Terrible Neurological Symptoms

[trents]

6 hours ago, Jackie Garrett said:

I believe the lactose intolerance has the same effect on the body as casein intolerance from milk and then histamine reactions occur which causes an acidic environment and then  in SOME cases progressing onto Acidosis or the body just being in an  higher acidic state like I believe like mine was, maybe only a slight change in acid levels is just enough to tip our healths over ??? Because I went on for years never connecting my symptoms to milk I believe my body became acidic, a long time of build up, I then had my Heart attack, so was that a another clue ?? what happened to me and how I recovered made all logical sense to me . . .

You make a lot of questionable connections IMO. Are you familiar with the story of Chicken Little?

Histamine reactions occur which cause an acidic environment?

[Jackie Garrett]

10 hours ago, trents said:

You make a lot of questionable connections IMO. Are you familiar with the story of Chicken Little?

Histamine reactions occur which cause an acidic environment?

Hector, you have a lot of advice from different people on here to go away and think about, I really hope you get the answers you are looking for very soon.

Scott, Trents

when I removed the underlying cause, and found out what Histamine reactions can cause, it all fitted together like a puzzle, it wasn’t Rocket Science, I knew what had happened to my body, I knew what I had to do to get well and I did it, and now I have no more pain no more of my many many life long symptoms. To me that’s Science !!!

[Wheatwacked]

9 hours ago, Jackie Garrett said:

I have no more pain no more of my many many life long symptoms.

Can't argue with that.

Many commonly used drugs can inhibit the production of diamine oxidase (DAO). Many others can liberate stored endogenous histamine. It can also be an inherited trait. Oddly, Benadryl may be one of those that does both.  Drugs that inhibit DAO and or release endogenous stored histamine

The DAO enzyme is dependent on vitamin B6, B12, iron, copper and vitamin C, which are affected by the malabsorption syndrome caused by Celiac Disease.

DAO Deficiency and Histamine  "histamine levels are directly correlated to the vitamin C levels, and intake of vitamin C will lead to less histamine in a matter of days." 

Quote

 

In a healthy person, histamine is broken down by two enzymes: DAO and HNMT. When hen one of these enzymes isn’t working correctly, histamine intolerance can occur.

Conditions such as inflammatory bowel disease, celiac disease, IBS, SIBO increase the risk of histamine intolerance. 

DAO is made in the intestines. If the intestines are not healthy, there may not be enough DAO to break down histamine normally.    https://theceliacmd.com/histamine-intolerance-symptoms-diet-treatment/

 

 

[Wheatwacked]

I love this line:  "People who have limited food variety—including some elderly, indigent individuals who prepare their own food; people who abuse alcohol or drugs; food faddists; people with mental illness; and, occasionally, children—might not obtain sufficient vitamin C"   https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/

Vitamin adequacy is defined as the amount necessary to prevent scurvy. Like the RDA for vitamin D, it's immune and other body functions are disregarded. There is some round about linkage of exercise induced peripheral (due to blood flow) localized histamine levels and neuropathy.  

Quote

The intervention group received 60 mg duloxetine along with 200 mg oral vitamin C. The control group received 60 mg duloxetine without any additional intervention.   The Role of Vitamin C in Reducing Pain Associated With Diabetic Neuropathy

Quote

Dr. Pauling suggested in the early 1970s that the optimum daily intake may be about 2,000 milligrams of vitamin C and that everyone should get at least 200 to 250 mg/day. In a 1974 radio interview, he noted that "the first 250 mg is more important than any later 250 mg.    Pauling Recommendation

Notice that both the histamine and neuropathy issues are possible vitamin C deficiencies. 

[HectorConvector]

So I'm thinking this nerve pain is in some way related to my immune system acting up. This week/weekend I have a sore throat type virus thing going on and that makes the cold spells I get and the nerve pain worse especially in my hands but it's the same type of symptoms, just exaggerated when I have some kind of infection and my immune system is reacting more. 

[knitty kitty]

On 4/9/2022 at 12:14 PM, HectorConvector said:

So I'm thinking this nerve pain is in some way related to my immune system acting up. This week/weekend I have a sore throat type virus thing going on and that makes the cold spells I get and the nerve pain worse especially in my hands but it's the same type of symptoms, just exaggerated when I have some kind of infection and my immune system is reacting more. 

Copper deficiency?

Idiopathic Copper Deficiency Induced Myeloneuropathy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528345/

And...

