Anyone Diagnosed With Biopsy And Had Negative Blood Work?

[Chelle15]

I was tested by a blood panel and it came back with 2 positive markers, however my new GI doctor said that based on the two markers that came back positive he does not think I have it. He still wants me to get a biopsy, but he is doubtful. So I am wondering if there is still a chance I could come back with a positive biopsy. It is not that I wanted to have a disease, but I thought I finally had an answer to my problems. Just curious if anyone had a similar experience. I posted a similar post in pre-diagnosis, sorry if anyone had to read my whining twice. I am just trying to get as many answers and info as possible. THANK YOU!!!!

[Ursa Major]

What were the two positive markers exactly? It sounds to me like he dismisses positive bloodwork as not meaning anything, when he might be totally wrong.

[Chelle15]

Okay, I am going to type exactly what it says, because I am not sure what I need to put down:

IGA: 144

Endmysial IgA Abs: <1:10

Gliadin IgG Abs: 49(H)

Gliadin IgA Abs: 23(H)

Transglutaminas IgA: 4

THANK YOU!

[penguin]

What are the reference ranges?

[Chelle15]

Sorry...here is everything. Thank you for your time.

Component Reference

IgA -- 78-391 mg/dL --144

Endomysial IgA Abs --<1:10

Gliadin IgG Abs-- --Low: < 20 Units --49(H)

Gliadin IgA Abs --Low: < 20 Units --23(H)

Transglutaminas IgA --Low: < 20 Units --4

[Nancym]

Yes! I talk to someone on another message forum who had a positive biopsy with negative blood work. She had completely flattened villi. Dr. Fine's work has also found people with negative blood and positive biopsy. That's why he thinks testing stool is so much better than blood.

[mle-ii]

I don't get it, from the looks of the numbers it looks like you are positive for Celiac if you only go with the bloodwork. What am I missing that the Dr isn't?

[penguin]

I don't get it, from the looks of the numbers it looks like you are positive for Celiac if you only go with the bloodwork. What am I missing that the Dr isn't?

The less specific blood markers are the positive ones, although they are the more sensitive tests. If the TtG is normal, a lot of dr's just write off celiac.

[luvs2eat]

My daughter had inconclusive blood work and a positive endoscopic biopsy.

[nikki-uk]

My husband had negative bloodwork (tTg also) but a positive biopsy.

[Guest Lisa Monet]

Sorry...here is everything. Thank you for your time.

Component Reference

IgA -- 78-391 mg/dL --144

Endomysial IgA Abs --<1:10

Gliadin IgG Abs-- --Low: < 20 Units --49(H)

Gliadin IgA Abs --Low: < 20 Units --23(H)

Transglutaminas IgA --Low: < 20 Units --4

My bloodwork was inconclusive, but I had flattened villi. It looks to me like you are IgA deficient, as am I. From what I've read, an IgA deficiency can distort your blood work results. Dr. Fine diagnosed my celiac disease.

Lisa

[mle-ii]

My bloodwork was inconclusive, but I had flattened villi. It looks to me like you are IgA deficient, as am I. From what I've read, an IgA deficiency can distort your blood work results. Dr. Fine diagnosed my celiac disease.

Lisa

How can you tell that they are IgA deficient? I thought that the first test listed said that they were within the range or am I again misinterpreting. Must be the brain fog.

[Chelle15]

Thank you for all of your responses. It is just so confusing. So if they find out I don't have it does that mean something else is wrong? Or it just gets dropped?

I just want an answer so I can stop feeling so crappy. And I am so used to them telling me nothing is wrong that I clung on tight to the fact that I may have found out what was wrong. So when the GI told me he didn't think I had it I was so disappointed.

Thank you for all of your support.

Just wanted to add, I will be trying a gluten free diet no matter what the results are.

[floridanative]

The less specific blood markers are the positive ones, although they are the more sensitive tests. If the TtG is normal, a lot of dr's just write off celiac.

What about when only your tTg is high (indicating Celiac) and they still write it off as not Celiac. That's what happened to me. Two different docs read my panel and both thought I did not have it. Of couse the biopsy proved them both wrong. My biopsy was done by one of the doubting docs. - boy was his face read when my results came back.

[Chelle15]

Which one(s) is/are the tTg?

[Aerin328]

Just wanted to note that I only had an elevated gliadin IgG antibody (score 57, range max 20) and though I had two doctors tell me it meant nothing, I one that that said, "It is almost definite that you have celiac's disease." That final doctor diagnosed me on the spot w/out a biopsy (which is quite rare). Regardless, I have gone to Enterolab (www.enterolab.com) in hopes of getting a more specific/ conclusive answer, I hear they are great! But just wanted to let you know that your bloodwork certainly does look potentially positive. Also, I've heard that the anti-gliadin antibody IS 100% a sign of reaction to gluten; it just doesn't necessarily mean Celiac disease (which means flattening/damaging of your poor villi).

[Guest Lisa Monet]

How can you tell that they are IgA deficient? I thought that the first test listed said that they were within the range or am I again misinterpreting. Must be the brain fog.

Actually, it must be my brain fog! I just looked at the bottom number for some reason!