Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Questions About Cyrex

domesticactivist

Recommended Posts

domesticactivist Collaborator
domesticactivist
Posted

As some of you know I've been doing a gluten challenge after being gluten free for a year (on GAPS for most of it). My doctor did order a standard panel for me, but now I'm considering getting the Open Original Shared Link instead.

My doctor ordered:

Total IgA

Anti Gliadin IgA

Anti Gliadin IgG

Anti tTG IgA

Anti EMA IgA

She couldn't order the Open Original Shared Link test.

Looking at the cyrex array, I see that there is

Deamidated Alpha Gliadin 33 MER IgG ( CPT CODE : 86001-59 )

Deamidated Alpha Gliadin 33 MER IgA ( CPT CODE : 83516-59 )

Are these the same as a Deamidated Gliadin Peptide test? The array also offers other tests which I would find interesting as part of the array - the gluteomorphin, for example. However, the Anti-endomysial Antibody test and the total IgA do not seem to be included.

I KNOW that gluten is a problem for me. The main reason I want the celiac screening is so that I can be aware of whether I have autoimmune gut damage going on as a part of my intolerance, for family reasons and emotional reasons. A smaller side-note... if I don't have indications of autoimmune issues, I may be ok with eventually basing my level of allowable cross-contamination on symptoms rather than absolute avoidance, as I do for my son.

I am leaning toward going with the cyrex array 3 and then if all my IgA numbers are low, getting the total IgA tested, if Deamidated Alpha Gliadin is the same as the Deamidated gliadin peptide test.

But I did want the EMA test. I have a call out to my doctor to find out the cost of the tests ordered, since I have to pay for everything out of pocket. Doing the tests in a phased approach is not possible because I need to stop eating gluten ASAP!!!

What do you think?

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Skylark Collaborator
Skylark
Posted

The Cyrex array does look interesting. The Deamidated Alpha Gliadin 33 MER is the test you're wanting, the one often called DGP.

You might also look at the panels this company offers. They have a celiac panel with total IgA, EMA, TTG, and DGP. There is also DGP IgG and IgA available alone if you just want to supplement what your Dr. has ordered.

Open Original Shared Link

Open Original Shared Link

EMA is going to be relatively expensive. It is a hand-read histological test that checks whether your antibodies bind to monkey esophagus so it's much more labor-intensive than an ELISA like TTG or DGP. Cyrex looks to be only running ELISAs which is why they are not offering it. I'm not sure I would order EMA if I were paying out of pocket. DGP is more sensitive, and TTG has been identified as the main antigen in endomysium.

domesticactivist Collaborator
domesticactivist
Posted
  • Author

Yeah, I've looked at all their panels! They also have a panel for assessing cross-reactive foods, and another to determine the specific causes of leaky gut... but funds are limited.

Since the Cyrex test does include DGP (thanks for clarifying), I am very much leaning toward it. I think this whole panel is only about $360. My dr's office still hasn't called me back about costs or ordering from Cyrex (which I'm sure will require a bunch of extra paperwork) but I am thinking that's the direction I'm going to go, rather than with the EMA.

Do you think the idea of only ordering the total IgA if IgA numbers come back low is a good idea? I'm assuming it doesn't matter whether I'm eating gluten or not for that one.

Skylark Collaborator
Skylark
Posted

Do you think the idea of only ordering the total IgA if IgA numbers come back low is a good idea? I'm assuming it doesn't matter whether I'm eating gluten or not for that one.

I think it's fine if you don't mind being stuck twice. Personally I'd be on pins and needles wondering about IgA if everything came back low so I'd get the total IgA at the same time. :lol: Gluten won't matter for total IgA.

researchmomma Contributor
researchmomma
Posted

Yeah, I've looked at all their panels! They also have a panel for assessing cross-reactive foods, and another to determine the specific causes of leaky gut... but funds are limited.

Since the Cyrex test does include DGP (thanks for clarifying), I am very much leaning toward it. I think this whole panel is only about $360. My dr's office still hasn't called me back about costs or ordering from Cyrex (which I'm sure will require a bunch of extra paperwork) but I am thinking that's the direction I'm going to go, rather than with the EMA.

Do you think the idea of only ordering the total IgA if IgA numbers come back low is a good idea? I'm assuming it doesn't matter whether I'm eating gluten or not for that one.

I ordered the Celiac Panel from ineedlabs.com and it was 200 dollars for the panel which included EMA. AND I didn't need a doctor to order it. They use LabCorp.

domesticactivist Collaborator
domesticactivist
Posted
  • Author

Open Original Shared Link

I see! I've been scared to use these kinds of services. I found another one that offered the cyrex labs without a doctor, but they had typos and grammar errors all over and were trying to sell some digestive enzyme to deal with being glutened, so I just couldn't trust them.

I'm glad to hear you had a positive experience with i need labs. They don't have all the tests cyrex does, but they do have total iga, ttg, ema, dgp, antigliadin igg and iga. I wish my partner would come home and discuss it with me already!

My doctor's office still hasn't gotten back to me... but it finally occurred to me that my (new) naturopath could also order these tests for me just as easily, and I can get her on the phone or by email, no problem!