Burning Foot Syndrome” due to Acute Copper Deficiency Myeloneuropathy after Bariatric Surgery 

https://n.neurology.org/content/92/15_Supplement/P2.6-062

P. S. Take some Vitamin C.  I hope you feel better.  

Do you take a lot of zinc?

Edited April 11, 2022 by knitty kitty
Added post script

[HectorConvector]

2 hours ago, knitty kitty said:

Copper deficiency?

Idiopathic Copper Deficiency Induced Myeloneuropathy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528345/

And...

Burning Foot Syndrome” due to Acute Copper Deficiency Myeloneuropathy after Bariatric Surgery 

https://n.neurology.org/content/92/15_Supplement/P2.6-062

P. S. Take some Vitamin C.  I hope you feel better.  

Do you take a lot of zinc?

Going through my nutrition spreadsheet, I'm getting about 200-250% of the RDA in both zinc and copper. Vit C is 1000mg supplement in addition to the RDA through actual food (usually blueberries for the most part). 

Having cut out dairy products there's been no reduction in nerve pain but its nature has "changed" slightly. That's all that happens if I change what I eat. It's more like burning pain now than it was. I'm also noticing more stabbing upper right quadrant abdominal pain again which has been present only since 2019 when this problem started getting worse.

[shadycharacter]

On 4/4/2022 at 10:31 PM, HectorConvector said:

My neurologist is supposed to have referred me to a dietitian but the referral doesn't seem to have taken place yet (things are a bit slow due to the covid pandemic). Dunno my B12 level at this moment but I'm getting a high level from my diet (900% RDA) and 36000% RDA from a B complex supplement. 

I have had lower back issues for some time, so that's actually a possibility, but not seen a chiropractor yet. 

Hi, 

Just a comment about b12. 36000% of RDA sounds like a lot, but since you only absorb around 1 % of such large amounts, it's not as excessive as it may seem. Some people seem to get symptom relief only from injections but not from oral supplement of that strength (around 1 mg?). Perhaps worth looking into?  B12 is investigated as treatment of nerve pain even in the absence of deficiency:  

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468922/#__ffn_sectitle  

[HectorConvector]

20 hours ago, shadycharacter said:

Hi, 

Just a comment about b12. 36000% of RDA sounds like a lot, but since you only absorb around 1 % of such large amounts, it's not as excessive as it may seem. Some people seem to get symptom relief only from injections but not from oral supplement of that strength (around 1 mg?). Perhaps worth looking into?  B12 is investigated as treatment of nerve pain even in the absence of deficiency:  

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468922/#__ffn_sectitle  

 

Even before I went on my megadose of B12 there was no deficiency indicated from blood tests, could there be nerve problems from this even in absence of deficiency, who knows, but there'd be no way to really prove/disprove it. 

All I know is since I started weight training in particular, the nerve pain has got out of control again it seems. Today is terrible, frequent burning pains and all sorts of rubbish in my feet.  Much worse than last week. This also happened back in 2020 and I had to stop due to extreme pain and loss of sleep. 

I also remember in 2016, the first time I used a leg press machine I overdid it the first time, and had a massive immune response that gave me a huge fever and terrific headache that kept me basically bedridden. It was an abnormally strong reaction for some reason. That's not happened since, but I suspect the catabolism of the muscle from weight training, and my body having problems eliminating muscular waste products, is causing inflammation and immune response making my pain worse. I've also noticed a lot of skin boils appearing in my groin/legs area since training again. A surefire sign of higher inflammation.

[trents]

33 minutes ago, HectorConvector said:

Even before I went on my megadose of B12 there was no deficiency indicated from blood tests, could there be nerve problems from this even in absence of deficiency, who knows, but there'd be no way to really prove/disprove it. 

All I know is since I started weight training in particular, the nerve pain has got out of control again it seems. Today is terrible, frequent burning pains and all sorts of rubbish in my feet.  Much worse than last week. This also happened back in 2020 and I had to stop due to extreme pain and loss of sleep. 

I also remember in 2016, the first time I used a leg press machine I overdid it the first time, and had a massive immune response that gave me a huge fever and terrific headache that kept me basically bedridden. It was an abnormally strong reaction for some reason. That's not happened since, but I suspect the catabolism of the muscle from weight training, and my body having problems eliminating muscular waste products, is causing inflammation and immune response making my pain worse. I've also noticed a lot of skin boils appearing in my groin/legs area since training again. A surefire sign of higher inflammation.

Perhaps you have trouble breaking down lactic acid.

[HectorConvector]

46 minutes ago, trents said:

Perhaps you have trouble breaking down lactic acid.

