Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Celiac Disease Vaccine Shows Promising Results in Phase I Trial - Science Daily (press release)

Scott Adams

Recommended Posts

Scott Adams Grand Master
Scott Adams
Posted

Open Original Shared Link

Science Daily (press release)

ScienceDaily (May 8, 2011) — The world's first potential vaccine for celiac disease has shown promising results for treating celiac disease in a Phase I clinical trial and is expected to move to Phase II trials within the next year. ...

Open Original Shared Link

Open Original Shared Link

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


GlutenFreeManna Rising Star
GlutenFreeManna
Posted

I'm having difficulty understanding this--how can they make a vaccine when Celiac is not caused by a virus? Also will this help those that already have active celiac or only possibly prevent it from presenting in those with the most common genes? If it works, will they withhold it from people that are not formally diagnosed? And what are the risks? I think I will stick with just eating a mostly whole food gluten-free diet instead....

AgainstTheGrainIdaho Rookie
AgainstTheGrainIdaho
Posted

I'm having difficulty understanding this--how can they make a vaccine when Celiac is not caused by a virus? Also will this help those that already have active celiac or only possibly prevent it from presenting in those with the most common genes? If it works, will they withhold it from people that are not formally diagnosed? And what are the risks? I think I will stick with just eating a mostly whole food gluten-free diet instead....

Makes you wonder huh? Kind of like the vaccine for cervical cancer? Hmmm....Who knows? I know they are trying things for diabetes too though. Weird. Don't get it. Would it really work? I guess we'll see.

ravenwoodglass Mentor
ravenwoodglass
Posted

Makes you wonder huh? Kind of like the vaccine for cervical cancer? Hmmm....Who knows? I know they are trying things for diabetes too though. Weird. Don't get it. Would it really work? I guess we'll see.

It does make one wonder. The vaccine for cervical cancer is a vaccine for the HPV virus. Or rather for a couple of the strains of the HPV as there are more than just one. It is thought that the HPV virus is a contributing factor in the development of cervical cancer. It is however not the only cause of cervical cancer and selling it as a cancer 'vaccine' is IMHO kind of dishonest use by big pharma of a scare factor to sell more of the vaccine.

Since celiac is not a virus I also wonder how they are going to develop a vaccine for it and if they do what will be the side effects. It seems to me that money would be better spent in trying to develop more sensitive tests for celiac and educational programs for doctors and the general population. It is Celiac Disease Awareness Month, or is it? I know I haven't seen any news blurbs about it.

Kate79 Apprentice
Kate79
Posted

It sounds to me to be similar to those de-sensitizing trials they do with some peanut allergy sufferers. They give the patient a minute amount of peanut, and gradually up the dosage until the body is used to it and more and more can be tolerated. With this, it sounds like they've found a way to gradually de-sensitize patients to gluten.

From the article, I wonder whether people would have to do these shots all the time? It mentions a once-weekly shot for three weeks... If that's the case, staying gluten free might be preferable! Also - it only mentions that it'll work for 90% of DQ2 people - nothing about DQ8 markers or those who are 'just' gluten intolerant.

GlutenFreeManna Rising Star
GlutenFreeManna
Posted

It sounds to me to be similar to those de-sensitizing trials they do with some peanut allergy sufferers. They give the patient a minute amount of peanut, and gradually up the dosage until the body is used to it and more and more can be tolerated. With this, it sounds like they've found a way to gradually de-sensitize patients to gluten.

From the article, I wonder whether people would have to do these shots all the time? It mentions a once-weekly shot for three weeks... If that's the case, staying gluten free might be preferable! Also - it only mentions that it'll work for 90% of DQ2 people - nothing about DQ8 markers or those who are 'just' gluten intolerant.

Not to mention that even if they successfully reintroduce gluten without negative reactions this study has no way of predicting the long term effects. Drs used to think that kids outgrew celiac disease, now they know differently and for the kids that were told they outgrew it and then later had worse symptoms the consequences to their heatth could be great if they don't realize they need to go gluten free again. IMO, eating gltuen without any short-term consequences is not worth the risk of the long term developments like cancer.

