Dna Results In

[angelschick]

I just got my genetic test in and I am very confused. Can somone explain this to me in English?

HLA-DQB1 Molecular analysis, Allele 1 0501

HLA-DQB1 Molecular analysis, Allele 2 0604

Serologic equivalent: HLA-DQ 1,1 (Subtype 5,6)

So if hubby is reading this right, I do not possess the gene for celiac. Am I in the clear then and just have a sensitivity?

Confused as usual....

Amy

[Mother of Jibril]

Hi Amy,

Your husband is right that you don't have one of the main genes for celiac disease (DQ2 or DQ8). However... you do have a double dose of serotype DQ1 (you have a combination of subtypes DQ5 and DQ6). Serotype DQ1 is associated with neurological problems such as ataxia, MS, vertigo, depression, etc...

Wikipedia (Open Original Shared Link) says that DQ5 gives protection against Addisons's disease (this is a good thing!), but makes you susceptible to aneurysms, IBS, Chron's disease, and intolerance to analgesics (pain medications).

Hope this helps!

[angelschick]

Hi Amy,

Your husband is right that you don't have one of the main genes for celiac disease (DQ2 or DQ8). However... you do have a double dose of serotype DQ1 (you have a combination of subtypes DQ5 and DQ6). Serotype DQ1 is associated with neurological problems such as ataxia, MS, vertigo, depression, etc...

Wikipedia (Open Original Shared Link) says that DQ5 gives protection against Addisons's disease (this is a good thing!), but makes you susceptible to aneurysms, IBS, Chron's disease, and intolerance to analgesics (pain medications).

Hope this helps!

It does help but now I'm even more confused. I was *SURE* I had celiac disease but the genetics say otherwise. So why would a non-celiac's LOW cholesterol finally go up after going gluten-free? I just don't understand......

[Mother of Jibril]

You could be one of those rare people that has celiac disease without DQ2 or DQ8... check out the profile of ravenwoodglass.

Also... you don't need to have celiac disease to have problems with malabsorption. Look at some websites about Chron's, for example. That's another autoimmune disorder that affects the intestines and interferes with proper digestion. If you feel better being off gluten, then do that! Nobody says you have to eat it

[ravenwoodglass]

The lack of DQ2 or DQ8 is not conclusive in the elimination of the possibility of having celiac. Those are the most common ones, as far as US is concerned, but there are now 7 more genes that are recognized as being 'celiac' genes in other countries. You can definately still have full blown celiac.

[Jestgar]

It does help but now I'm even more confused. I was *SURE* I had celiac disease but the genetics say otherwise. So why would a non-celiac's LOW cholesterol finally go up after going gluten-free? I just don't understand......

The "Celiac genes" have not been shown to cause Celiac. They are only markers. If you don't have the marker, that doesn't mean that you don't have the genes(s) that cause Celiac.

[fedora]

just curious,

what are your symptoms?

I aske because those are my daughter's genes

[angelschick]

I saw an "allergist" today who specializes in and HAS celiac. She says best case scenario I have a bad gluten sensitivity, maybe even celiac. She said my genes alone cannot rule out celiac. So - she has ordered a biopsy and a full celiac panel.I will know Monday when it is.

Fedora - my symptoms are - PAIN (LOTS of it) in mostly back and left hip but all joints, exhausted, LOW cholesterol (that went up when I went gluten-free for a few weeks), bloating, D which is fatty (YUCK!), Constipated, gas, my fingers and toes are often numb, no hormones to speak of, odd red rash (NON-DH) under my chin, hashimoto's, always hungry, high heart rate (resting in 90's), carpel tunnel, get dizzy when i stand up at times.

[glutenfreemaryland]

The enterolab webpage has lots of information on understanding gene testing. The gene testing results are most useful if the result is that you do not possess the genes associated with celiac - then I believe that means you are in the clear. When my daughter was tested b/c I have celiac disease, we found she has two genes associated with celiac disease. According to enterolab and her doctor, all this means is that there is a chance that she may develp celiac disease someday. Many people with the genes never develop it. We would told to just have her primary physician order the blood test every two years.