Your Opinions Please :) New To This

[taramck324]

Hi My allergist ran some labs last week and called me saying I had "possible weak positive" results for celiac. I am going to see GI next week but would appreciate any insight! Thanks!!

TTG IGA 4 (negative 0-3, weak positive 4-10, positive 10+)

Immunoglobulin A quant Serum 474 (normal 70-400)

TTG IGG 5 (negative 0-5, weak positive 6-9, positive 9+)

Endomysial Antibody IGA negative

Deamidated gliadin ABS, IGA 18 (negative 0-19, weak positive 20-30, moderate to strong 30+)

Deamidated gliadin ABs, IGG 27 (negative 0-19, weak positive 20-30, moderate to strong 30+)

[samie]

Welcome. Just letting know if you want to get more tests done don't go gluten free yet. Cause it can cause false negatives. Ask questions you want to know I m sure u can get the answers you need. There lots of help on here.

[taramck324]

Thanks! I just am confused by the tests, what does it means if some were weak positive and some were negative?

[mushroom]

Hi My allergist ran some labs last week and called me saying I had "possible weak positive" results for celiac. I am going to see GI next week but would appreciate any insight! Thanks!!

TTG IGA 4 (negative 0-3, weak positive 4-10, positive 10+)

Immunoglobulin A quant Serum 474 (normal 70-400)

TTG IGG 5 (negative 0-5, weak positive 6-9, positive 9+)

Endomysial Antibody IGA negative

Deamidated gliadin ABS, IGA 18 (negative 0-19, weak positive 20-30, moderate to strong 30+)

Deamidated gliadin ABs, IGG 27 (negative 0-19, weak positive 20-30, moderate to strong 30+)

[/quote]

Hi, and welcome to the board. I am not a testing expert or medical professional, but will give you my thoughts. The two results I have bolded are significant, for different reasons. It is *abnormal* to have a high serum IgA - celiacs more often, if their score is out of range, are too low in IgA. I did some googling and found this reference Open Original Shared Link which indicates a possible association with diabetes, which is also prevalent in those with celiac, so it is an interesting finding that your GI should be able to give you more information on. Maybe you need a fasting glucose test if you haven't had one done lately??? Just a thought.

Your Damidated Gliadin Peptide (DGP) (IGG), while in the weakly positive range, is much closer to a positive than a negative. One wonders how long it would be before it went into positive range??? (There are many who regard celiac disease as a progression and much testing information that shows that if you keep testing over the years many negatives eventually become positives - sorry, I don't have a citation to hand for this but will look for one) ETA: here is one: Open Original Shared Link Your DGP IgA was however negative, which is puzzling given that you are a high IgA producer. Normally the IgG results are used if you are a low IgA producer, a factor which invalidates all tests using IgA antibodies. Something else to discuss with your GI.

Your tTG IgA was a weak positive, just over the negative line. However, your tTG IgG was negative and your endomysial antibodies were negative. So what does it all mean????

First of all, you do not have to be positive on every test to be celiac. DGP is the newest of the tests and is considered to be very specific for celiac. I would think that your GI might want to do an endoscopy with biopsies on the basis of this weak positive since it was not *that* weakly positive. I know if it were me, I would want one done based on that finding.

Endomysial antibodies (EMA), before the DGP came along, was always considered to be the most strongly indicative test for celiac. Your tTG results can be high due to other conditions and are not that specific for celiac, although they are specific for antibodies in the gut.

I hope you have a good GI who is familiar with celiac, and I hope he does scope you. Good luck, and keep us informed.