Mack the Knife Explorer
Mack the Knife
Posted

Here are some more articles about the research:

Open Original Shared Link

Open Original Shared Link

Open Original Shared Link

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Roda Rising Star
Roda
Posted

Even if it does work it wouldn't help me with my avenin sensitivity...

"In our Phase I trial, we saw a Nexvax2®-specific T-cell response that confirms the desired bioactivity in HLA-DQ2 genotype patients," Dr Anderson said. "We expect the vaccine to enter Phase II trials within the next 10 months, and hope to demonstrate a dramatic reduction in the body's rejection of dietary gluten so patients can resume a normal diet and return to good health."

I really didn't like the last sentence. Gluten free diet can in most cases return people to good health also. It also stated that it is to have a reduction in reactions. So does that mean on some level there is autoimmunity still going on? I don't miss gluten filled food that bad.

cahill Collaborator
cahill
Posted

It seems to me that money would be better spent in trying to develop more sensitive tests for celiac and educational programs for doctors and the general population. It is Celiac Disease Awareness Month, or is it? I know I haven't seen any news blurbs about it.

I agree but then there would not be any money in it for the pharmaceutical companys would there. :angry:

The treatment for celiacs is a gluten free diet,the pharmaceutical companies can not make money off of that so, IMHO, celiacs does NOT get their support(money for research,better testing ,awareness campaigns,ect... ), instead they opt for something they can make money off of ( a vaccine )instead of what is in the best interest of the general population (awareness,better testing,information )

Pac Apprentice
Pac
Posted

I really didn't like the last sentence. Gluten free diet can in most cases return people to good health also. It also stated that it is to have a reduction in reactions. So does that mean on some level there is autoimmunity still going on? I don't miss gluten filled food that bad.

I don't like the last sentence either.

As for why they are developing the vaccine, they make that quite clear on their website:

"It has been predicted that 50-60% of affected patients will be diagnosed in developed countries by 2019, creating a potential pharmaceutical market worth US$8 billion."

etta694 Explorer
etta694
Posted

"The drug triggers the death of the cells that cause the damaging immune response,'' he said. ''By doing that you switch the immune reaction from a damaging one to a tolerant one.''"

I also wonder what else this affects if cells which are a normal part of our immune response are killed. What else are these cells responsible for (long term)? Its like taking out the squeaky hinge.. and then finding out the door falls off.

Edo Rookie
Edo
Posted

I agree with those who are skeptical. The vaccine wouldn't be for me anyway because I'm not DQ2. But either way, knowing what I now know about nutrition and our food system, even if I could eat gluten and processed foods and everything else, I still wouldn't. Even if they can guarantee zero autoimmune response and no other consequences from the vaccine, that doesn't mean there aren't plenty of other health consequences to eating a "normal" diet again. I think of celiac as forcing me back to a healthy, natural human diet, and away from the food system that is making people sick, celiac or otherwise. The vaccine is just feeding into the mentality that we should be fitted to the system, instead of the system being fitted to us. It makes a lot of dollars, but not a lot of sense.

Mack the Knife Explorer
Mack the Knife
Posted

These are some of the new stories thta have appeared in Australia leading up to this latest announcement:

Mack the Knife Explorer
Mack the Knife
Posted

And these just got posted up on Youtube:

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. dixonpete
      0

      Hookworm load planner

    2. AlwaysLearning
      - AlwaysLearning replied to Colleen H's topic in Coping with Celiac Disease
      3

      Gluten related ??

      Get tested for vitamin deficiencies. Though neuropathy can be a symptom of celiac, it can also be caused by deficiencies due to poor digestion caused by celiac and could be easier to treat.
    3. Colleen H
      - Colleen H replied to Colleen H's topic in Coping with Celiac Disease
      3

      Gluten related ??

