Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Biospy Report Help With Understanding It

TJ060306

Recommended Posts

TJ060306 Apprentice
TJ060306
Posted

Hi I had a endoscopy on 12/21 and I got the results on Friday. I have had one positive and one negative biospy in the past year and neg bloodwork. These results I think are another positive. I was just looking for someone elses input as I think I have celiac and I really wish my doc would see it too, but since my bloodwork is negative he doesnt want to see it.

Part 1:Duodenal Biospies:

Fragments of duodenal mucosa with areas of villious blunting, intraepithelial lymphocytes, along with acute and chronic duodenitis.

Note: Although nonspecific, these findings may be associated with celiac diease.

Part 2: Gastric biospies:

Fragments of gastric fundic and antral muscosa with chronic inflammation along with areas of regenerative/reactive glandular atypia.

Note: No organisms suggestive of H. pylori seen on Alcian yellow stain.

Part 3: Esophageal biospies:

Fragments of esophageal squamous mucosa with basal layer hyperplasia and slight subacute and moderate chronic inflammation.

Note: No obvious intestinal metaplasia seen on H E or Alcian blue stains. There are between 5 and 10 eosinophils per selected high power field. Clinical and endoscopic correlation recommended for evalutaion of eosinophilic esophagitis.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Takala Enthusiast
Takala
Posted

Well.... you may not be walking like a duck, but your gut is quacking like one.... welcome to the forum, never officially diagnosed division. B)

IrishHeart Veteran
IrishHeart
Posted

Since increased intraepithelial lymphocytes are associated with early stage celiac (marsh 1, for example)

AND villous blunting is certainly a celiac symptom

AND you have chronic inflammation

AND you already had a POSITIVE biopsy (geesh, how many biopsies are they going to put you through?? :blink: )

it sure would make me think I have Celiac.

MANY people have NEGATIVE blood work and positive biopsies. What's your doc's problem here????? :rolleyes:

As TAKALA says, if it walks like a duck and quacks like a duck..... :)

psawyer Proficient
psawyer
Posted

Short answer: You have Celiac Disease.

maramelia Newbie
maramelia
Posted

Hi I had a endoscopy on 12/21 and I got the results on Friday. I have had one positive and one negative biospy in the past year and neg bloodwork. These results I think are another positive. I was just looking for someone elses input as I think I have celiac and I really wish my doc would see it too, but since my bloodwork is negative he doesnt want to see it.

Part 1:Duodenal Biospies:

Fragments of duodenal mucosa with areas of villious blunting, intraepithelial lymphocytes, along with acute and chronic duodenitis.

Note: Although nonspecific, these findings may be associated with celiac diease.

Part 2: Gastric biospies:

Fragments of gastric fundic and antral muscosa with chronic inflammation along with areas of regenerative/reactive glandular atypia.

Note: No organisms suggestive of H. pylori seen on Alcian yellow stain.

Part 3: Esophageal biospies:

Fragments of esophageal squamous mucosa with basal layer hyperplasia and slight subacute and moderate chronic inflammation.

Note: No obvious intestinal metaplasia seen on H E or Alcian blue stains. There are between 5 and 10 eosinophils per selected high power field. Clinical and endoscopic correlation recommended for evalutaion of eosinophilic esophagitis.

Hi TJ.

Usually, in the AP report, the most important part i that of the duodenal biopsy --- and usually the doctors / pathologists describe those duodenal biopsies with more exactly numbers, to better understand if you have or not an enteropathy: "areas of villious blunting" - usually they write if the ratio vili/cripts is 3:1, 2:1, or less than this, or more than this... "intraepithelial lymphocytes" - usually the normal rate is 20-25 per 100 epithelial cells, depending on your age, its better to describe the number of intraepithelial lynphocytes that were finded... Did you get?

If you read some of those numbers on your report, fell free to tell me!!! With that information, it is better to grade the stage of your disease. But im sure that you may have some pathological signs (remember - they all are not specific) of celiac disease - the duodenitis, the vili blunting, and, depending on the number of intraepithelial lynphocytes, also inflamatory intracellular reaction - changes.

rgds mara

TJ060306 Apprentice
TJ060306
Posted
  • Author

Hi all!

Thanks for the responses but the doctor decied since this is the second positve in a year that it 'must' celiac! So he said to try a gluten free diet! woooo whoo!!! thanks it has been a long 2 years!

IrishHeart Veteran
IrishHeart
Posted

So glad he saw it "our" way :lol:

(Geesh, the 1st one should have been enough)

Welcome to the club! Enjoy your new healthy life OFF gluten!

Best wishes!!

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


domesticactivist Collaborator
domesticactivist
Posted

Congrats on your diagnosis. Sounds like it was a long time coming! Now the good part... Getting healthy :)

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. cristiana
      - cristiana replied to Colleen H's topic in Gluten-Free Foods, Products, Shopping & Medications
      16

      Ibuprofen

      Ferritin levels. And see what your hemoglobin looks like too, that will tell you if you are anemic? You can have 'low normal' levels that will not be flagged by blood tests. I had 'low normal' levels, my lab reading was. c12, just over what was considered normal, but I had small benign lesion on my tongue, and sometimes a sore mouth, and a consultant maxillofacial...
    2. Mari
      - Mari replied to KathyR37's topic in Coping with Celiac Disease
      5

      New here

      Hi Katht - I sympathize with your struggles in following a gluten-free diet and lifestyle. I found out that I had Celiac Disease a few months before I turned 70. I just turned 89 and it has taken me almost 20 years to attain a fairly normal intestinal function. I also lost a lot of weight, down to 100 lb. down from about 140 lb. What Trents wrote you was...
    3. Colleen H
      - Colleen H replied to Colleen H's topic in Gluten-Free Foods, Products, Shopping & Medications
      16

      Ibuprofen

      Yes thyroid was tested.. negative Iron ...I'm. Not sure ... Would that fall under red blood count? If so I was ok Thank you for the detailed response..☺️
    4. Colleen H
      - Colleen H posted a topic in Coping with Celiac Disease
      0

      Methylprednisone treatment for inflammation?