I'll be happy to be thinking straight again.

domesticactivist Collaborator
domesticactivist
Posted
  • Author

Yay! I just got a call back from my dr office. I can get the panel listed at the top for $169.36 + a 15.96 fee. Blood draw scheduled for 11:10 AM.

I found the deamidated gliadin peptide test available for $89 online. I'm considering ordering it.

OR, I could order this celiac panel for $177.25 but It doesn't inlcude the anti gliadin IgA or Igg, but does include the EMA, DGP, tTG, and total IgA.

I could get a blood draw with that tomorrow if I want to.

Which would you do?

The cyrex test did have more things listed and I've heard (but not confirmed) that it's about $360. I'm now thinking I'll skip it, since it would be more hassle to order and I'm not convinced of the value added.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Skylark Collaborator
Skylark
Posted

Great!

That's a tough call what to get. Since you know you're gluten intolerant and it's autoimmunity you are concerned with, how would you even interpret the old anti-gliadin? It's not very specific for celiac autoimmunity.

domesticactivist Collaborator
domesticactivist
Posted
  • Author

Good news! I called the lab at my doctor's office and asked if they could now order the DGP or just let me order some of the tests in their panel so I could order the rest online. It turns out that since my celiac panel was ordered 2 months ago they have changed what's in it. Now their standard screening includes the DGP test! Progress :)

As for interpreting the old anti gliadin - I guess it's just one more piece of validation I might be able to get to help me with my hypochondria about having hypochondria rather than anything physically wrong with me. :rolleyes:

Skylark Collaborator
Skylark
Posted

That is good news. I hope you get the positive test you're looking for. Good luck!

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      131,597
    • Most Online (within 30 mins)
      7,748
    Angel1009
    Newest Member
    Angel1009
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.4k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • Wheatwacked
      Potential celiac need advice

      By Wheatwacked · Posted

      Yes.  Now, if you hit your finger with a hammer once, wouldn't you do your best not to do it again?  You have identified a direct connection between gluten and pain.  Gluten is your hammer.  Now you have to decide if you need a medical diagnosis.  Some countries have aid benefits tgat you can get if you have the diagnosis, but you must continue eating a gluten-normal diet while pursuing the diagnosis. Otherwise the only reason to continue eating gluten is social. There are over 200 symptoms that could be a result of celiac disease.. Celiac Disease and Non Celiac Gluten Sensitivity  both cause multiple vitamin and mineral deficiency.  Dealing with that should help your recovery, even while eating gluten.  Phosphatidyl Choline supplements can help your gut if digesting fats is a problem,  Consider that any medications you take could be causing some of the symptoms, aside from gluten.        
    • trents
      Potential celiac need advice

      By trents · Posted

      Welcome to the forum, @Ben98! If you have been consciously or unconsciously avoiding gluten because of the discomfort it produces then it is likely that your blood antibody testing for celiac disease has been rendered invalid. Valid testing requires regular consumption of generous amounts of gluten. The other strong possibility is that you have NCGS (Non Celiac Gluten Sensitivity) which shares many of the same symptoms with celiac disease but does not have the autoimmune component and thus does not damage the small bowel lining. It is 10x mor common than celiac disease. There is currently no test for NCGS. Celiac disease must first be ruled out. Some experts in the field believe it can be a precursor to the development of celiac disease. Having one or both of the primary genes for developing celiac disease does not imply that you will develop active celiac disease. It simply establishes the potential for it. About 40% of the population has the genetic potential but only about 1% develop active celiac disease. 
    • Ben98
      Potential celiac need advice

      By Ben98 · Posted

      TTG blood test and total IGA tested on many occasions which have always remained normal, upper GI pain under my ribs since 2022. I had an endoscopy in 2023 which showed moderate gastritis. no biopsy’s were taken unfortunately. genetic test was positive for HLADQ2. extreme bloating after eating gluten, it’ll feel like I’ve got bricks in my stomach so uncomfortably full. the pain is like a dull ache under the upper left almost like a stitch feeling after a long walk. I am just wanting some advice has anyone here experienced gastritis with a gluten issue before? thank you  
    • Wheatwacked
      Unusual bright yellow but odourless discharge

      By Wheatwacked · Posted

      "Conclusions: The urinary iodine level was significantly lower in women with postmenopausal osteoporosis, and iodine replacement may be important in preventing osteoporosis"  Body iodine status in women with postmenopausal osteoporosis Low iodine can cause thyroid problems, but Iodine deficiency will not show up in thyroid tests.  Iodine is important for healing, its job is to kill off defective and aging cells (Apoptosis). Skin, brain fog, nails, muscle tone all inproved when I started taking 600 mcg (RDA 150 - 1000 mcg) of Liquid Iodine drops. Some with dermatitis herpetiformis, Iodine exacerbates the rash.  I started at 1 drop (50 mcg) and worked up to 12 drops, but I don't have dermatitis herpetiformis.
    • cristiana
      How long does it take to gain weight?

      By cristiana · Posted

      That's great news, you can do this.  Let us know how things go and don't hesitate to ask if you have any more questions. Cristiana 😊
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.