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Help Interpreting Test Results

Sparks

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Sparks Rookie
Sparks
Posted

Hey guys! I just got my celiac results back, and I was hoping for some help with their interpretation. I was strictly gluten-free for a bit over a year before undergoing a gluten challenge for 3 months. All of my tests were negative, except one, which was "low positive". I'm not sure what I should make of this, or how accurate/specific this particular test is.

Anti Endomysial, IgA Negative

Anti Gliadin, IgA 22 (Reference Ranges: <20 U Negative; 20-30 U low positive; >30 U positive)

Anti Gliadin, IgG 6 (Reference Ranges: <20 U Negative; 20-60 U Indeterminate; 61-90 U low positive; >90 U positive)

Anti tTransglutaminase, IgA 3 (Reference Ranges: <20 U Negative; 20-30 U low positive; >30 U positive)

Anti tTrasglutaminase, IgG Negative

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frieze Community Regular
frieze
Posted

Hey guys! I just got my celiac results back, and I was hoping for some help with their interpretation. I was strictly gluten-free for a bit over a year before undergoing a gluten challenge for 3 months. All of my tests were negative, except one, which was "low positive". I'm not sure what I should make of this, or how accurate/specific this particular test is.

Component Your Value Standard Range Units Anti Endomysial, IgA Negative NRN Anti Gliadin, IgA 22 0 - 19 U Anti Gliadin, IgA IgA anti-gliadin reference range: Anti Gliadin, IgA [<20 U negative] Anti Gliadin, IgA [20-30 U low positive] Anti Gliadin, IgA [>30 U positive] Anti Gliadin, IgG 6 0 - 19 U Anti Gliadin, IgG IgG anti-gliadin reference range: Anti Gliadin, IgG [<20 U negative] Anti Gliadin, IgG [20-60 U indeterminate] Anti Gliadin, IgG [61-90 U low positive] Anti Gliadin, IgG [>90 U positive] Anti tTransglutaminase, IgA 3 0 - 19 U Anti tTransglutaminase, IgA IgA anti-tTG reference range: Anti tTransglutaminase, IgA [<20 U negative] Anti tTransglutaminase, IgA [20-30 U low positive] Anti tTransglutaminase, IgA [>30 U positive] Anti tTrasglutaminase, IgG Negative NRN

could you reformat? very difficult to follow...
Sparks Rookie
Sparks
Posted
  • Author

could you reformat? very difficult to follow...

Yup, re-formatted it. Hopefully it's better this way...

frieze Community Regular
frieze
Posted

Yup, re-formatted it. Hopefully it's better this way...

mucho better!
frieze Community Regular
frieze
Posted

Hey guys! I just got my celiac results back, and I was hoping for some help with their interpretation. I was strictly gluten-free for a bit over a year before undergoing a gluten challenge for 3 months. All of my tests were negative, except one, which was "low positive". I'm not sure what I should make of this, or how accurate/specific this particular test is.

Anti Endomysial, IgA Negative

Anti Gliadin, IgA 22 (Reference Ranges: <20 U Negative; 20-30 U low positive; >30 U positive)

Anti Gliadin, IgG 6 (Reference Ranges: <20 U Negative; 20-60 U Indeterminate; 61-90 U low positive; >90 U positive)

Anti tTransglutaminase, IgA 3 (Reference Ranges: <20 U Negative; 20-30 U low positive; >30 U positive)

Anti tTrasglutaminase, IgG Negative.

Ok, positive is positive....as they say....also, I don't see a total IgA on this list. Just because one is positive doesnt mean that is "normal". If your total IgA is low, even just very low normal, that may enlighten the other results. Are you scheduled for a 'scope?

Sparks Rookie
Sparks
Posted
  • Author

Ok, positive is positive....as they say....also, I don't see a total IgA on this list. Just because one is positive doesnt mean that is "normal". If your total IgA is low, even just very low normal, that may enlighten the other results. Are you scheduled for a 'scope?

No total IgA was run. I'm not scheduled for a 'scope. I am confuzzled! What's the accuracy/specificity of the Anti-gliadin IgA test? Are the others more accurate?

ravenwoodglass Mentor
ravenwoodglass
Posted

Did you feel better gluten free? Did you react when you went on the challenge? If the answer to those questions is yes IMHO that combined with your positive blood test should be enough to convince you to get back to being gluten free and stay that way.

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Sparks Rookie
Sparks
Posted
  • Author

Did you feel better gluten free? Did you react when you went on the challenge?

I guess it is acedemic at this point, as I did react--bloating, gas, burping every day for three months--but I suffer from pretty strong self-doubt. When I added gluten back after a month gluten free, I reacted with terrible D. I didn't have the same reaction this time after over a year gluten free, so I worry that it's all in my head. Or something. Self-doubt, ick.

I'm not sure if I should push for an endoscopy or not. On one hand, my doctor replied with this "The weakly positive antigliadin IgA antibody is unlikely to indicate celiac.". On the other, this study from England (Open Original Shared Link) says that people with positive AGA and negative EMA should be 'scoped.

I figured I'd run it by all the smart people on this forum.

GottaSki Mentor
GottaSki
Posted

I think it depends on you. If you have doubts they can become much more pronounced during times while healing. I know if I had not been diagnosed I would have doubted the need to be gluten-free during some of my early days gluten-free.

Knowing what I do now - I agree with Ravenwoodglass that the positive AGA along with dietary response should be enough to stay gluten-free.

If you still have doubts - now is the time to push for the endo and make sure you get all necessary celiac/nutrient testing completed so that you don't have to put yourself through yet another challenge - you are missing Total IgA and DGP (both IgA and IgG). If you haven't had them yet - nutrients Bs, D, K, Iron, Ferritin, Copper and Zinc.

Sparks Rookie
Sparks
Posted
  • Author

I guess I have to decide whether I want to get a refferal to a GI or just say good bye to gluten without talking to one.

Does anyone know what would cause a positive result on the anti-gliadin IgA test, but not the IgG?

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