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'eat What You Want' Pill Caution

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Posted 07 March 2006 - 05:56 PM

This article refers to the Zonulin research we have all heard so much about. Claire


The pill makes the gut less ’leaky’ Experts advise caution about claims of a pill that could enable people with diabetes and coeliac disease to eat foods that are normally off-limits.
People with coeliac disease need to avoid wheat and diabetics sugary foods to manage their medical conditions.
Researchers at the University of Baltimore say a pill that makes the gut more watertight could allow these patients to eat whatever they want, says a BBC report.
But the early studies were on rats and experts questioned the implications.

MORE @: http://paktribune.co...x.php?id=136585
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Posted 07 March 2006 - 06:09 PM

I think I would put that pill down to the "If it sounds too good to be true, it probably is" file.
I sure wouldn't trust my health to any pill that hasn't had at least five or ten years of testing.
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Posted 07 March 2006 - 06:48 PM

I don't see how that would be good in any way shape or form. I can only imagine the side effects and long term effects of a more "watertight" intestine. Besides, if you have an autoimmune disorder, how would that stop the reaction? It doesn't make any sense to me.

Aren't there more important things to research than a get-out-of-jail-free card for diabetics and celiacs? It's not a cure, it's like lactaid or something. Only worse. Ephedrine.

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Posted 07 March 2006 - 08:55 PM

Every drug has side effects. What will they be for this one? How much worse than celiac will they be? Why should I pay a lot of money for a pill, when I can control the problem by watching what I eat? And, as Chelse said, how would it stop the reaction? Thanks, but no thanks. This pill is not for me.
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Posted 09 March 2006 - 04:46 AM

I would never touch this pill. For one thing I presented for years with the neurological symptoms, over 30, before the gut problems hit. Gluten is also absorbed by the mucus membranes, the reason many countries do a rectal challange and biopsy, will this pill prevent the mucosal lining of the mouth, esophagus and stomach and rectum from absorbing? Will it only relieve the gut symptoms? Why does our society think we need a pill anyway? Just stop putting this toxic substance in everything, it's not like there are not alternitives, after all.
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celiac 49 years - Misdiagnosed for 45
Blood tested and repeatedly negative
Diagnosed by Allergist with elimination diet and diagnosis confirmed by GI in 2002
Misdiagnoses for 15 years were IBS-D, ataxia, migraines, anxiety, depression, fibromyalgia, parathesias, arthritis, livedo reticularis, hairloss, premature menopause, osteoporosis, kidney damage, diverticulosis, prediabetes and ulcers, dermatitis herpeformis
All bold resoved or went into remission with proper diagnosis of Celiac November 2002
Some residual nerve damage remains as of 2006- this has continued to resolve after eliminating soy in 2007

Mother died of celiac related cancer at 56
Twin brother died as a result of autoimmune liver destruction at age 15

Children 2 with Ulcers, GERD, Depression, , 1 with DH, 1 with severe growth stunting (male adult 5 feet)both finally diagnosed Celiac through blood testing and 1 with endo 6 months after Mom

Positive to Soy and Casien also Aug 2007

Gluten Sensitivity Gene Test Aug 2007
HLA-DQB1 Molecular analysis, Allele 1 0303

HLA-DQB1 Molecular analysis, Allele 2 0303

Serologic equivalent: HLA-DQ 3,3 (Subtype 9,9)



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Posted 09 March 2006 - 09:35 AM

if this drug, with time and testing, proves itself to really work and be safe---i'd jump at the chance to get it for my kids!!
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15 year old twins with celiac, diagnosed dec. 2005
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Posted 09 March 2006 - 10:57 AM

Chrissy, the problem is, that many drugs the FDA considered to be perfectly safe for years were anything but safe, in fact, in many cases, they were killing people. I don't think ANY pills are completely safe, they all have side effects. If you have an illness that would kill you unless you take a certain drug, then the side effects are unavoidable, and you would take the drug anyway, of course. But Celiac disease would only (possibly) kill you if you eat gluten containing foods. There are many foods that are naturally gluten free, and more and more food is available that mimics 'normal' food, that is gluten free also. By the time your kids are grown, it will likely even be easier to find gluten free foods than it is now.