That seems like a possibility based on what's been said on here, and I'll mention this to my neurologist when I see him again in the summer (he can then refer me to whatever tests required). With things like cycling, I can get right into my anaerobic zone regularly where I'll get lactate build up in my legs, but never had an increase in nerve pain while doing so. Seems like weight training is the only thing that really exacerbates it, it's probably producing a whole lot more lactic acid. 

Generally, my muscles seem to recover fast between sets with the weight training, usually I'm waiting to catch my breath back.  I do high repetitions (as much as 50 sometimes in one set) for heavy exercises like squats, and obviously, this is going to cause a lot of lactic acid build up. The pain itself, in the nerves is like typical stabbing and crushing pains in the stocking and glove pattern, at any time of day or night. It doesn't feel like the muscle burn when I exercise, but is more brief and sudden, usually quite startling when it happens. The pain gets worse with a latency from when I train, so gradually in the weeks after I start training, for example. 

[Jackie Garrett]

16 hours ago, HectorConvector said:

That seems like a possibility based on what's been said on here, and I'll mention this to my neurologist when I see him again in the summer (he can then refer me to whatever tests required). With things like cycling, I can get right into my anaerobic zone regularly where I'll get lactate build up in my legs, but never had an increase in nerve pain while doing so. Seems like weight training is the only thing that really exacerbates it, it's probably producing a whole lot more lactic acid. 

Generally, my muscles seem to recover fast between sets with the weight training, usually I'm waiting to catch my breath back.  I do high repetitions (as much as 50 sometimes in one set) for heavy exercises like squats, and obviously, this is going to cause a lot of lactic acid build up. The pain itself, in the nerves is like typical stabbing and crushing pains in the stocking and glove pattern, at any time of day or night. It doesn't feel like the muscle burn when I exercise, but is more brief and sudden, usually quite startling when it happens. The pain gets worse with a latency from when I train, so gradually in the weeks after I start training, for example. 

Hector why you have this problem of such pain, after certain workouts, maybe you could be over doing it, and it’s too much for your body, and its releasing too much acid from your muscles, just a thought ?? Here is an article I came across.

[Jackie Garrett]

18 hours ago, HectorConvector said:

That seems like a possibility based on what's been said on here, and I'll mention this to my neurologist when I see him again in the summer (he can then refer me to whatever tests required). With things like cycling, I can get right into my anaerobic zone regularly where I'll get lactate build up in my legs, but never had an increase in nerve pain while doing so. Seems like weight training is the only thing that really exacerbates it, it's probably producing a whole lot more lactic acid. 

Generally, my muscles seem to recover fast between sets with the weight training, usually I'm waiting to catch my breath back.  I do high repetitions (as much as 50 sometimes in one set) for heavy exercises like squats, and obviously, this is going to cause a lot of lactic acid build up. The pain itself, in the nerves is like typical stabbing and crushing pains in the stocking and glove pattern, at any time of day or night. It doesn't feel like the muscle burn when I exercise, but is more brief and sudden, usually quite startling when it happens. The pain gets worse with a latency from when I train, so gradually in the weeks after I start training, for example. 

https://www.hopkinsmedicine.org/orthopaedic-surgery/about-us/ask-the-experts/pain.html

[HectorConvector]

2 hours ago, Jackie Garrett said:

https://www.hopkinsmedicine.org/orthopaedic-surgery/about-us/ask-the-experts/pain.html

That seems to talk about bone and muscle pains, whereas I'm getting neuropathic stocking/glove nerve pains in feet/hands only, so I'm not sure how the connection works here, and for example, my pain doesn't immediately follow a specific workout, it gets gradually worse the longer I've been doing them. Bear in mind, I had this pain before I ever did many sort of workouts, from 2009/2010, but it was just very mild. 

When you say "releasing too much acid" for my muscles, what do you mean? Because lactate acid build-up when doing anaerobic exercise is normal, and mine seems to be at levels expected for such exercises. The vast majority of people doing these exercises have no nerve pain issues, but they also didn't have nerve issues before starting working out. It seems to me, that I have a pre-existing condition, and that the workouts are exacerbating it - my muscles themselves are working normally - but something is attacking the nerves, and what it is remains unknown. The increase in lactate, though normal for these exercises, might be causing further problems to my pre-existing condition, but it seems like the real underlying issue of the pre-existing nerve problem is what needs addressing, rather than avoiding things like weight training or lactate stimulating anaerobic exercises, as those are beneficial for health and I do no more (possibly less) than the WHO recommended amounts for adults already.

