Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Biospy Report Help With Understanding It

TJ060306

Recommended Posts

TJ060306 Apprentice
TJ060306
Posted

Hi I had a endoscopy on 12/21 and I got the results on Friday. I have had one positive and one negative biospy in the past year and neg bloodwork. These results I think are another positive. I was just looking for someone elses input as I think I have celiac and I really wish my doc would see it too, but since my bloodwork is negative he doesnt want to see it.

Part 1:Duodenal Biospies:

Fragments of duodenal mucosa with areas of villious blunting, intraepithelial lymphocytes, along with acute and chronic duodenitis.

Note: Although nonspecific, these findings may be associated with celiac diease.

Part 2: Gastric biospies:

Fragments of gastric fundic and antral muscosa with chronic inflammation along with areas of regenerative/reactive glandular atypia.

Note: No organisms suggestive of H. pylori seen on Alcian yellow stain.

Part 3: Esophageal biospies:

Fragments of esophageal squamous mucosa with basal layer hyperplasia and slight subacute and moderate chronic inflammation.

Note: No obvious intestinal metaplasia seen on H E or Alcian blue stains. There are between 5 and 10 eosinophils per selected high power field. Clinical and endoscopic correlation recommended for evalutaion of eosinophilic esophagitis.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Takala Enthusiast
Takala
Posted

Well.... you may not be walking like a duck, but your gut is quacking like one.... welcome to the forum, never officially diagnosed division. B)

IrishHeart Veteran
IrishHeart
Posted

Since increased intraepithelial lymphocytes are associated with early stage celiac (marsh 1, for example)

AND villous blunting is certainly a celiac symptom

AND you have chronic inflammation

AND you already had a POSITIVE biopsy (geesh, how many biopsies are they going to put you through?? :blink: )

it sure would make me think I have Celiac.

MANY people have NEGATIVE blood work and positive biopsies. What's your doc's problem here????? :rolleyes:

As TAKALA says, if it walks like a duck and quacks like a duck..... :)

psawyer Proficient
psawyer
Posted

Short answer: You have Celiac Disease.

maramelia Newbie
maramelia
Posted

Hi I had a endoscopy on 12/21 and I got the results on Friday. I have had one positive and one negative biospy in the past year and neg bloodwork. These results I think are another positive. I was just looking for someone elses input as I think I have celiac and I really wish my doc would see it too, but since my bloodwork is negative he doesnt want to see it.

Part 1:Duodenal Biospies:

Fragments of duodenal mucosa with areas of villious blunting, intraepithelial lymphocytes, along with acute and chronic duodenitis.

Note: Although nonspecific, these findings may be associated with celiac diease.

Part 2: Gastric biospies:

Fragments of gastric fundic and antral muscosa with chronic inflammation along with areas of regenerative/reactive glandular atypia.

Note: No organisms suggestive of H. pylori seen on Alcian yellow stain.

Part 3: Esophageal biospies:

Fragments of esophageal squamous mucosa with basal layer hyperplasia and slight subacute and moderate chronic inflammation.

Note: No obvious intestinal metaplasia seen on H E or Alcian blue stains. There are between 5 and 10 eosinophils per selected high power field. Clinical and endoscopic correlation recommended for evalutaion of eosinophilic esophagitis.

Hi TJ.

Usually, in the AP report, the most important part i that of the duodenal biopsy --- and usually the doctors / pathologists describe those duodenal biopsies with more exactly numbers, to better understand if you have or not an enteropathy: "areas of villious blunting" - usually they write if the ratio vili/cripts is 3:1, 2:1, or less than this, or more than this... "intraepithelial lymphocytes" - usually the normal rate is 20-25 per 100 epithelial cells, depending on your age, its better to describe the number of intraepithelial lynphocytes that were finded... Did you get?

If you read some of those numbers on your report, fell free to tell me!!! With that information, it is better to grade the stage of your disease. But im sure that you may have some pathological signs (remember - they all are not specific) of celiac disease - the duodenitis, the vili blunting, and, depending on the number of intraepithelial lynphocytes, also inflamatory intracellular reaction - changes.

rgds mara

TJ060306 Apprentice
TJ060306
Posted
  • Author

Hi all!

Thanks for the responses but the doctor decied since this is the second positve in a year that it 'must' celiac! So he said to try a gluten free diet! woooo whoo!!! thanks it has been a long 2 years!

IrishHeart Veteran
IrishHeart
Posted

So glad he saw it "our" way :lol:

(Geesh, the 1st one should have been enough)

Welcome to the club! Enjoy your new healthy life OFF gluten!

Best wishes!!

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


domesticactivist Collaborator
domesticactivist
Posted

Congrats on your diagnosis. Sounds like it was a long time coming! Now the good part... Getting healthy :)

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      129,935
    • Most Online (within 30 mins)
      7,748
    Chrissie0212
    Newest Member
    Chrissie0212
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.3k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • trents
      Virus, celiac disease or both?

