Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Test Results

e&j0304

Recommended Posts

e&j0304 Enthusiast
e&j0304
Posted

Here are some test results of a family member. What do you think?

IgA, quant, Serum 468 reference 70-400

Gliadin IgG 5.7 <=25

Gliadin IgA 66.7 <=25

Tiss. Transglutaminase, IgA 2.5 <7 negative

So the ones in bold were marked as high. I realize that the neg. ttg indicates no celiac. Does the IgA mean anything? I remember hearing that it is not specific to celiac. Why is it part of a celiac panel if it isn't? This person suffers from several things and could likely be gluten intolerant. I believe they might try the diet sometime soon.

Just looking for some insight!

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


e&j0304 Enthusiast
e&j0304
Posted
  • Author

Ok, I just found this information on the American Celiac Disease Alliance website (Open Original Shared Link)

The antigliadin antibodies IgG and IgA recognize a small piece of the gluten protein called gliadin. These antibodies became available during the late 1970

e&j0304 Enthusiast
e&j0304
Posted
  • Author

ANYONE?

e&j0304 Enthusiast
e&j0304
Posted
  • Author

Ok, this is the last time I will bother all of you with a question. Is there anyone out there who knows if an elevated IgA means anything if the rest of the panel is negative? I am going to ask a ped. GI next week when we go for my son but kind of hoped that of the 58 people who have viewed this thread maybe one could answer.

jayhawkmom Enthusiast
jayhawkmom
Posted

Yes, it means that the person is reacting to gluten. But, it doesn't mean that they are reacting because of Celiac Disease. It could be gluten intolerance or other "leaky gut" issues.

IgG is more sensitive, but less specific.

IgA is less sensitive, but more specific.

The total syrum IgA is elevated, and I have absolutely NO idea what that means at all. But, the IgA antigliadin could be elevated due to the elevation of the total syrum IgA.

Jestgar Rising Star
Jestgar
Posted
kind of hoped that of the 58 people who have viewed this thread maybe one could answer.

It's all just a plot. We only view- not answer..

Seriously, though-

Do you mean the total IgA?

I don't have an answer, but someone who does might need the clarification.

chrissy Collaborator
chrissy
Posted

i don't think that the raised total IgA serum is particularly significant and the antigliadin IgA could be raised by things other than celiac. it would probably be a good idea to do further investigating.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


happygirl Collaborator
happygirl
Posted

generally, the total IgA number is important if it is low, which means that you can have trouble scoring positive on other tests, even if you actually are positive.

the absence of tTG doesn't mean 100% that you don't have Celiac. Higher levels of intestinal damage are correlated with tTG, so you could be mildly damaged, and not scoring positive (yet).

The doctor did not run another important test, which is the EMA IgA (see full panel: Open Original Shared Link

Further----taken from the above mentioned website:

"Seronegative celiac disease

Both the anti-tTG and the EMA titers correlate with the severity of villous atrophy [26-29]. As a result in the presence of partial villous atrophy either antibody may be negative. In addition the mode of presentation of the celiac disease, i.e. presence of silent or subclinical celiac disease may be associated with a negative EMA [30]. Clinically seronegative celiac disease is similar to sero-positive celiac disease [23, 28] In view of the possibility of the presence of celiac disease in the absence of a positive anti-tTG or endomysial antibody the presence of a positive IgA AGA should prompt a biopsy [13]. Several studies have demonstrated that reliance on either anti-tTG or endomysial antibody as a single test will underestimate the prevalence of celiac disease [23, 25, 31, 32]. "

The fact that this person is having symptoms, and shows some sort of reaction (whether its Celiac/nonCeliac is up in the air), indicates that trying the gluten-free diet would certainly be an important option, esp if other tests are not shedding any light. (My doctor only ran the IgG and IgA, didn't run the others---I knew nothing about Celiac----it was positive, and going gluten free changed my life).

Hope this helps.

e&j0304 Enthusiast
e&j0304
Posted
  • Author

Thank you all so much for responding and for your advice/knowledge about this. His Total IgA was high, but I was actually wondering about his anti-gliadin IgA which was also quite elevated.

Chrissy, do you know off had which other conditions could cause an elevated IgA? I have been looking all day and can only find things that cause an elevated IgG (crohn's etc). I really didn't find much about the IgA other than that it was specific for celiac. Nothing I read touched on if it means anything when paired with other tests that are normal.

Thanks again. We are going to see a pediatric GI next week for my son who suffers from reflux so we'll ask him them.

PS Jestgar: I KNEW it was a all just a plot against me... :P

Jaynee Newbie
Jaynee
Posted

I am not sure I get this . I had the Ttg test and the result came back negative at 7.1. It said anything less than 20 was negative. But I have read on here that some people say anything less than 7 is negative. I am confused.

Example someone said this,

Tiss. Transglutaminase, IgA 2.5 <7 negative

My lab results say <20 is negative.

Help.

Thanks.

happygirl Collaborator
happygirl
Posted

Jaynee:

Lab results vary per lab. That is why they list the reference ranges, because what is positive on one, is not on another. So, it depends on which lab was used and their methods (this applies to many other tests, not just Celiac).

Hope that clears up the confusion!

Laura

  • 3 months later...
Judee Newbie
Judee
Posted

What ever came of your child's high Gliadin IgA test , high total IgA serum, with negative IgG and negative TtG.