[Jackie Garrett]

34 minutes ago, HectorConvector said:

That seems to talk about bone and muscle pains, whereas I'm getting neuropathic stocking/glove nerve pains in feet/hands only, so I'm not sure how the connection works here, and for example, my pain doesn't immediately follow a specific workout, it gets gradually worse the longer I've been doing them. Bear in mind, I had this pain before I ever did many sort of workouts, from 2009/2010, but it was just very mild. 

When you say "releasing too much acid" for my muscles, what do you mean? Because lactate acid build-up when doing anaerobic exercise is normal, and mine seems to be at levels expected for such exercises. The vast majority of people doing these exercises have no nerve pain issues, but they also didn't have nerve issues before starting working out. It seems to me, that I have a pre-existing condition, and that the workouts are exacerbating it - my muscles themselves are working normally - but something is attacking the nerves, and what it is remains unknown. The increase in lactate, though normal for these exercises, might be causing further problems to my pre-existing condition, but it seems like the real underlying issue of the pre-existing nerve problem is what needs addressing, rather than avoiding things like weight training or lactate stimulating anaerobic exercises, as those are beneficial for health and I do no more (possibly less) than the WHO recommended amounts for adults already.

Hector

You have this underlying condition, that you have yet to find out what it is, it seems to me that you do a lot of exercising and quite strenuous, it may be a normal amount for a healthy adult with no underlying problem, but you do have an underlying problem and it may be a bit too much for your body, have you had your lactate levels checked at all ? Are you still avoiding Dairy, you will have to give it enough time, it may or may not be in your case, but it was in my case. The sooner you can get tested for your lactate levels the better really then you can rule things out. Maybe it’s down to a build up of proteins and your body is not getting rid of these and you need a bit of a detox for a while, these are just suggestions, you need a good Dr. Who is willing to do lots of tests on you. 

[shadycharacter]

1 hour ago, HectorConvector said:

That seems to talk about bone and muscle pains, whereas I'm getting neuropathic stocking/glove nerve pains in feet/hands only, so I'm not sure how the connection works here, and for example, my pain doesn't immediately follow a specific workout, it gets gradually worse the longer I've been doing them. Bear in mind, I had this pain before I ever did many sort of workouts, from 2009/2010, but it was just very mild. 

When you say "releasing too much acid" for my muscles, what do you mean? Because lactate acid build-up when doing anaerobic exercise is normal, and mine seems to be at levels expected for such exercises. The vast majority of people doing these exercises have no nerve pain issues, but they also didn't have nerve issues before starting working out. It seems to me, that I have a pre-existing condition, and that the workouts are exacerbating it - my muscles themselves are working normally - but something is attacking the nerves, and what it is remains unknown. The increase in lactate, though normal for these exercises, might be causing further problems to my pre-existing condition, but it seems like the real underlying issue of the pre-existing nerve problem is what needs addressing, rather than avoiding things like weight training or lactate stimulating anaerobic exercises, as those are beneficial for health and I do no more (possibly less) than the WHO recommended amounts for adults already.

Could oxidative stress be a common factor for pain after meals and pain after exercise, if your nerves are extra sensitive?

[HectorConvector]

24 minutes ago, Jackie Garrett said:

Hector

You have this underlying condition, that you have yet to find out what it is, it seems to me that you do a lot of exercising and quite strenuous, it may be a normal amount for a healthy adult with no underlying problem, but you do have an underlying problem and it may be a bit too much for your body, have you had your lactate levels checked at all ? Are you still avoiding Dairy, you will have to give it enough time, it may or may not be in your case, but it was in my case. The sooner you can get tested for your lactate levels the better really then you can rule things out. Maybe it’s down to a build up of proteins and your body is not getting rid of these and you need a bit of a detox for a while, these are just suggestions, you need a good Dr. Who is willing to do lots of tests on you. 

I've only done much exercising since February this year, and before that it was in late 2019 to May 2020, when I had to stop due to nerve pain. My neurologist will arrange for me to get lactate levels checked, when I next speak to him. Yes, I've avoided dairy products now since I believe, 6th April. Build up of protein, I'm not sure what that means, tbh, what proteins does the body need to get rid of? You mean waste products from protein metabolism? When weight training, muscle catabolism occurs, as the fibres are stressed, which increases the amount of waste products released into the blood, though it's normal and shouldn't cause nerve pain problems, but then again I clearly have some nerve problem.