      By trents · Posted

      Early guidelines from years ago concerning D3 supplementation was unduly conservative. There was fear of toxicity in over-supplementing because D3 is a fat soluble vitamin and not a water soluble vitamin. More recent studies have shown we can supplement safely at considerably higher levels for extended periods. But yes, 50,000 IU would not be safe over an extended period of time. That much is a kick start dose.
    • Shining My Light
      Virus, celiac disease or both?

      By Shining My Light · Posted

      @knitty kitty I had an injury from assuming I could do work outs at the gym like I did in my 20s 😏. it didn’t work in my favor. My orthopedic doctor told me to go on 50,000IU /per week for 4-6 weeks for a boost and then do a maintenance. I took 2 and got nervous to take any more, it seemed so high to me. About 7  months later I had a blood test revealing that my Vit D levels are lower than normal. I started taking vit D supplements-4000IU./a day now. (the natural garden of life ones) I had a friend whose levels were low and she was having a mental breakdown.  My B12 levels were right in the middle of the range.     
    • knitty kitty
      Confused About Results

      By knitty kitty · Posted

      @Ginger38, Have you been checked for nutritional deficiencies, besides iron?   Celiac disease causes inflammation which results in nutritional deficiencies.   Iron needs Thiamine and the other B vitamins to make new red blood cells.   Iodine and thiamine deficiencies affect the thyroid.  The thyroid is one organ that uses lots of thiamine.   Vitamin D deficiency leads to hormonal problems, including menstrual problems.  Vitamin D needs Thiamine to activate it.   Heart palpitations and chest pain after gluten exposure can be evidence of poor digestion and a drop in available thiamine.  Consumption of any  foods high in carbohydrates can cause a drop in thiamine.  This is called high calorie malnutrition. Anxiety, numbness, tingling, acne, and brain fog are symptoms of Thiamine and the other B vitamin deficiencies.  There's eight B vitamins that all work together in concert.  They are water soluble.  They can be hard to absorb by inflamed intestines.  Vitamin A can improve acne. I suffered from all the same symptoms which only resolved with B Complex and Thiamine (in the forms TTFD and Benfotiamine) supplements, Vitamins D, A and C.  Magnesium, Thiamine and B6 Pyridoxine will get rid of the nightmares. Replenishing your vitamin and mineral stores will help heal and feel better faster.  Talk to your nutritionist and doctor about supplementing. Think about adopting the Autoimmune Protocol diet to help with SIBO and MCAS to reduce bloating and heal the intestines. @Alibu and I were just discussing diagnosis without obvious villus damage here.   This study followed people who showed no or little villi damage at first....they accrued more damage over time. Outcomes of Seropositive Patients with Marsh 1 Histology in Clinical Practice https://pmc.ncbi.nlm.nih.gov/articles/PMC4980207/ There's a move to be less reliant on endoscopy for diagnosis. Biopsy‐Sparing Diagnosis of Coeliac Disease Based on Endomysial Antibody Testing and Clinical Risk Assessment https://pmc.ncbi.nlm.nih.gov/articles/PMC12074562/
    • Ginger38
      Confused About Results

      By Ginger38 · Posted

      Okay, Thank you!! I already have thyroid problems and my total iron binding capacity is high which usually means low iron but everything else was normal, lower end but “normal” my hair falls out and my nails won’t grow without breaking but nothing is being treated iron wise.  I have started having palpitations and chest pain,  both of which seem to be attributed to exposure to gluten. I’ve also been having a lot of nightmares, anxiety, numbness and tingling, brain fog, spotting between cycles and acne. Idk if all those are relatable to gluten / celiac but I’m concerned  I’ve finally tipped my body/ immune system into a bad place. Is there anyway to detox and heal faster or treat these symptoms if related to gluten ? 
    • knitty kitty
      Waiting on biopsy after positive bloodwork, but also not really believing this is real

      By knitty kitty · Posted

      @Alibu, Start with this study... High-dose thiamine supplementation improves glucose tolerance in hyperglycemic individuals: a randomized, double-blind cross-over trial https://pubmed.ncbi.nlm.nih.gov/23715873/ "Conclusion/interpretation: Supplementation with high-dose thiamine may prevent deterioration in fasting glucose and insulin, and improve glucose tolerance in patients with hyperglycemia. High-dose thiamine supplementation may prevent or slow the progression of hyperglycemia toward diabetes mellitus in individuals with impaired glucose regulation." They used 100 mg of thiamine three times a day.  They don't say which kind of thiamine was used.  Benfotiamine is my recommendation because it has been shown to promote intestinal health and helps with leaky gut and SIBO.  Thiamine forms including Benfotiamine and TTFD are safe and nontoxic even in higher doses.   The old "gold standard" diagnosis is changing.  It must be confusing for doctors as well.  I went through all this myself, so I understand the frustration of the vagueness, but set your course and watch as your health improves. Keep us posted on your progress!   P.S. here's another link.... https://pubmed.ncbi.nlm.nih.gov/39642136/
×
×
  • Create New...