Question about anti DGP and other tests

[Frankie13]

Hey, how are you fellows, I have many questions about my situation, I hope someone could help me or give some advice.

First i am not yet diagnosed fully, I receive a lot of opinions that is all in my head, no one in my family hace celiac, etc, I decide by myself going to an almost strict and I feel fine the diarrheas, and headaches dissappear the tiredness and stomach noises sometimes comes maybe because i think i could no fully control the things I eat, Im worried about having some weight loss but I think is because the few things that have no gluten and I dont eat as I do before i get these problems but I have to be sure I am celiac.

I had serological tests and come positive EMA and Anti gliadin, then i had a biopsy which only showed chronic inflammation in the bowel but no signs of Marsh 1, 2 or 3, the doctor says is normal the inflamation and that all people could have that, he told me to do again blood tests in another laboratory, every time i eat gluten I get sick of flu and very intense so after 3 weeks of eating again gluten i did the blood tests (i was very sick of flu, I dont know if this could affect), and the results showed all normal (EMA and antigliadin normal) but I had very low in the limit betacarotene 0.1 (0.08 . 0.80 is the range) and it showed this:

*The test detects antibodies to deaminated gliadin peptide IGG and IGA

But no values :/ Im tired of not knowing what do I have, if someone could help me interpreting this i would appreciate it so much.

 

 

 

[ironictruth]

You should be on gluten for 3 months for bloodwork. 

 

It sounds  like Celiac  or a gluten sensitivity if your previous blood work was positive. Did you get the genetic test? You do not have to be eating gluten for the gene test. you could have the gene in the family and no one has developed it but perhaps you have.

[Gemini]

Frankie.......The original testing that showed a positive EMA and anti gliadin are pretty definitive for Celiac Disease. No other disease but Celiac will give you a positive on the EMA.  However, because the doctors failed to find villous atrophy on your biopsy, they will not give you a Celiac diagnosis.  Just because the biopsy was negative does not mean you do not have Celiac Disease.  They may have missed the spots that had damage and that is very common.  The small intestine has a lot of surface area so it can be easily missed.

On the second testing you had that showed elevated Deamidated gliadin peptides, you are reacting to the gluten in your diet.  This is the test they repeat to see if you are compliant with the diet so numbers will go up and down, depending on how much gluten you are eating. This is why you have to be eating gluten for about 3 months to be tested. So, you are reacting to gluten.

You have a couple of choices here. You can either make yourself sick and hope you can last 3 months eating gluten every day so you can re-test or you can go strictly gluten free and see how well you do on the diet.  I don't know what country you live in but I know it can be difficult to have repeat testing done.  With these test results and your admission that you felt better and had some symptoms resolve on the diet, I think you know you may have Celiac Disease.  You cannot have diarrhea for long, and weight loss, before you get very sick. I was also extremely sick when diagnosed so know how you feel.  If you decide to go ahead with the diet, its very, very important that you do not cheat....at all.  Otherwise, you may have to find another doctor to help you to be tested correctly.  I would say that you most likely have Celiac, with what you have posted here.  Just having a gluten sensitivity will not elevate blood work.

I wish you luck and if you have any questions, just ask!  

[firefly42]

I'd say you have celiac with the positive blood work. My sons biopsy had half a page written up for each piece they biopsied, but the lab said that the changes weren't indicative of celiac. All of his blood work was positive and his dr officially diagnosed celiac regardless of the biopsy and what do you know since gluten free he's doing so much better.