      Thank you so much for your response Yes it seems as though things get very painful as time goes on. I'm not eating gluten as far as I know. However, I'm not sure of cross contamination. My system seems to weaken to hidden spices and other possibilities. ??? if cross contamination is possible...I am in a super sensitive mode of celiac disease...
    4. Jmartes71
      - Jmartes71 replied to Jmartes71's topic in Coping with Celiac Disease
      4

      My only proof

      EXACTLY! I was asked yesterday on my LAST video call with Standford and I stated exactly yes absolutely this is why I need the name! One, get proper care, two, not get worse.Im falling apart, stressed out, in pain and just opened email from Stanford stating I was rude ect.I want that video reviewed by higher ups and see if that women still has a job or not...
    5. AlwaysLearning
      - AlwaysLearning replied to Jmartes71's topic in Coping with Celiac Disease
      4

      My only proof

      We feel your pain. It took me 20+ years of regularly going to doctors desperate for answers only to be told there was nothing wrong with me … when I was 20 pounds underweight, suffering from severe nutritional deficiencies, and in a great deal of pain. I had to figure it out for myself. If you're in the U.S., not having an official diagnosis does m...
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      132,089
    • Most Online (within 30 mins)
      7,748
    Clare Durham
    Newest Member
    Clare Durham
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • AlwaysLearning
      Gluten related ??

      By AlwaysLearning · Posted

      Get tested for vitamin deficiencies.  Though neuropathy can be a symptom of celiac, it can also be caused by deficiencies due to poor digestion caused by celiac and could be easier to treat.
    • Colleen H
      Gluten related ??

      By Colleen H · Posted

      Thank you so much for your response  Yes it seems as though things get very painful as time goes on.  I'm not eating gluten as far as I know.  However, I'm not sure of cross contamination.  My system seems to weaken to hidden spices and other possibilities. ???  if cross contamination is possible...I am in a super sensitive mode of celiac disease.. Neuropathy from head to toes
    • Jmartes71
      My only proof

      By Jmartes71 · Posted

      EXACTLY! I was asked yesterday on my LAST video call with Standford and I stated exactly yes absolutely this is why I need the name! One, get proper care, two, not get worse.Im falling apart, stressed out, in pain and just opened email from Stanford stating I was rude ect.I want that video reviewed by higher ups and see if that women still has a job or not.Im saying this because I've been medically screwed and asking for help because bills don't pay itself. This could be malpratice siit but im not good at finding lawyers
    • AlwaysLearning
      My only proof

      By AlwaysLearning · Posted

      We feel your pain. It took me 20+ years of regularly going to doctors desperate for answers only to be told there was nothing wrong with me … when I was 20 pounds underweight, suffering from severe nutritional deficiencies, and in a great deal of pain. I had to figure it out for myself. If you're in the U.S., not having an official diagnosis does mean you can't claim a tax deduction for the extra expense of gluten-free foods. But it can also be a good thing. Pre-existing conditions might be a reason why a health insurance company might reject your application or charge you more money. No official diagnosis means you don't have a pre-existing condition. I really hope you don't live in the U.S. and don't have these challenges. Do you need an official diagnosis for a specific reason? Else, I wouldn't worry about it. As long as you're diligent in remaining gluten free, your body should be healing as much as possible so there isn't much else you could do anyway. And there are plenty of us out here who never got that official diagnosis because we couldn't eat enough gluten to get tested. Now that the IL-2 test is available, I suppose I could take it, but I don't feel the need. Someone else not believing me really isn't my problem as long as I can stay in control of my own food.
    • AlwaysLearning
      Gluten related ??

      By AlwaysLearning · Posted

      If you're just starting out in being gluten free, I would expect it to take months before you learned enough about hidden sources of gluten before you stopped making major mistakes. Ice cream? Not safe unless they say it is gluten free. Spaghetti sauce? Not safe unless is says gluten-free. Natural ingredients? Who knows what's in there. You pretty much need to cook with whole ingredients yourself to avoid it completely. Most gluten-free products should be safe, but while you're in the hypersensitive phase right after going gluten free, you may notice that when something like a microwave meal seems to not be gluten-free … then you find out that it is produced in a shared facility where it can become contaminated. My reactions were much-more severe after going gluten free. The analogy that I use is that you had a whole army of soldiers waiting for some gluten to attack, and now that you took away their target, when the stragglers from the gluten army accidentally wander onto the battlefield, you still have your entire army going out and attacking them. Expect it to take two years before all of the training facilities that were producing your soldiers have fallen into disrepair and are no longer producing soldiers. But that is two years after you stop accidentally glutening yourself. Every time you do eat gluten, another training facility can be built and more soldiers will be waiting to attack. Good luck figuring things out.   
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.