Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

deamidated gliadin antibodies 31

John G Smith

Recommended Posts

John G Smith Newbie
John G Smith
Posted

I just had my second blood work done and my deamidated gliadin antibodies have 34 and 31 while the other numbers looked normal.  Please take a look at the attached picture.

My brother was diagnosed with celiac and I have nephews and nieces with the disease.

My gastro doc does not think I have celiac because my only symptoms are fatigue and my other results on the celiac panel are normal.

I just received iron because my iron level was very low. I just had a colonoscopy and did not have any polyps. I don't need to have that done for another 10 years. The oncologist that gave me the iron said that my iron was very low. He said, if he didn't know my colonoscopy was fine, that he would think I had colon cancer based on my paperwork.

I eat a plant based diet and I eat a ton of dark green leafy veggies for iron.

I did have an endoscopy and the doc said the villi looked a little flat but the biopsies were not definitive.

I think everything is pointing to celiac.  I don't want to stop eating gluten if I don't have to. I could have another problem that could be detrimental to my health. 

My genetic report also said I'm at risk for celiac. 

Open Original Shared LinkOpen Original Shared Link
increased risk for celiac disease increased resistance to bacterial infections
 

My concern is, if I don't have celiac, what could I have?

Has anyone seen numbers like this and it was determined that they had celiac?

Thanks for any info.

Thx.

 

John

 

labcorp-cut.webp

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


cyclinglady Grand Master
cyclinglady
Posted
37 minutes ago, John G Smith said:

I just had my second blood work done and my deamidated gliadin antibodies have 34 and 31 while the other numbers looked normal.  Please take a look at the attached picture.

My brother was diagnosed with celiac and I have nephews and nieces with the disease.

My gastro doc does not think I have celiac because my only symptoms are fatigue and my other results on the celiac panel are normal.

I just received iron because my iron level was very low. I just had a colonoscopy and did not have any polyps. I don't need to have that done for another 10 years. The oncologist that gave me the iron said that my iron was very low. He said, if he didn't know my colonoscopy was fine, that he would think I had colon cancer based on my paperwork.

I eat a plant based diet and I eat a ton of dark green leafy veggies for iron.

I did have an endoscopy and the doc said the villi looked a little flat but the biopsies were not definitive.

I think everything is pointing to celiac.  I don't want to stop eating gluten if I don't have to. I could have another problem that could be detrimental to my health. 

My genetic report also said I'm at risk for celiac. 

Open Original Shared LinkOpen Original Shared Link
increased risk for celiac disease increased resistance to bacterial infections
 

My concern is, if I don't have celiac, what could I have?

Has anyone seen numbers like this and it was determined that they had celiac?

Thanks for any info.

Thx.

 

John

 

labcorp-cut.webp

Yes!!!!!!  Me!

Run, don't walk, to another GI who is celiac savvy!!!  

Like you I tested (and still continue to test) the VERY SAME WAY.  Only my DGP IgA is elevated.  All other tests (TTG and EMA IgG and IgA versions) are negative.  There is a reason there is a celiac panel.  The most common and preferred TTG (very good test and due to cost restraints this one is the best to use), catches most but not all celiacs (like you and me).  Like so many things, insurance can drive care!  It is all about the money in so many cases.

Enough of my rant.  Thankfully, your doctor did run a complete panel.  But did he do a good job of obtaining enough intestinal biopsies and at the right locations?  The small intestine is a long tube, but when stretched out it is larger than a tennis court (surface area).  Easy to miss damage locations.  

Here is another item we share.  I was anemic when diagnosed.  No GI issues.  I was shocked since I already have been living with my gluten free hubby.  What are the odds?  

Your result and mine are not common.  I would strongly suggest that you get another opinion and obtain and keep all your medical records, including lab results (and share with another GI).  A positive genetic test, strong family history, elevated celiac antibodies, and a weak biopsy, surely sounds like celiac disease to me, but I am not wearing a white coat.  Get that other opinion!  Keep eating gluten until then.  

Why bother going gluten free?  You don't want to?  Sounds daunting?  Well, my endoscopy revealed a Marsh Stage IIIB.  I had to believe the blood test and the biopsies despite having just low ferritin levels.  (I went in for a colonoscopy for a cancer screening because I am over 50 and my GI suggested celiac testing when he reviewed  my chart).  Guess what?  Ferritin levels increased within months.  No more fatigue.  Bad news?  Fractured two vertabrae just months after my celiac disease diagnosis due to osteoporosis thanks to undiagnosed celiac disease.  You will find that many forum members had other issues resolve that they thought were unrelated to celiac disease.

I wish you well!  

Victoria1234 Experienced
Victoria1234
Posted
1 hour ago, John G Smith said:

the villi looked a little flat

And what else would have caused that, or did he say??? Please take cyclinglady's advice!

 

John G Smith Newbie
John G Smith
Posted
  • Author

Thank you for the replies and detailed information. I'm just happy to read that someone has similar numbers on their blood work.

I am going to look for a doc that specializes in celiac that will take my healthcare. I'm going to probably need a referral from my regular doc. 

Hopefully there won't be a problem since I've already have an endoscopy. 

I just hope a can get a definitive diagnosis. 

Thanks again for the replies.