Or perhaps you're referring to conditions where abnormal proteins are produced (usually due to a DNA error) called Amyloid, which can cause neuropathy? Amyloidosis is one thing that hasn't been officially ruled out yet.

On the matter of protein generally, however, higher protein/fat and lower carb foods greatly improve my symptoms. My body reacts aggressively to higher carb foods, especially. 

18 minutes ago, shadycharacter said:

Could oxidative stress be a common factor for pain after meals and pain after exercise, if your nerves are extra sensitive?

It could be - in which case it would appear to be another one of many "triggers" for my nerve pain, which has some unidentified underlying cause. 

[Jackie Garrett]

25 minutes ago, HectorConvector said:

I've only done much exercising since February this year, and before that it was in late 2019 to May 2020, when I had to stop due to nerve pain. My neurologist will arrange for me to get lactate levels checked, when I next speak to him. Yes, I've avoided dairy products now since I believe, 6th April. Build up of protein, I'm not sure what that means, tbh, what proteins does the body need to get rid of? You mean waste products from protein metabolism? When weight training, muscle catabolism occurs, as the fibres are stressed, which increases the amount of waste products released into the blood, though it's normal and shouldn't cause nerve pain problems, but then again I clearly have some nerve problem.

Or perhaps you're referring to conditions where abnormal proteins are produced (usually due to a DNA error) called Amyloid, which can cause neuropathy? Amyloidosis is one thing that hasn't been officially ruled out yet.

On the matter of protein generally, however, higher protein/fat and lower carb foods greatly improve my symptoms. My body reacts aggressively to higher carb foods, especially. 

It could be - in which case it would appear to be another one of many "triggers" for my nerve pain, which has some unidentified underlying cause. 

The proteins that are from red meat and dairy, if your body is not processing them properly you may have a build up, I didn’t connect my build up as I was tolerating them for years it was when I made the connection and I removed the Dairy I got better, so although you say you don’t have a problem you may have and it could be invisible cause, like mine was, is it the underlying cause ??? I eat meat but smaller amounts now, as I want to reduce my protein intake, Dairy was my invisible cause for many, many years. Maybe you might be able to tolerate carbs more if you reduce your Protein intake it’s just a thought!!! 

[HectorConvector]

58 minutes ago, Jackie Garrett said:

The proteins that are from red meat and dairy, if your body is not processing them properly you may have a build up, I didn’t connect my build up as I was tolerating them for years it was when I made the connection and I removed the Dairy I got better, so although you say you don’t have a problem you may have and it could be invisible cause, like mine was, is it the underlying cause ??? I eat meat but smaller amounts now, as I want to reduce my protein intake, Dairy was my invisible cause for many, many years. Maybe you might be able to tolerate carbs more if you reduce your Protein intake it’s just a thought!!! 

What clinical means are there to find out if I'm not processing this properly? Excess protein that's not being processed properly will appear as proteinuria in the urine, which I've not had any indication of clinically, but I can always get another urine test. 

When I say "tolerate" carbs, I mean I'm just talking their effect on my nerve pain. My body can handle them fine from the blood sugar point of view, and my protein intake seems to not have made any difference to this over the years. It was the nerve pain made worse by carbs that made me increase the levels of fat and protein in my diet in the first place, otherwise my nerve pain would be far worse - it got that way in late 2019, when I went high carb for my weight training, and got such violent neuropathy I was actually terrified. I immediately ditched all the carbs and replaced it with protein that day, it scared me so badly. The pain went away almost immediately. 

Also, the science I've seen seems to suggest that higher protein diets improve carb tolerance, rather than the other way around, at least in relation to diabetics (though I don't have that officially anyway).

https://drc.bmj.com/content/4/1/e000258

[Jackie Garrett]

1 hour ago, HectorConvector said:

What clinical means are there to find out if I'm not processing this properly? Excess protein that's not being processed properly will appear as proteinuria in the urine, which I've not had any indication of clinically, but I can always get another urine test. 

When I say "tolerate" carbs, I mean I'm just talking their effect on my nerve pain. My body can handle them fine from the blood sugar point of view, and my protein intake seems to not have made any difference to this over the years. It was the nerve pain made worse by carbs that made me increase the levels of fat and protein in my diet in the first place, otherwise my nerve pain would be far worse - it got that way in late 2019, when I went high carb for my weight training, and got such violent neuropathy I was actually terrified. I immediately ditched all the carbs and replaced it with protein that day, it scared me so badly. The pain went away almost immediately. 

