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Study Finds Gut Bacteria can Affect Intestines' Protective Layer - Celiac.com

Scott Adams

By Scott Adams
in Publications & Publicity

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Scott Adams Grand Master
Scott Adams
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Celiac.com

Study Finds Gut Bacteria can Affect Intestines' Protective Layer

Celiac.com

She blogs about intestinal health at: Open Original Shared Link New research could lead to treatment for celiac disease. Celiac.com 03/15/2011 - For celiacs, it's not really the cinnamon bun that's the enemy. Nor the pizza crust, ...

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    • trents
      Should I ask for more testing? Celiac vs. Gluten Sensitivity

      By trents · Posted

      Welcome to the forum, @Natosha! For future reference, when you share celiac blood antibody test scores, it is helpful to also include reference ranges for negative vs. positive since there are no industry standards in place. Each lab uses different scales. But, you have told us the results of the testing were negative, so we have the big picture. Looks like you had two tests run: tTG-IGA and DGP-IGA. One that should have been run and wasn't is "total IGA" which goes by some other names as well. Total IGA is important to run because it checks for IGA deficiency. If a person is IGA deficient, their individual IGA celiac antibody test scores will be artificially low and false negatives can be generated. Some doctors are under the mistaken impression that IGA deficiency only occurs in toddlers but we have had any number of adult contributors on this forum who were IGA deficient. I bring this up as you might ask that your PCP test you for IGA deficiency. No, three days of being gluten free would not likely have much impact on your test scores. I am also assuming that prior to that, you were eating liberal amounts of wheat products and not skimping on them because you suspected they made you ill. If you don't have celiac disease you may very well have NCGS (Non Celiac Gluten Sensitivity). NCGS shares many of the same symptoms of celiac disease but does not damage the lining of the small bowel as does celiac disease. There is no test for it. A diagnosis for NCGS depends on first ruling out celiac disease. It is 10x more common than celiac disease. Some experts feel it can be a precursor to the development of celiac disease. Eliminating gluten from your life is the antidote for both. I am including an article that discusses the various antibody tests that can be run for celiac disease detection. Your doc only ordered two. As you can see, there are several others. One one misses, another may catch. Some are more sensitive than others or are more specific. You could ask your doc for a "full celiac panel". For reference, you would need to be eating an amount of gluten daily for several weeks equivalent to what would be found in 4-6 slices of wheat bread leading up to the day of the blood draw or the testing to be valid. This is what current "gluten challenge" guidelines are recommending. By, the way, your doctor referring to starting the gluten free diet to address gluten sensitivity as a "fad" is not a good sign. That's a bad attitude and probably reflects outdated knowledge concerning gluten disorders. I think I would be shopping for another doc.
    • trents
      Should I ask for more testing? Celiac vs. Gluten Sensitivity

      By trents · Posted

      Welcome to the forum, @Natosha! For future reference, when you share celiac blood antibody test scores, it is helpful to also include reference ranges for negative vs. positive since there are no industry standards in place. Each lab uses different scales. But, you have told us the results of the testing were negative, so we have the big picture. Looks like you had two tests run: tTG-IGA and DGP-IGA. One that should have been run and wasn't is "total IGA" which goes by some other names as well. Total IGA is important to run because it checks for IGA deficiency. If a person is IGA deficient, their individual IGA celiac antibody test scores will be artificially low and false negatives can be generated. Some doctors are under the mistaken impression that IGA deficiency only occurs in toddlers but we have had any number of adult contributors on this forum who were IGA deficient. I bring this up as you might ask that your PCP test you for IGA deficiency. No, three days of being gluten free would not likely have much impact on your test scores. I am also assuming that prior to that, you were eating liberal amounts of wheat products and not skimping on them because you suspected they made you ill. If you don't have celiac disease you may very well have NCGS (Non Celiac Gluten Sensitivity. NCGS shares many of the same symptoms of celiac disease but does not damage the lining of the small bowel as does celiac disease. There is no test for it. A diagnosis for NCGS depends on first ruling out celiac disease. It is 10x more common than celiac disease. Some experts feel it can be a precursor to the development of celiac disease. Eliminating gluten from your life is the antidote for both. I am including an article that discusses the various antibody tests that can be run for celiac disease detection. Your doc only ordered two. As you can see, there are several others. One one misses, another may catch. Some are more sensitive than others or are more specific. You could ask your doc for a "full celiac panel". For reference, you would need to be eating an amount of gluten daily for several weeks equivalent to what would be found in 4-6 slices of wheat bread leading up to the day of the blood draw or the testing to be valid. This is what current "gluten challenge" guidelines are recommending.  
    • Vickey Matteson
      Upset stomach