John

 

 

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      131,902
    • Most Online (within 30 mins)
      7,748
    Patty6133
    Newest Member
    Patty6133
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.4k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Who's Online (See full list)

  • Upcoming Events

  • Posts

    • trents
      New (possible) celiac diagnosis

      By trents · Posted

      Welcome to the forum, @Judy M! Yes, he definitely needs to continue eating gluten until the day of the endoscopy. Not sure why the GI doc advised otherwise but it was a bum steer.  Celiac disease has a genetic component but also an "epigenetic" component. Let me explain. There are two main genes that have been identified as providing the "potential" to develop "active" celiac disease. We know them as HLA-DQ 2.5 (aka, HLA-DQ 2) and HLA-DQ8. Without one or both of these genes it is highly unlikely that a person will develop celiac disease at some point in their life. About 40% of the general population carry one or both of these two genes but only about 1% of the population develops active celiac disease. Thus, possessing the genetic potential for celiac disease is far less than deterministic. Most who have the potential never develop the disease. In order for the potential to develop celiac disease to turn into active celiac disease, some triggering stress event or events must "turn on" the latent genes. This triggering stress event can be a viral infection, some other medical event, or even prolonged psychological/emotional trauma. This part of the equation is difficult to quantify but this is the epigenetic dimension of the disease. Epigenetics has to do with the influence that environmental factors and things not coded into the DNA itself have to do in "turning on" susceptible genes. And this is why celiac disease can develop at any stage of life. Celiac disease is an autoimmune condition (not a food allergy) that causes inflammation in the lining of the small bowel. The ingestion of gluten causes the body to attack the cells of this lining which, over time, damages and destroys them, impairing the body's ability to absorb nutrients since this is the part of the intestinal track responsible for nutrient absorption and also causing numerous other food sensitivities such as dairy/lactose intolerance. There is another gluten-related disorder known as NCGS (Non Celiac Gluten Sensitivity or just, "gluten sensitivity") that is not autoimmune in nature and which does not damage the small bowel lining. However, NCGS shares many of the same symptoms with celiac disease such as gas, bloating, and diarrhea. It is also much more common than celiac disease. There is no test for NCGS so, because they share common symptoms, celiac disease must first be ruled out through formal testing for celiac disease. This is where your husband is right now. It should also be said that some experts believe NCGS can transition into celiac disease. I hope this helps.
    • Judy M
      New (possible) celiac diagnosis

      By Judy M · Posted

      My husband has had lactose intolerance for his entire life (he's 68 yo).  So, he's used to gastro issues. But for the past year he's been experiencing bouts of diarrhea that last for hours.  He finally went to his gastroenterologist ... several blood tests ruled out other maladies, but his celiac results are suspect.  He is scheduled for an endoscopy and colonoscopy in 2 weeks.  He was told to eat "gluten free" until the tests!!!  I, and he know nothing about this "diet" much less how to navigate his in daily life!! The more I read, the more my head is spinning.  So I guess I have 2 questions.  First, I read on this website that prior to testing, eat gluten so as not to compromise the testing!  Is that true? His primary care doctor told him to eat gluten free prior to testing!  I'm so confused.  Second, I read that celiac disease is genetic or caused by other ways such as surgery.  No family history but Gall bladder removal 7 years ago, maybe?  But how in God's name does something like this crop up and now is so awful he can't go a day without worrying.  He still works in Manhattan and considers himself lucky if he gets there without incident!  Advice from those who know would be appreciated!!!!!!!!!!!!
    • Scott Adams
      Patiently Waiting to See Results

      By Scott Adams · Posted

      You've done an excellent job of meticulously tracking the rash's unpredictable behavior, from its symmetrical spread and stubborn scabbing to the potential triggers you've identified, like the asthma medication and dietary changes. It's particularly telling that the rash seems to flare with wheat consumption, even though your initial blood test was negative—as you've noted, being off wheat before a test can sometimes lead to a false negative, and your description of the other symptoms—joint pain, brain fog, stomach issues—is very compelling. The symmetry of the rash is a crucial detail that often points toward an internal cause, such as an autoimmune response or a systemic reaction, rather than just an external irritant like a plant or mites. I hope your doctor tomorrow takes the time to listen carefully to all of this evidence you've gathered and works with you to find some real answers and effective relief. Don't be discouraged if the rash fluctuates; your detailed history is the most valuable tool you have for getting an accurate diagnosis.
    • Scott Adams
      Gluten free beer ?

      By Scott Adams · Posted

      In this case the beer is excellent, but for those who are super sensitive it is likely better to go the full gluten-free beer route. Lakefront Brewery (another sponsor!) has good gluten-free beer made without any gluten ingredients.
    • trents
      Patiently Waiting to See Results

      By trents · Posted

      Welcome to the forum, @catsrlife! Celiac disease can be diagnosed without committing to a full-blown "gluten challenge" if you get a skin biopsy done during an active outbreak of dermatitis herpetiformis, assuming that is what is causing the rash. There is no other known cause for dermatitis herpetiformis so it is definitive for celiac disease. You would need to find a dermatologist who is familiar with doing the biopsy correctly, however. The samples need to be taken next to the pustules, not on them . . . a mistake many dermatologists make when biopsying for dermatitis herpetiformis. 
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.