Blood Test Results Question

[Katie1289]

Hi! I recently did blood testing for celiac disease for the first time, and just received my results. What do these results indicate? My follow up appointment with my doctor isn’t for a month but I wanted to understand what my results are. 
 

any help in interrupting these would be much appreciated! 

 

 

[trents]

"Negative serology" means the blood test that were done did not indicate celiac disease. However, they only did one test, the tTG-IGA test which is the most specific for celiac disease. At the same time, however, the tTG-IGA is the least sensitive of the several tests that can be done to detect celiac disease and so it misses about 1/3 of those who may actually have the disease. This might help: https://celiac.org/about-celiac-disease/screening-and-diagnosis/screening/

That your total IGA levels were in the normal range means that the testing is more likely to give accurate results. When total IGA levels are low, that can skew the results. 

Your test results to this point seem not to point to celiac disease but you could also be gluten sensitive. Although many of the symptoms are the same with celiac disease and gluten sensitivity, the difference is that gluten sensitivity does not damage the villi of the small bowel. Proteins given off by the damage done to the villi are what the tTG-IGA testing measures. 

Do you have more specific questions about your test results?

Edited April 15, 2021 by trents

[Scott Adams]

As @trents mentioned this particular test is negative for celiac disease. Did you have the test done because you have symptoms? If you do have symptoms you may want to do a DPG test, which is another blood test for celiac disease, and/or the genetic test that the results you shared recommends.

Last, there currently isn't a test for non-celiac gluten sensitivity, which ~12% of the population has (only about 1% have celiac disease), so after all testing is completed you may still want to try a gluten-free diet for a few months to see if it relieves any symptoms you may have.