What Is The Physiology Of Non-Celiac Gluten Intolerance?

[dws]

I am not sure whether I have celiac disease or just gluten intolerance. I had a fairly high Igg score, but Ttg,IgA normal. Didn't have a biopsy prior to going gluten free. I have read a lot about the body's reaction to gluten if you have celiac, but what about just plain intolerance? What happens? If anyone has any good links to medical studies, that would be great. I know what symptoms people display with intolerance. I am wondering about what is actually going on in your body to cause the reaction. Is it also some sort of immune response?

[mushroom]

Ah, the million dollar question! We had a bit of a discussion about it here:

I have been searching for another reference I thouht I bookmarked, but can't find it yet.

[irish daveyboy]

Ah, the million dollar question! We had a bit of a discussion about it here:

I have been searching for another reference I thouht I bookmarked, but can't find it yet.

Not sure if this is the reference you were searching for or not.

https://www.celiac.com/celiac-disease/understanding-the-genetics-of-gluten-sensitivity-by-dr-scot-lewey-r1032/

Open Original Shared Link

Best Regards,

David

[BethJ]

I saw this article earlier today. It looks like the damage goes on whether you're formally diagnosed or not. The gluten-free diet seems to be imperative for "potential" celiacs. I would think this includes those who are gluten intolerant.

https://www.celiac.com/articles/22389/1/Study-Supports-Gluten-free-Diet-for-Potential-Celiac-Disease-Patients/Page1.html

[dws]

Ah, the million dollar question! We had a bit of a discussion about it here:

I have been searching for another reference I thouht I bookmarked, but can't find it yet.

Thanks for the info!

[BethM55]

Not sure if this is the reference you were searching for or not.

https://www.celiac.com/celiac-disease/understanding-the-genetics-of-gluten-sensitivity-by-dr-scot-lewey-r1032/

Open Original Shared Link

Best Regards,

David

Thank you for the links. I copied and pasted part of one article, and sent it to my mother and sister, both of whom could benefit from testing and a gluten free life, at least IMHO. They're both resistant to change, even though my mom is pretty desperate for pain relief from a couple of different immune based illnesses.

Seems to me that eliminating an inflammation producer from the body can only be helpful, but and again, that's just IMHO , which doesn't always carry much weight with the family. It's their decision, but info to send them might help!

Peace, Beth.

[Marz]

Not sure if this has been posted on this forum before, but this quite informed blogger believes gluten intolerance can be caused by the immune system, outside of the antibody mechanism. It's based on the NK immune cells reacting to gluten directly.

Blog link Open Original Shared Link.

Scientific article on NK cells triggering autoimmunity Open Original Shared Link

[mushroom]

Thank you Marz for a very informative link that has given me a lot of food for thought (if not for my body) I have been interested in NK cells for some time and this adds to my interest. I need MORE!!!