Test Results, advice appreciated

[sgf743]

Hi, 

I'm hoping I can get a bit of guidance here until I get an appointment with a second doctor... I just had a second celiac panel and am confused about my results, as well as my doctor's interpretation. Any help or advice is appreciated, as I am totally new to learning about celiac disease. 

First testing (Oct 2016) 

Gliadin IGA 2.4  (normal range <14.9)

Gliadin IGG 19.2 (normal <14.9)......HIGH

ttG IGA  .5 (normal <14.9)

ttG IGG .8 (normal <14.9)

 

Second testing (May 2017)

Gliadin IGA 1.8 (normal <14.9)

Gliadin IGG 23.7 (normal <14.9).....HIGH (even higher than first test)

ttG IGA .5 (normal <14.9)

ttG IGG .8 (normal <14.9)

 

 

I also tested positive for ANA (autoimmunity), negative rheumatoid arthritis, have an enlarged thyroid (but no hashimotos).  I also experience diarrhea, gas, bloating, acid reflux/heartburn, extreme fatigue all the time, sensitivity to dairy. inflammation markers normal, normal HIDA scan, normal CT scan of abdomen. 

 

Doctor says "unlikely that you have celiac or gluten issues, i believe this positive igg is some sort of cross reaction"  but is unable to explain any further.....trying to research leads me to mixed answers. 

Any advice? 

 

Thank you so much .

 

[tessa25]

A high on any one celiac test should result in a gastroenterologist doing an endoscopy to see if there is a positive diagnosis of celiac. There are members here that were only high on one test.

 

 

[Feeneyja]

Just so you know, the test for gliadin IgG and IgA are probably deamidated gliadin.  This is important because those are considered very accurate celiac tests.  By your IgG levels, it would indicate celiac disease, but would need to be confirmed by biopsy.  See below...

This is from Mayo Clinic:

Positive test results for deamidated gliadin antibodies, IgA or IgG, are consistent with the diagnosis of celiac disease.

 

Negative results indicate a decreased likelihood of celiac disease.

 

Decreased levels of deamidated gliadin antibodies, IgA or IgG, following treatment with a gluten-free diet are consistent with adherence to the diet. Persistence of high levels of antibodies following dietary treatment suggest poor adherence to the diet or the presence of refractory disease. 

Cautions 

Measurements of deamidated gliadin antibodies should not be relied upon exclusively to establish or rule out the diagnosis of celiac disease.

[sgf743]

8 minutes ago, tessa25 said:

A high on any one celiac test should result in a gastroenterologist doing an endoscopy to see if there is a positive diagnosis of celiac. There are members here that were only high on one test.

 

 

Thank you for this information!

[sgf743]

2 minutes ago, Feeneyja said:

Just so you know, the test for gliadin IgG and IgA are probably deamidated gliadin.  This is important because those are considered very accurate celiac tests.  By your IgG levels, it would indicate celiac disease, but would need to be confirmed by biopsy.  See below...

This is from Mayo Clinic:

Positive test results for deamidated gliadin antibodies, IgA or IgG, are consistent with the diagnosis of celiac disease.

 

Negative results indicate a decreased likelihood of celiac disease.

 

Decreased levels of deamidated gliadin antibodies, IgA or IgG, following treatment with a gluten-free diet are consistent with adherence to the diet. Persistence of high levels of antibodies following dietary treatment suggest poor adherence to the diet or the presence of refractory disease. 

Cautions 

Measurements of deamidated gliadin antibodies should not be relied upon exclusively to establish or rule out the diagnosis of celiac disease.

Thank you for this info! 

[ironictruth]

Deamidated Gliadin (assuming this was what your test was...does it happen to say Gliadin Lite II anywhere?) can show up positive for diseases other than celiac. It is a newer test, roughly 10 years old (used under that amount of time in the states) and the research is ongoing. It replaces the OLDER gliadin tests which MOST labs no longer use, but SOME still do. Trouble is, it has such a similar name to the older tests, most docs do not even know that it is a newer version and the old tests got such a bad rap, they disregard them all together.  All of the previous research on Deamidated Gliadin is that it is highly specific to celiac disease. Newer research is showing that this is not necessarily the case.

 

That being said, given the mixed research on the test and the fact that members here have had celiac disease damage on biopsy with only DGP being positive, I think it is irresponsible to not move forward with a biopsy and genetic testing. DGP shows up positive in young children before TTG does and it is possible it does the same in adults. More research needs to be done on that. In fact, one of the recent studies on false positive DGP actually points out one of the limitations of the study was the inability to track the participants for development of celiac disease.

 

STAY ON GLUTEN. Going off of it and on it again may effect your biopsy results as there is no "set" amount of time for a gluten challenge to cause the kind of damage in significant amounts to be picked up on biopsy.

 

You should also have an EMA test done. Rare that it would be positive with a negative TTG, but still possible as  some on these boards could tell you.

 

"cross reaction" to what? DGP can be found positive in autoimmune diseases, but I am unaware of what "cross reaction" means. Sounds like bulls$#& to me.

 

You might need to shop for another doc while you continue eating delicious donuts (chocolate covered white cream) awaiting your further testing.

 

Good luck.  

 

[Victoria5289]

On 5/11/2017 at 3:21 PM, sgf743 said:

Hi, 

I'm hoping I can get a bit of guidance here until I get an appointment with a second doctor... I just had a second celiac panel and am confused about my results, as well as my doctor's interpretation. Any help or advice is appreciated, as I am totally new to learning about celiac disease. 

First testing (Oct 2016) 

Gliadin IGA 2.4  (normal range <14.9)

Gliadin IGG 19.2 (normal <14.9)......HIGH

ttG IGA  .5 (normal <14.9)

ttG IGG .8 (normal <14.9)

 

Second testing (May 2017)

Gliadin IGA 1.8 (normal <14.9)

Gliadin IGG 23.7 (normal <14.9).....HIGH (even higher than first test)

ttG IGA .5 (normal <14.9)

ttG IGG .8 (normal <14.9)

 

 

I also tested positive for ANA (autoimmunity), negative rheumatoid arthritis, have an enlarged thyroid (but no hashimotos).  I also experience diarrhea, gas, bloating, acid reflux/heartburn, extreme fatigue all the time, sensitivity to dairy. inflammation markers normal, normal HIDA scan, normal CT scan of abdomen. 

 

Doctor says "unlikely that you have celiac or gluten issues, i believe this positive igg is some sort of cross reaction"  but is unable to explain any further.....trying to research leads me to mixed answers. 

Any advice? 

 

Thank you so much .

 

This test told a story of chromes