Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Genetic Hla Question

whitefairy30

Recommended Posts

whitefairy30 Rookie
whitefairy30
Posted

Hi all. I'm new to this forum. 

 

I have a genetic HLA test done. 

 

I carry the gene DBQ1*0201.

Reading over internet I found that is a gene that predispose to celiacs disease.  Doctor said NO because I have only this gene, but not the alfa chain. 

 

I'm not sure that gluten isn't a problem for me because I had for decades so many symptoms celiac related: diarrhea, constipation, extreme bloating after eat, abdominal pain, eczema, chronic sinusitis, intollerance at yeasts (tested anti asca igg weak positive but iga negative). I have fear to have crohn's because of positive anti asca but doc said I don't have crohns (my blood test was ok and the ultrasound of the ileum was ok; I don't had a colonoscopy). 

 

In 2011 I had a positive lactose intollerance test but was negative for TTG test for celiacs. 

 

In 2013 I had 2 bad flare up with diarreha and positive calprotectin. I cut off all gluten, I only eat 2 slices of spelt bread at day. I began a paleo like diet and improved a lot.

 

Last months I done a stool test, that came out positive for anti gliadin iga at 51. For curiosity I done a blood test for iga and igg anti gliadin but came out negative. 

 

With my genetics can I have gluten sensitivity? 

The negative blood test can be because I eat only a little gluten ? 

 

Should try a gluten free total diet ? 

 

Thanks. 

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Gemini Experienced
Gemini
Posted

Well.....your doctor is wrong...that is a Celiac gene and one that can present with more severe cases of it.  :rolleyes:

 

Stool testing is not valid for diagnosing Celiac Disease.  Sorry, but it is not recognized by any Celiac expert or organization.  Many people test negative on the blood testing and then have positive biopsies so having a negative test does not rule the disease out.  Is it possible to have a complete Celiac panel done?  If not, then a strict dietary trial would be helpful to see if your symptoms go away.  But you definitely have the genetics for developing Celiac Disease.

whitefairy30 Rookie
whitefairy30
Posted
  • Author

Thanks Gemini.

 

I begin a gluten-free diet now ! 

 

Maybe I'm not celiac but if I had the gene I will be careful. 

Gemini Experienced
Gemini
Posted

It's OK to go gluten free without a positive diagnosis BUT it's a committment so.....NO CHEATING!  ;)

 

You actually do not know if you really do have Celiac or not but if you have the genetics to trigger for it, and you do, I would be serious about following the diet.  With your history and gene testing results, there is a good chance you do.  Good luck with the diet and let us know how it goes!

whitefairy30 Rookie
whitefairy30
Posted
  • Author

Thanks !!

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      132,918
    • Most Online (within 30 mins)
      7,748
    Dizzyma
    Newest Member
    Dizzyma
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • xxnonamexx
      Fermented foods, Kefir, Kombucha?

      By xxnonamexx · Posted

      very interesting thanks for the info  
    • Florence Lillian
      gluten free cookie recipes

      By Florence Lillian · Posted

      More cookie recipes ...thanks so much for the heads-up Scott.  One can never have too many.  Cheers, Florence.
    • Russ H
      Severe severe mouth pain

      By Russ H · Posted

      Hi Charlie, You sound like you have been having a rough time of it. Coeliac disease can cause a multitude of skin, mouth and throat problems. Mouth ulcers and enamel defects are well known but other oral conditions are also more common in people with coeliac disease: burning tongue, inflamed and swollen tongue, difficulty swallowing, redness and crusting in the mouth corners, and dry mouth to name but some. The link below is for paediatric dentistry but it applies to adults too.  Have you had follow up for you coeliac disease to check that your anti-tTG2 antibodies levels have come down? Are you certain that you not being exposed to significant amounts of gluten? Are you taking a PPI for your Barrett's oesophagus? Signs of changes to the tongue can be caused by nutritional deficiencies, particularly iron, B12 and B9 (folate) deficiency. I would make sure to take a good quality multivitamin every day and make sure to take it with vitamin C containing food - orange juice, broccoli, cabbage etc.  Sebaceous hyperplasia is common in older men and I can't find a link to coeliac disease.   Russ.   Oral Manifestations in Pediatric Patients with Coeliac Disease – A Review Article
    • cristiana
      Severe severe mouth pain

      By cristiana · Posted

      Hi @Charlie1946 You are very welcome.   I agree wholeheartedly with @knitty kitty:  "I wish doctors would check for nutritional deficiencies and gastrointestinal issues before prescribing antidepressants." I had a type of tingling/sometimes pain in my cheek about 2 years after my diagnosis.  I noticed it after standing in cold wind, affecting  me after the event - for example, the evening after standing outside, I would feel either tingling or stabbing pain in my cheek.   I found using a neck roll seemed to help, reducing caffeine, making sure I was well-hydrated, taking B12 and C vitamins and magnesium.  Then when the lockdowns came and I was using a facemask I realised that this pain was almost entirely eliminated by keeping the wind off my face.  I think looking back I was suffering from a type of nerve pain/damage.  At the time read that coeliacs can suffer from nerve damage caused by nutritional deficiencies and inflammation, and there was hope that as bodywide healing took place, following the adoption of a strict gluten free diet and addressing nutritional deficiencies, recovery was possible.   During this time, I used to spend a lot of time outdoors with my then young children, who would be playing in the park, and I'd be sheltering my face with an upturned coat collar, trying to stay our of the cold wind!  It was during this time a number of people with a condition called Trigeminal Neuralgia came up to me and introduced themselves, which looking back was nothing short of miraculous as I live in a pretty sparsely populated rural community and it is quite a rare condition.   I met a number of non-coeliacs who had suffered with this issue  and all bar one found relief in taking medication like amitriptyline which are type of tricyclic anti-depressant.   They were not depressed, here their doctors had prescribed the drugs as pain killers to address nerve pain, hence I mention here.  Nerve pain caused by shingles is often treated with this type of medication in the UK too, so it is definitely worth bearing in mind if standard pain killers like aspirin aren't working. PS  How to make a neck roll with a towel: https://www.painreliefwellness.com.au/2017/10/18/cervical-neck-roll/#:~:text=1.,Very simple. 
    • Scott Adams
      gluten free cookie recipes

      By Scott Adams · Posted

      We just added a ton of new recipes here: https://www.celiac.com/celiac-disease/gluten-free-recipes/gluten-free-dessert-recipes-pastries-cakes-cookies-etc/gluten-free-cookie-recipes/
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.