTG IgG means that your body is attacking the endomysial layer of your intestines.  That will never happen with NCGI (NCGS), in fact that is the defining difference between the two.

 

Take a look at this paper: Open Original Shared Link The (SN) sensitivity of the tTG IgG test is low at 40% (meaning it misses over half of all celiacs), but the specificity (SP) is 95% which means that 95% of positive test results are caused by celiac disease and false positive happen only 5% of the time.

 

Those false positive in the tTG IgA can be caused by thyroiditis, diabetes (T1), colitis, crohn;s, chronic liver disease, or a serious infection. It won't be positive for no reason, and I believe it is the same for the tTG IgG.  These are usually weak positives too (like a 5) but you are almost 50% above the high upper limit - that is quite positive. Chances are, you have celiac disease, especially if you have symptoms.

 

Best wishes.