Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

All 4 Markers Positive.....

GDLions

Recommended Posts

GDLions Rookie
GDLions
Posted

Sorry I am new here and not sure if this has already been posted...

 

I just got a call from my pediatrician and she said my 3 year old son's blood work came back and all the markers were positive for Celiac.  She said the next step is to get a scope and biopsy done to confirm.  She also suggested the whole family get tested for it.  

 

So my questions are....if all the markers are positive is the scope necessary, doesn't that tell us he has it?  Can all the markers be positive and the scope come back negative?  

 

Thanks for any info you all may have!

 

 

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


powerofpositivethinking Community Regular
powerofpositivethinking
Posted

welcome  :)

 

are the genetic markers you're referring to HLA DQ tests or antibody tests (TTG, DGP, EMA)?

 

If it is the genetic markers of HLA DQ you're referring to then the next step should be to get a complete celiac blood panel drawn.  a complete panel consists of:

 

Comprehensive Celiac Panel:

DGP iga/igg

ttg iga/igg

EMA

Total iga serum-this is a control test to make sure you make enough iga to validate the other testing

check out page 12 in this report for testing information:

Open Original Shared Link

 

If this panel has been drawn then an endoscopy with at least 6 samples taken from the small intestines would be the next step.

 

feel free to post any of your lab results here for others to comment.

 

gluten should continue to be consumed until ALL testing is complete.

 

 

 

 

 

Sorry I am new here and not sure if this has already been posted...

 

I just got a call from my pediatrician and she said my 3 year old son's blood work came back and all the markers were positive for Celiac.  She said the next step is to get a scope and biopsy done to confirm.  She also suggested the whole family get tested for it.  

 

So my questions are....if all the markers are positive is the scope necessary, doesn't that tell us he has it?  Can all the markers be positive and the scope come back negative?  

 

Thanks for any info you all may have!

GFinDC Veteran
GFinDC
Posted

Well, it would be helpful if you got the lab reports and posted them along with the ranges.

 

IMHO, if the antibodies are positive, there is not likely to be a different cause for that.  Antibodies to gliaden are specific to that protein.  Some of the tests are very specific, like the DGP.  But, most doctors want the endoscopy anyway before they will diagnose celiac disease.  Sometimes a doctor will diagnose based on positive antibodies and symptom resolution on the gluten-free diet. But they aren't all going to do that.

 

Something to consider is the ease of testing now vs later.  Getting an endoscopy now before starting the gluten-free diet is the best choice.  If you were to wait until after he was gluten-free for a year and decide to get testing, he would need to go back to eating gluten again for up to 3 months.  That resumed gluten eating can be very unpleasant and sometimes cause other problems.  Reactions to gluten are sometimes more severe after stopping it for awhile and then eating it again.  It's a lifetime diet and it may be easier to stick with it if there is a complete diagnosis.

GDLions Rookie
GDLions
Posted
  • Author

welcome  :)

 

are the genetic markers you're referring to HLA DQ tests or antibody tests (TTG, DGP, EMA)?

 

If it is the genetic markers of HLA DQ you're referring to then the next step should be to get a complete celiac blood panel drawn.  a complete panel consists of:

 

Comprehensive Celiac Panel:

DGP iga/igg

ttg iga/igg

EMA

Total iga serum-this is a control test to make sure you make enough iga to validate the other testing

check out page 12 in this report for testing information:

Open Original Shared Link

 

If this panel has been drawn then an endoscopy with at least 6 samples taken from the small intestines would be the next step.

 

feel free to post any of your lab results here for others to comment.

 

gluten should continue to be consumed until ALL testing is complete.

 

thanks, i will call the doctors office on monday morning and ask for a copy of the results so i can post them and hopefully understand them better.  just so new to this i have no clue :)

  • 2 weeks later...
GDLions Rookie
GDLions
Posted
  • Author

thanks, i will call the doctors office on monday morning and ask for a copy of the results so i can post them and hopefully understand them better.  just so new to this i have no clue :)

Here are the lab results on both of my boys...

Alex

Deam Iga Index 212.3

Gliadin IgA postive

Glia IgG Index 137.9

Gliadin IgG positive

TTG IgA index greater than 100

TTG IgA AB positive

Robert

Deam Iga Index 115.5

Gliadin IgA postive

Glia IgG Index 60.1

Gliadin IgG positive

TTG IgA index greater than 100

TTG IgA AB positive

 

From some studies I have read if the TTG is over 100 there really is no need to do the biopsy.    What do you think?

powerofpositivethinking Community Regular
powerofpositivethinking
Posted

I'd say those are some pretty conclusive results for being celiac!  I'd say the biopsy is up to you.  good luck!

