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Should I Have Been Eating Gluten Prior To These Tests?


KevinG

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KevinG Apprentice

My gastroenterologist ordered some blood tests for celiac; my results are below. His nurse told me based on the results that I don't have celiac and am not at risk for developing it. However, I had been on a gluten-free diet for months prior to the tests. (Occasionally some gluten slips in, but I am pretty careful.) Does that render the below tests invalid?

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psawyer Proficient

Your results are negative for antibodies related to celiac disease, but if you have not been eating gluten then there will not be antibodies--at least not enough to register on the test. I was retested a few years ago, and everything was normal. Does that mean that I no longer have celiac disease? NO! It means that I have been very successful in following the gluten-free diet, and there is not any gluten in my food to trigger the autoimmune response. :)

txplowgirl Enthusiast

You need to be eating the equivelant of 2 to 3 slices of bread a day for about 2 months or longer for any chance of a positive test.

Mari Enthusiast

It looks like you have one or two HLA DQ 2 markers and that means that you are predisposed to developing Celiac Disease. I can't tell exactly what test they did - they call it a molecular test which may not mean they actually determined which DQ allele(s) you inherited so we can't tell whether you are high risk or low risk. Call the lab which did the test and ask them to tell you what it means and if you would get more information if you had the DNA marker test.

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    • trents
      Let me hasten to add that if you will be undergoing an endoscopy/biopsy, it is critical that you do not begin efforts to reduce gluten beforehand. Doing so will render the results invalid as it will allow the small bowel lining to heal and, therefore, obscure the damage done by celiac disease which is what the biopsy is looking for.
    • Scott Adams
      This article, and the comments below it, may be helpful:    
    • Scott Adams
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    • Greymo
      https://celiac.org/glutenexposuremarkers/    yes, two hours after accidents ingesting gluten I am vomiting and then diarrhea- then exhaustion and a headache. see the article above- There is research that shows our reactions.
    • trents
      Concerning the EMA positive result, the EMA was the original blood test developed to detect celiac disease and has largely been replaced by the tTG-IGA which has a similar reliability confidence but is much less expensive to run. Yes, a positive EMA is very strong evidence of celiac disease but not foolproof. In the UK, a tTG-IGA score that is 10x normal or greater will often result in foregoing the endoscopy/biopsy. Weaker positives on the tTG-IGA still trigger the endoscopy/biopsy. That protocol is being considered in the US but is not yet in place.
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