      By Vickey Matteson · Posted

      Hi, recently I've started getting nauseated different times of the day. It doesn't last too long but I can't seem to connect it with anything except maybe I'm hungry? Any ideas? Vickey
    • Natosha
      Should I ask for more testing? Celiac vs. Gluten Sensitivity

      By Natosha · Posted

      Hi! I apologize that this is going to be a long post but I am hoping to gain some insight from anyone who knows more about Celiac than I do. About 1 year ago I started have weird neurological symptoms(numbness/tingling, headaches, dizziness). This led me to a neurologist who found no issues and treated me for migraines and sent me to a hematologist. They hematologist also found no issues but asked me if I had and gastro issues ( i had been having chronic diaherra also) and if I had ever been tested for gluten sensitivity or Celiac disease as alot of my symptoms could be related to issues with gluten. This got me thinking about my 23 and me results that stated I was at a higher risk for developing Celiac ( I had never put much thought into before hand). I started doing a bit more research. I am a carrier of the HLA-DQ8 gene and I have also been a Type 1 diabetic for 14 years. I started eating gluten free right away hoping it would resolve my symptoms and begged my PCP for a celiac panel. I didn't realize that I should have stayed on gluten until the test was done. So I had been eating gluten free for about 3 days before my celiac panel, I did eat a gluten filled breakfast the morning of my blood test. My test results were, TISSUE TRANSGLUTAMINASE ANTIBODIES IGA QUANTITATIVE of <0.5 u/ml and GLIADIN (DEAMIDATED) ANTIBODY IGA QUANTITATIVE of 3.0 u/ml. My PCP told me my results were negative. I asked if he felt I had a gluten sensitivity and he told me that that was more of a "fad" diet and that I could go gluten free if I wanted to. I haven't had gluten in a year but I don't worry too much about cross contamination. I have eaten a few things that have made me very nauseous, bloated, caused diaherra, and vomiting but I'm not sure if it was from gluten or something else. I guess my questions are: do you think that the 3 days of no gluten messed with test results? , should I ask for more testing and if so what?, and would gluten sensitivity cause the same issues as Celiac? Thanks so much!
    • Wheatwacked
      Muscle atrophy in legs

      By Wheatwacked · Posted

      Thanks for bringing this up again.    That week my doctor sent me for a Carotid Artery scan that came back 90% blockage on both sides.  Short story I had a stent put in right carotid artery. Just now getting back to normal from the Anesthesia. Surgery healed well, but it took until the next day to wake up from the anesthesia. A combination of time and B6.  Anesthesia depletes B6, slowing digestion and peristalsis and is also responsible for my freezing cold toes. These are my symptoms.  As a kid I had weak legs.  But now, 10 minute walk and I can barely move my legs.  I blamed it on the sedentary lifesyle from the general pain, and atrophy was to be expected. And with predisone for the pain and Gluten free I expected recovery. With the carotid artery blockage it got me to thinking it is blockage in the Ileac or Celiac arteries.  I might pursue that but the diet is the answer. I would rather not do more surgery if avoidable. Most important.  Every symptom on this list can be the result of a vitamin or mineral deficiency. Particularly B1 and B6, Iodine and choline and vitamin D. Celiac Disease is a disease of malnutrition by malabsorption or even dietary choices.  In the US the commercial bakeries stopped using iodine as a dough conditioner.  From 1970 to 1984 the average american intake of iodine went down 50%. CoQ10 may be beneficial.  It is given to people taking statins to negate the muscle myopathy caused by statins. Inclusion Body Myositis: Unknown Cause: Not Inherited: No Cure: Progressive Muscle Weakness: Asymmetrical Weakness: Distal Muscle Involvement: Swallowing Difficulties (Dysphagia): Muscle Cramps and Pain:  
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