 

Here are the lab results on both of my boys...

Alex

Deam Iga Index 212.3

Gliadin IgA postive

Glia IgG Index 137.9

Gliadin IgG positive

TTG IgA index greater than 100

TTG IgA AB positive

Robert

Deam Iga Index 115.5

Gliadin IgA postive

Glia IgG Index 60.1

Gliadin IgG positive

TTG IgA index greater than 100

TTG IgA AB positive

 

From some studies I have read if the TTG is over 100 there really is no need to do the biopsy.    What do you think?

nvsmom Community Regular
nvsmom
Posted

Wow, it really is unusual to be positive in all celiac tests for an adult, for kids - Wow.

I personally don't think a biopsy is needed but some docs are very by the book and want a patient to jump through hoops before they will diagnose celiac disease. But as you said, when the tTG tests are very high, it is unlikely to be anything else. The DGP and tTG tests are specific to celiac in what causes the villi damage. The AGA tests are positive for gliadin sensitivity. You have blood tests that show damage and indicate gluten sensitivity, unless you suspect other problems or you need a diagnosis for school accommodations that the doc willingly give if biopsies are done, then i would skip the biopsy.

This report discusses the tests on pages 11-12:

Open Original Shared Link

Hope the kids feel better, and I hope your tests are negative.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      132,071
    • Most Online (within 30 mins)
      7,748
    Gigic
    Newest Member
    Gigic
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • AlwaysLearning
      Gluten related ??

      By AlwaysLearning · Posted

      If you're just starting out in being gluten free, I would expect it to take months before you learned enough about hidden sources of gluten before you stopped making major mistakes. Ice cream? Not safe unless they say it is gluten free. Spaghetti sauce? Not safe unless is says gluten-free. Natural ingredients? Who knows what's in there. You pretty much need to cook with whole ingredients yourself to avoid it completely. Most gluten-free products should be safe, but while you're in the hypersensitive phase right after going gluten free, you may notice that when something like a microwave meal seems to not be gluten-free … then you find out that it is produced in a shared facility where it can become contaminated. My reactions were much-more severe after going gluten free. The analogy that I use is that you had a whole army of soldiers waiting for some gluten to attack, and now that you took away their target, when the stragglers from the gluten army accidentally wander onto the battlefield, you still have your entire army going out and attacking them. Expect it to take two years before all of the training facilities that were producing your soldiers have fallen into disrepair and are no longer producing soldiers. But that is two years after you stop accidentally glutening yourself. Every time you do eat gluten, another training facility can be built and more soldiers will be waiting to attack. Good luck figuring things out.   
    • Russ H
      KAN-101 Treatment for Coeliac Disease

      By Russ H · Posted

      This treatment looks promising. Its aim is to provoke immune tolerance of gluten, possibly curing the disease. It passed the phase 2 trial with flying colours, and I came across a post on Reddit by one of the study volunteers. Apparently, the results were good enough that the company is applying for fast track approval.  Anokion Announces Positive Symptom Data from its Phase 2 Trial Evaluating KAN-101 for the Treatment of Celiac Disease https://www.reddit.com/r/Celiac/comments/1krx2wh/kan_101_trial_put_on_hold/
    • Scott Adams
      Nicotine Gum For Gluten Symptoms.. Am I Crazy?

      By Scott Adams · Posted

      BTW, we've done other articles on this topic that I wanted to share here (not to condone smoking!):    
    • Colleen H
      Gluten related ??

      By Colleen H · Posted

      Hi everyone  This has been a crazy year so far... How many people actually get entire sensory overload from gluten or something similar ?  My jaw is going nuts ..and that nerve is affecting my upper back and so on ...  Bones even hurt.  Brain fog. Etc  I had eggs seemed fine.   Then my aid cooked a chicken stir fry in the microwave because my food order shorted a couple key items .   I was so hungry but I noticed light breading and some ingredients with SOY !!! Why are we suffering with soy ? This triggered a sensitivity to bananas and gluten-free yogurt it seems like it's a cycle that it goes on.  The tiniest amount of something gets me I'm guessing the tiny bit of breading that I took one tiny nibble of ...yikes ..im cringing from it .. Feels like my stomach is going to explode yet still very hungry 😔  How long does this last?! Thank you so much 
    • Scott Adams
      Celiac getting dentures

      By Scott Adams · Posted

      This is an older article, but may be helpful.  
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.