Personally, I'd rather stick to a diet that is sure to have no side effects, unless you want to consider being healthy a side effect! ;)
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Posted 09 March 2006 - 01:13 PM

I think I would ralther stick to the diet I take enough pills as it is already :)
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Posted 09 March 2006 - 02:35 PM

I'd take it only before trying foods that hadn't been prepared by me or had the potential to make me react only because I am so sensitive (no gluten free foods unless they are processed in a dedicated facility). I would however NOT opt to take it if it were an every day thing. At least not until it had been around for awhile and I definitely would still stay gluten-free.
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Posted 09 March 2006 - 03:05 PM

I would not take it so I could eat a "normal" diet that contained gluten. I would consider it, however, for situations where I could be accidently glutened thru CC. Even then, it would depend on what the side effects were, and anything else I would learn about it.
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Posted 09 March 2006 - 03:09 PM

If that were the case, I still probably wouldn't take it.

The gluten-free diet keeps my weight pretty stable and my health good...

If I could have all the "gluten stuff" again, I would gain 30 pounds in the first month -- haha

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Posted 10 March 2006 - 03:32 AM

In my opinion its impossible for me to say I will or I won't. I take a wait and see attitude with this, however I travel all the time, a few times a month at least and I'd welcome something that I could take occasionally when I'm forced to eat in restaurants I'm not sure of. There have been a few times I've gotten gluten this way and I'm sick for a long time, really badly for a week and a funky stomach for 2 weeks. So if it was safe and if it worked I might use it for a stop gap measure.

After reading about wheat and how much its changed over 1000's of years (it in no way resembles the plant it use to be) I honestly don't feel its good for anyone. I'm happy with my celiac diet I eat much healthier then I ever did before. But again, if I could use something here and there it would be nice.

I personally think that "soon" medical researchers will learn how to "turn off" our celiac gene. the advances being made in gene research has the potential to fix us. Now the question is: What does soon mean? I don't think it means next year or even 5 years from now, but I do believe its in my lifetime (I'm 51).

Best, Susan
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Posted 10 March 2006 - 06:59 AM

I would not take it so I could eat a "normal" diet that contained gluten. I would consider it, however, for situations where I could be accidently glutened thru CC. Even then, it would depend on what the side effects were, and anything else I would learn about it.

Exactly.. I would still eat gluten-free, but if wanted to go out to eat ANYPLACE it be nice to have some chance at protection.
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Posted 10 March 2006 - 10:30 AM

I heard Dr. Paterson, the CEO of Alba Therapeutics, speak at a GIG group this past week.

In terms of side effects---he said that study participants experienced little to no side effects. He said participants who had the placebo actually had a higher rate of side effects.

In terms of the leaky guy, etc.....it was fascinating to hear him talk about it. I had never fully understood it until I heard him explain it and show pictures. (the pictures probably helped---but they have some on their website that are helpful). I'll try to explain how he presented it.

We have cells that act as barriers. Previously, researchers thought that the connectors between the cells were more like permanent fences, not letting anything through. Based on research by Dr. Fassano at the University of Maryland, they discovered that they are not fences, but more like gates that can open and close. Dr. Fassano identified "zonulin" which they believe is the "gate" opener and closer. Increased zonulin leads to the opening of the gates. In particular, research done by Dr. Fassano has found that Celiac patients have higher levels of zonulin, which "opens" the barriers. When these gates are opened, the gluten gets through. For people with Celiac, then the autoimmune response occurs.

The purpose of the AT-1001 is to stop the overexpression of zonulin, which in effect, would keep the gates closed, therefore not allowing gluten to permeate the gut, which would prevent the autoimmune reaction from ever occurring. The press release is being issued Monday that states that Phase 1 of the actual testing (on non Celiacs and Celiacs) was successful. It prevented the autoimmune reaction from happening. Their hypothesis was supported.

He believes that the leaky gut/zonulin is a key, if not the key, component of many other autoimmune disorders, including Type 1 diabetes, and potentially Rheumatoid Arthritis and MS (and others). Increased levels of zonulin have been found in Type 1 Diabetes patients, as well.

The pill would be taken like a lactaid---with/before meals that may/do contain gluten (as opposed to popping one each morning.)

Hope this helps shed more light on it.
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Posted 10 March 2006 - 12:10 PM

Laura- Tthank you! That actually sounds pretty darn hopeful. Think of it as a gluten condom :P .
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