My son has similar blood work (high Gliadin IgA, but no idea on the total IgA serum number, negative on the other tests) and I can not make sense of it.

Judee

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      133,048
    • Most Online (within 30 mins)
      7,748
    Delpickle1
    Newest Member
    Delpickle1
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • tiffanygosci
      Celiac support is hard to find

      By tiffanygosci · Posted

      Hi Cristiana! It's so nice to meet you! Thank you for the kind reply I am glad I live in a time where you can connect with others through the Internet. That is a mercy I am grateful for.
    • knitty kitty
      Positive biopsy

      By knitty kitty · Posted

      In the study linked above, the little girl switched to a gluten free diet and gained enough weight that that fat pad was replenished and surgery was not needed.   Here's the full article link... Superior Mesenteric Artery Syndrome in a 6-Year-Old Girl with Final Diagnosis of Celiac Disease https://pmc.ncbi.nlm.nih.gov/articles/PMC6476019/
    • knitty kitty
      Fruits & Veggies

      By knitty kitty · Posted

      Hello, @Jordan Carlson, So glad you're feeling better.   Tecta is a proton pump inhibitor.  PPI's also interfere with the production of the intrinsic factor needed to absorb Vitamin B12.  Increasing the amount of B12 you supplement has helped overcome the lack of intrinsic factor needed to absorb B12. Proton pump inhibitors also reduce the production of digestive juices (stomach acids).  This results in foods not being digested thoroughly.  If foods are not digested sufficiently, the vitamins and other nutrients aren't released from the food, and the body cannot absorb them.  This sets up a vicious cycle. Acid reflux and Gerd are actually symptoms of producing too little stomach acid.  Insufficient stomach acid production is seen with Thiamine and Niacin deficiencies.  PPI's like Tecta also block the transporters that pull Thiamine into cells, preventing absorption of thiamine.  Other symptoms of Thiamine deficiency are difficulty swallowing, gagging, problems with food texture, dysphagia. Other symptoms of Thiamine deficiency are symptoms of ADHD and anxiety.  Vyvanse also blocks thiamine transporters contributing further to Thiamine deficiency.  Pristiq has been shown to work better if thiamine is supplemented at the same time because thiamine is needed to make serotonin.  Doctors don't recognize anxiety and depression and adult onset ADHD as early symptoms of Thiamine deficiency. Stomach acid is needed to digest Vitamin C (ascorbic acid) in fruits and vegetables.  Ascorbic acid left undigested can cause intestinal upsets, anxiety, and heart palpitations.   Yes, a child can be born with nutritional deficiencies if the parents were deficient.  Parents who are thiamine deficient have offspring with fewer thiamine transporters on cell surfaces, making thiamine deficiency easier to develop in the children.  A person can struggle along for years with subclinical vitamin deficiencies.  Been here, done this.  Please consider supplementing with Thiamine in the form TTFD (tetrahydrofurfuryl disulfide) which helps immensely with dysphagia and neurological symptoms like anxiety, depression, and ADHD symptoms.  Benfotiamine helps with improving intestinal health.  A B Complex and NeuroMag (a magnesium supplement), and Vitamin D are needed also.
    • knitty kitty
      Positive biopsy

      By knitty kitty · Posted

      @pothosqueen, Welcome to the tribe! You'll want to get checked for nutritional deficiencies and start on supplementation of B vitamins, especially Thiamine Vitamin B 1.   There's some scientific evidence that the fat pad that buffers the aorta which disappears in SMA is caused by deficiency in Thiamine.   In Thiamine deficiency, the body burns its stored fat as a source of fuel.  That fat pad between the aorta and digestive system gets used as fuel, too. Ask for an Erythrocyte Transketolace Activity test to look for thiamine deficiency.  Correction of thiamine deficiency can help restore that fat pad.   Best wishes for your recovery!   Interesting Reading: Superior Mesenteric Artery Syndrome in a 6-Year-Old Girl with Final Diagnosis of Celiac Disease https://pubmed.ncbi.nlm.nih.gov/31089433/#:~:text=Affiliations,tissue and results in SMAS.  
    • trents
      Positive biopsy

      By trents · Posted

      Wow! You're pretty young to have a diagnosis of SMA syndrome. But youth also has its advantages when it comes to healing, without a doubt. You might be surprised to find out how your health improves and how much better you feel once you eliminate gluten from your diet. Celiac disease is an autoimmune disorder that, when gluten is consumed, triggers an attack on the villous lining of the small bowel. This is the section of the intestines where all our nutrition is absorbed. It is made up of billions of tiny finger-like projections that create a tremendous surface area for absorbing nutrients. For the person with celiac disease, unchecked gluten consumption generates inflammation that wears down these fingers and, over time, greatly reduces the nutrient absorbing efficiency of the small bowel lining. This can generate a whole host of other nutrient deficiency related medical problems. We also now know that the autoimmune reaction to gluten is not necessarily limited to the lining of the small bowel such that celiac disease can damage other body systems and organs such as the liver and the joints and cause neurological problems.  It can take around two years for the villous lining to completely heal but most people start feeling better well before then. It's also important to realize that celiac disease can cause intolerance to some other foods whose protein structures are similar to gluten. Chief among them are dairy and oats but also eggs, corn and soy. Just keep that in mind.
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.