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Info Needed On Total Iga


jonical

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jonical Newbie

I have just received results of my son's celiac serology. I am confused and as it took 2 weeks to get a "preliminary report" from his doc, I am not hopeful to get a quick answer to my questions on how to interpret the results. I am hoping someone can help. Results I was given are:

AGA IgG+

AGA IgA-

TTG IgA-

EMA IgA-

TOTAL IgA 113 mg/dl

My son is 14. In searching the web, I am concluding that celiac disease is not likely with these results, but I do not know what a normal Total IgA should be. Can someone inform me?


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happygirl Collaborator

What is the reference range for the total IgA from the bloodwork?

jonical Newbie
What is the reference range for the total IgA from the bloodwork?

I do not know. I have not been successful in obtaining a copy of the actual report from the lab. All I can get from his Doc is a Preliminary Report with the results as I posted... no values to determine what a normal range is. Just that: Total IgA 113 mg/dl

ShayFL Enthusiast

From EVERY reference range I have seen for total IgA that is either rock bottom or down right deficient. What this means is that he will NEVER get a positive antibody with IgA (even if he is so severely Celiac that he develops lymphoma) because his body simply does not product much of that antibody. When this happens astute doctors then test IgG. Which has already been done and it is POS.

Will he have a biopsy?

Or a trial of the diet? The diet is really the ONLY true measuring stick.

You could also opt for genetic testing as just one more check mark to make you feel comfortable going gluten-free.

April in KC Apprentice

There are low or deficient IGA celiacs. If you end up finding that your ref. range indicates that's on the low side, then take this to your doctor...

Open Original Shared Link

It explains some other tests (IGG versions of the TTG and EMA tests) that can be run for your son. I don't know if all labs offer those versions of the tests, though...most Celiac panels include the IGA version of the TTG and EMA.

Best wishes!

bizzymomof5 Newbie

My husband just picked up my daughters lab results from the doctor. They were not real confident in interpreting the results. They have referred us to a pediatric doctor with the results. That appt. is next week. However, in looking at her results it says that the range for IGA is 53-204 mg/dL. That is the only figure I see with the mg/dL after the numbers. The sheet has a column for Low, Normal, High, Flag, and Reference. The figure I gave you is from the reference column. So I guess that means that's your reference point and that anything from 53-204 would be within normal range. Of course, I'm not a doctor either. :-)

bizzymomof5

I do not know. I have not been successful in obtaining a copy of the actual report from the lab. All I can get from his Doc is a Preliminary Report with the results as I posted... no values to determine what a normal range is. Just that: Total IgA 113 mg/dl
fedora Enthusiast

Diffferent labs have different reference ranges. You need to find out the range from the lab you used.

Also remember , the blood tests are no always accurate.


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happygirl Collaborator

Based on the blood work, it does not appear that your son is IgA deficient, which makes other IgA testing more accurate.

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    • par18
      Thanks for the reply. 
    • Scott Adams
      What you’re describing is actually very common, and unfortunately the timing of the biopsy likely explains the confusion. Yes, it is absolutely possible for the small intestine to heal enough in three months on a strict gluten-free diet to produce a normal or near-normal biopsy, especially when damage was mild to begin with. In contrast, celiac antibodies can stay elevated for many months or even years after gluten removal, so persistently high antibody levels alongside the celiac genes and clear nutrient deficiencies strongly point to celiac disease, even if you don’t feel symptoms. Many people with celiac are asymptomatic but still develop iron and vitamin deficiencies and silent intestinal damage. The lack of immediate symptoms makes it harder emotionally, but it doesn’t mean gluten isn’t harming you. Most specialists would consider this a case of celiac disease with a false-negative biopsy due to early healing rather than “something else,” and staying consistently gluten-free is what protects you long-term—even when your body doesn’t protest right away.
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