Not sure how significant gluten sensitivity genes/result is on DNA nutrition report

[BlackShoesBlackSocks]

Hi all,

l'd been looking into the possibility of celiac or gluten sensitivity a few years ago and ultimately wasn't able to have any testing done so l tried to resolve what issues l could on my own (was very underweight) and have tried gluten-free on and off since then.

l did notice some improvement on a gluten free diet as far as chronic migraines which is maybe my primary symptom now, but wasn't sure if  it was worth sustaining if in fact l don't have Celiac or even gluten sensitivity and have tried a few different medications with some success.

Amid Covid, l've been on a bit of a health kick and ordered a nutrition report based on my 23andMe info that included some supplement recommendations and other info. l guess l'm just not sure what the implications of the genes they analyzed have on whether l should get an actual test or take this result seriously.

l've read up a bit on the HLA haplotypes and see that 15-30% of people can have these genes. l didn't realize that if someone does, they may develop celiac disease later in life which is what's throwing me a little...am l supposed to get tested throughout life even if l did get a Celiac panel and test negative  now?

Sorry for the amaetur questions and thanks in advance to anyone who is familiar with the genetic and DNA aspect, from what l understand the genes they analyzed in my data are the "HLA DQ2.2 (M3), HLA DQ2.2 (M2), HLA-DQ 2.5, HLA DQ2.2 (M1), HLA DQ 8" but l'm not sure if the DQ8 was detected since it has no marker next to it like the others.

 

Thanks!

[cyclinglady]

Hi!  Genetic testing is used to help rule out celiac disease and not to diagnose it.  

https://rarediseases.info.nih.gov/diseases/11998/celiac-disease/cases/43805

 If you suspect celiac disease, get the antibody testing from your PCP.   Can you develop later, if your result is negative now?  Yes, if this particular genetic test is accurate.  

I personally do not like this genetic testing.  Who keeps this data?  Do you have disclose this information if you were trying to say, purchase life insurance?  And really, you are limited to two cups of coffee?  Yikes!  Is this even scientifically valid?  

 

[BlackShoesBlackSocks]

9 hours ago, cyclinglady said:

Hi!  Genetic testing is used to help rule out celiac disease and not to diagnose it.  

https://rarediseases.info.nih.gov/diseases/11998/celiac-disease/cases/43805

 If you suspect celiac disease, get the antibody testing from your PCP.   Can you develop later, if your result is negative now?  Yes, if this particular genetic test is accurate.  

I personally do not like this genetic testing.  Who keeps this data?  Do you have disclose this information if you were trying to say, purchase life insurance?  And really, you are limited to two cups of coffee?  Yikes!  Is this even scientifically valid?  

 

Thanks, l couldn't get a screenshot of just the gluten sensitivity result ? As far as the coffee, it messes with me in general and l think is responsible for at least 75% of IBS in my case.

For whatever reason, l was always under the under impression that NGCS wasn't something that could lead to Celiac disease and didn't realize it may share so many of the same genes. So l thought that since kids and even toddlers can test positive for celiac disease, it was something you developed early on and am pretty confident that even if l took l test now, it would probably be negative.

This is making me question whether l'm doing some kind of damage by continuing to eat a gluten containing diet, or could trigger it. l never managed to go gluten free for longer than 3 months because l eventually psyched myself into thinking that maybe l never had any signs of gluten sensitivity anyway, and without a test it's hard to know what to believe.

It's appealing to think it could be a solution to chronic migraines if gluten sensitivity plays a part in my case, and while l did notice some improvement, l'll always have migraine triggers that are also related to weather and other causes so it can be difficult to tell.

 

[cyclinglady]

If you are on a gluten diet (6 to 12 weeks) it might be worth getting tested.  At least rule it out for now.      Migraines are common with those who have celiac disease.  Do a search in the forum for more migraine experiences.  

Anemia was my main symptom.  I once had that IBS diagnosis, which really means “I be stumped”.  Please do not settle.  Try to find the root cause of your issues.  Know that with the genes, you can develop celiac disease even when you are 80 years old!