Also, the science I've seen seems to suggest that higher protein diets improve carb tolerance, rather than the other way around, at least in relation to diabetics (though I don't have that officially anyway).

https://drc.bmj.com/content/4/1/e000258

I just can’t think what it could be, 

 

1 hour ago, HectorConvector said:

What clinical means are there to find out if I'm not processing this properly? Excess protein that's not being processed properly will appear as proteinuria in the urine, which I've not had any indication of clinically, but I can always get another urine test. 

When I say "tolerate" carbs, I mean I'm just talking their effect on my nerve pain. My body can handle them fine from the blood sugar point of view, and my protein intake seems to not have made any difference to this over the years. It was the nerve pain made worse by carbs that made me increase the levels of fat and protein in my diet in the first place, otherwise my nerve pain would be far worse - it got that way in late 2019, when I went high carb for my weight training, and got such violent neuropathy I was actually terrified. I immediately ditched all the carbs and replaced it with protein that day, it scared me so badly. The pain went away almost immediately. 

Also, the science I've seen seems to suggest that higher protein diets improve carb tolerance, rather than the other way around, at least in relation to diabetics (though I don't have that officially anyway).

https://drc.bmj.com/content/4/1/e000258

Maybe make a list of all the tests you would like to have done and. give to your Dr. and hopefully you may get some answers. Take care.

[HectorConvector]

3 minutes ago, Jackie Garrett said:

I just can’t think what it could be, 

 

Maybe make a list of all the tests you would like to have done and. give to your Dr. and hopefully you may get some answers. Take care.

My main suspicion is something like an autoimmune reaction of some kind causing the nerve damage. I'm going to have a list of tests I'd like done yes. Should be seeing the neurologist in summer. 

[Jackie Garrett]

1 minute ago, HectorConvector said:

My main suspicion is something like an autoimmune reaction of some kind causing the nerve damage. I'm going to have a list of tests I'd like done yes. Should be seeing the neurologist in summer. 

Good luck Hector .

[Wheatwacked]

10 hours ago, HectorConvector said:

autoimmune reaction of some kind causing the nerve damage

I know you are already taking vitamin D. Try doubling it. Twice a day would smooth the peaks, your body will after a few days recognize the increased amount and start storing the excess.  Part of the adaptation allowing us to move from the equator. Target blood plasma above 70 ng/ml. Prior to the industrial revolution we spent most of our days outside, without sunscreen.

Go with Dr Pauling's advice for 2000 mg a day. He made this recommendation without the input of the medical boards, lawyers and accountants.

[HectorConvector]

5 hours ago, Wheatwacked said:

I know you are already taking vitamin D. Try doubling it. Twice a day would smooth the peaks, your body will after a few days recognize the increased amount and start storing the excess.  Part of the adaptation allowing us to move from the equator. Target blood plasma above 70 ng/ml. Prior to the industrial revolution we spent most of our days outside, without sunscreen.

Go with Dr Pauling's advice for 2000 mg a day. He made this recommendation without the input of the medical boards, lawyers and accountants.

I'm currently still taking 4,000iu per day.

[Wheatwacked]

You could safely triple it.

Vitamin D Is Not as Toxic as Was Once Thought: A Historical and an Up-to-Date Perspective   "Vitamin D intoxication associated with hypercalcemia, hyperphosphatemia, and suppressed parathyroid hormone level is typically seen in patients who are receiving massive doses of vitamin D in the range of 50,000 to 1 million IU/d for several months to years."

Vitamin D and the Immune System

Vitamin D for the treatment of painful diabetic neuropathy    "Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic neuropathy."

Evaluation of vitamin D levels in patients with chronic low back-leg pain

Could it be Sciatica? 

Quote

 

You are at greater risk of sciatica if you: Have an injury/previous injury: An injury to your lower back or spine puts you at greater risk for sciatica. Lack proper posture in the weight room: Even if you are physically fit and active, you can still be prone to sciatica if you don’t follow proper body form during weightlifting or other strength training exercises.

Some people describe the pain as sharp, shooting, or jolts of pain. Others describe this pain as “burning,” "electric” or “stabbing.”

The pain may be constant or may come and go. Also, the pain is usually more severe in your leg compared to your lower back.  The pain may feel worse if you sit or stand for long periods of time, when you stand up and when your twist your upper body. A forced and sudden body movement, like a cough or sneeze, can also make the pain worse.   https://my.clevelandclinic.org/health/diseases/12792-sciatica

 

 

Edited April 15, 2022 by Wheatwacked