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confused Community Regular
confused
Posted

i also had the celiac panel done when i sent in for the enterolab test. I wanted to be sure on all counts. Well I just spoke to my doctor and i am positive for celiac. I guess I am one of the few that didnt need to have the DQ2 or DQ8 gene.

paula

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lonewolf Collaborator
lonewolf
Posted

So what are your genes? I don't have DQ 2 or 8, but I swear I have Celiac (just not willing to do a gluten challenge to prove it). I have at least one copy of DQ3 subtype 7 (my son has two copies of it, so one had to come from me).

confused Community Regular
confused
Posted
  • Author
So what are your genes? I don't have DQ 2 or 8, but I swear I have Celiac (just not willing to do a gluten challenge to prove it). I have at least one copy of DQ3 subtype 7 (my son has two copies of it, so one had to come from me).

I am

Serologic equivalent: HLA-DQ 3,1 (Subtype 7,6)

paula

lonewolf Collaborator
lonewolf
Posted

Thanks. That's very interesting. I've read that DQ3, sub. 7 is almost exactly like DQ8 - I wonder if that's the key. My double DQ3-7 son is very gluten intolerant and it affects his digestive system and his behavior. His tests came out negative, but I think there wasn't enough damage done to show positive, since he's been gluten lite for most of his life.

JerryK Community Regular
JerryK
Posted
i also had the celiac panel done when i sent in for the enterolab test. I wanted to be sure on all counts. Well I just spoke to my doctor and i am positive for celiac. I guess I am one of the few that didnt need to have the DQ2 or DQ8 gene.

paula

Interesting. I took it as fact when I didn't have DQ2 or DQ8, that I didn't have the Celiac gene.

I don't want to know bad enough to go back on Gluten and get a biopsy...but I am certainly interested, being another DQ 3,1 Subtype 7....

Just goes to show you how much we don't know...j

CMCM Rising Star
CMCM
Posted

Well, doctors have really just skimmed the surface of knowledge about celiac disease. While most identified celiacs have DQ2 or 8, not all do. There are other unknown factors at work. With identical twins, who would have the same DNA, there are cases where one twin has celiac disease and the other doesn't. So there are definitely other factors involved. And there have been documented, endoscopy proved celiacs who have neither of the genes. Given the fact that relatively few Americans have been diagnosed thus far (those diagnosed tend to be those with the worst symptoms...thus they seek help and thus they get a diagnosis). But remember the analogy of the iceberg....the diagnosed cases are the tip, and the undiagnosed are the mass under water. So the data on celiac disease is incomplete at this point.

Just remember: those without the celiac gene can be just as sick as those with the gene, and a gluten free diet can help all who react to gluten. If you do not have the officially recognized celiac genes, that does not mean being gluten-free won't help you.

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