      Hi all !! Did anyone ever get prescribed methylprednisone steroids for inflammation of stomach and intestines? Did it work ?? Thank you !!
    5. cristiana
      - cristiana replied to Colleen H's topic in Gluten-Free Foods, Products, Shopping & Medications
      16

      Ibuprofen

      Hi Colleen Are you supplementing B12/having injections? I have learned recently that sometimes when you start addressing a B12 deficiency, it can temporarily make your symptoms worse. But it is important not to stop the treatment. Regarding your problems with anxiety, again that is another symptom of a B12 deficiency. I didn't know...
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      131,879
    • Most Online (within 30 mins)
      7,748
    Peta Dunn
    Newest Member
    Peta Dunn
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.4k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • cristiana
      Ibuprofen

      By cristiana · Posted

      Ferritin levels.  And see what your hemoglobin looks like too, that will tell you if you are anemic?  You can have 'low normal' levels that will not be flagged by blood tests.  I had 'low normal' levels, my lab reading was. c12, just over what was considered normal, but I had small benign lesion on my tongue, and sometimes a sore mouth, and a consultant maxillofacial ordered an iron infusion for me as he felt my levels were too low and if he  raised them to 40, it would help.   Because you are not feeling 100% it might be worth looking at your levels, then discussing with your doctor if they are low normal.  But I stress, don't supplement iron without your levels being monitored, too much is dangerous.
    • Mari
      New here

      By Mari · Posted

      Hi Katht -  I sympathize with your struggles in following a gluten-free diet and lifestyle. I found out that I had Celiac Disease a few months before I turned 70. I just turned 89 and it has taken me almost 20 years to attain a fairly normal intestinal  function. I also lost a lot of weight, down to 100 lb. down from about 140 lb. What Trents wrote you was very true for me. I am still elimination foods from my diet. One person suggested you keep a food diary and that is a good idea but it is probably best just to do an elimination diet. There are several ne and maybe one for celiacs. I used one for a while and started with plain rice and zucchini and then added back other foods to see if I reacted or not. That helped a great deal but what I did not realise that it would only very small amounts of some foods to cause inflammation in my intestine. Within the last few years I have stopped eating any trace amounts of hot peppers, corn and soy(mostly in supplements) and nuts, (the corn in Tylenol was giving me stomach aches and the nuts were causing foot pains). Starting an elimination diet with white rice is better than brown rice that has some natural toxins. In addition it is very important to drink sufficient plain water. You can find out how much to drink for your height and weight online. I do have difficulty drinking 48 ounces of water but just recently have found an electrolyte supplement that helps me stay well hydrated, Adding the water and electrolytes may reduce muscle cramps and gag spams you wrote about. . Also buy some anti-gluten enzyme capsules to take with meals. I use GliadinX advertised here. These are a lot of things to do at one time as they reflect my 20 years of experience. I hope you do what you can manage to do over time. Good luck and take care.
    • Colleen H
      Ibuprofen

      By Colleen H · Posted

      Yes thyroid was tested.. negative  Iron ...I'm. Not sure ... Would that fall under red blood count?  If so I was ok  Thank you for the detailed response..☺️
    • Colleen H
      Methylprednisone treatment for inflammation?

      By Colleen H · Posted

      Hi all !! Did anyone ever get prescribed methylprednisone steroids for inflammation of stomach and intestines?  Did it work ??  Thank you !! 
    • cristiana
      Ibuprofen

      By cristiana · Posted

      Hi Colleen Are you supplementing B12/having injections? I have learned recently that sometimes when you start addressing a B12 deficiency, it can temporarily make your symptoms worse.  But it is important not to stop the treatment.  Regarding your problems with anxiety, again that is another symptom of a B12 deficiency.   I didn't know what anxiety was until it hit me like a train several months before gastrointestinal issues began, so I can certainly relate.   Two books which helped me hugely were At Last A Life by Paul David (there is a website you can look up) and The Depression Cure: The Six-Step Programme to Beat Depression Without Drugs by Dr Steve Llardi.  Although his book is aimed at people who have depression, following the principals he sets out was so helpful in lessening my anxiety.  Llardi suggests we need to focus on getting enough: - physical exercise - omega-3 fatty acids - natural sunlight exposure - restorative sleep - social connectedness - meaningful, engaging activity   ... and we should feel a lot better. That is not to stay you must stop taking medication for depression or anxiety if you have been prescribed it, but adopting the changes Dr Llardi sets out in the book should really help. Can I just ask two more questions:  1) you say that you are B12 deficient, did they test your iron levels too?  If not, you really ought to be checked for deficiency and, 2) did they check your thyroid function, as an overactive thyroid can be cause rapid heartbeat and a lot of coeliacs have thyroid issues? Cristiana        
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.