Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Blood Tests......what Is Correct?

bobtom

Recommended Posts

bobtom Rookie
bobtom
Posted

My 11 year old son has been complaining of stomach aches, off and on, for the last 8-10 months. Pediatrician ordered gliadin IGA (deamidated peptide) which came back 67 (<20 normal). Referred to GI and he said that test isn't very reliable and ordered a tTG IGA and total serum IGA (which I am assuming is normal since he had an elevated gliadin to begin with). I was under the impression from what I have been reading that the gliadin test he had done is pretty reliable. Just wondering thoughts on that and is it common to have that test be high and the tTG IGA be low? If so, what would that indicate? This is all very confusing. Thank you!!

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


nvsmom Community Regular
nvsmom
Posted

I think gliadin IgA is considered innaccurate because it has a higher false negative rate than ttg IgA... I think.

I think gliadin IgA indicates celiac. If it has a low specificity (meaning it could test positive for other problems) I would have the GI or pediatrician explain what those possible causes are instead of brushing it off as he he did. :huh:

He sounds like the type of GI that you'll need to see with a list of documented info on the test results to get the doctor on board. Your son is way above normal...what else does he think it is?

Good luck.

GottaSki Mentor
GottaSki
Posted

From what I understand that your son's high DGP IgA indicates Celiac Disease even if the tTG IgA is currently negative.

Here is one journal article that talks about DGP IgA as a useful tool in children because the DGP antibodies may show up before tTG antibodies in blood and is better at monitoring compliance once gluten free.

Open Original Shared Link

It is a small study - used this to illustrate my point. There are other studys with much larger sampling groups that you can find with a simple google search.

Your situation is the exactly the reason doctors should run the ENTIRE Celiac Blood Panel when there are symptoms in children. Looking at one test at a time prolongs an already difficult diagnosis process.

It was correct for your GI to order more Celiac blood tests, but it looks like your still hasn't had an Endomysial IgA or any IgG testing. Did the GI order any nutrient tests? Does he have direct experience with Celiac Disease? This can make a big difference if you decide to proceed with endoscopy/biopsy.

I have the same question as nvsmom - if the GI doesn't think the DGP IgA indicates Celiac Disease, what does he think the test means?

bobtom Rookie
bobtom
Posted
  • Author

Thanks for your replies. He did not order any nutrient tests and he didnt offer any explanation to the high result if it isn't celiac. He pretty much blew off that he thought it could be celiac, but he said we needed to "contend" with the high DGP. He did very briefly mention that if the tTG comes back negative, he may do a biopsy, but he said it so quickly and brushed over it and on to other things. My son had his tTG drawn this weekend, I will let you know what is was. I am very interested to see what it is and where we proceed from there. Can and elevated DGP indicate anything else?? Thanks for your time!

frieze Community Regular
frieze
Posted

My 11 year old son has been complaining of stomach aches, off and on, for the last 8-10 months. Pediatrician ordered gliadin IGA (deamidated peptide) which came back 67 (<20 normal). Referred to GI and he said that test isn't very reliable and ordered a tTG IGA and total serum IGA (which I am assuming is normal since he had an elevated gliadin to begin with). I was under the impression from what I have been reading that the gliadin test he had done is pretty reliable. Just wondering thoughts on that and is it common to have that test be high and the tTG IGA be low? If so, what would that indicate? This is all very confusing. Thank you!!

the IgA version is more sensitive, but less specific, than the IgG version. So they should be ordered together.

GottaSki Mentor
GottaSki
Posted

Can and elevated DGP indicate anything else?? Thanks for your time!

Gliadin is one of two proteins in gluten. Upon digestion proteins are broken down into peptides. A positive DGP IgA shows that antibodies are being created to fight these peptides specific to gluten.

I don't know of anything other than a problem with gluten being the cause of a positive DGP IgA. Anyone else?

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      132,035
    • Most Online (within 30 mins)
      7,748
    bostonbell
    Newest Member
    bostonbell
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • Jmartes71
      Fighting for a name

      By Jmartes71 · Posted

      Thankyou so much for your words.Its a hard battle when a supposed well known hospital whose celiac " specialist " has down played me because my colon looks fine and put it in my medical and so pcp doesn't take seriously. In their eyes we all carry that gene.Im having alot of bad days trying to be positive because of it.
    • Scott Adams
      Celiac getting dentures

      By Scott Adams · Posted

      Your experience is both shocking and critically important for the community to hear, underscoring the terrifying reality that cross-contamination can extend into the most unexpected and invasive medical devices. It is absolutely devastating that you had to endure six months of sickness and ultimately sustain permanent vision loss because a doctor dismissed your legitimate, life-altering condition. Your relentless research and advocacy, from discovering the gluten in MMA acrylic to finding a compassionate prosthodontist, is a testament to your strength in a system that often fails celiac patients. While the scientific and medical consensus is that gluten cannot be absorbed through the skin or eyes (as the molecules are too large to pass through these barriers), your story highlights a terrifying gray area: what about a substance *permanently implanted inside the body*, where it could potentially shed microparticles or cause a localized immune reaction? Your powerful warning about acrylic lenses and the drastic difference with the silicone alternative is invaluable information. Thank you for sharing your harrowing journey and the specific, severe neurological symptoms you endure; it is a stark reminder that celiac is a systemic disease, and your advocacy is undoubtedly saving others from similar trauma.
    • Scott Adams
      Dedicated gluten-free Restaurants in East Bay (near San Francisco):

      By Scott Adams · Posted

      Those are driving distance from me--I will try to check them out, thanks for sharing!
    • Scott Adams
      Fighting for a name

      By Scott Adams · Posted

      I am so sorry you're going through this bad experience--it's difficult when your own lived reality of cause and effect is dismissed by the very professionals meant to help you. You are absolutely right—your violent physical reactions are not "what you think," but undeniable data points, and it's a form of medical gaslighting to be told otherwise, especially when you have a positive HLA-DQ2 gene and a clear clinical picture. Since your current "celiac specialist" is not addressing the core issue or your related conditions like SIBO and chronic fatigue, it may be time for a strategic pivot. Instead of trying to "reprove" your celiac disease to unwilling ears, consider seeking out a new gastroenterologist or functional medicine doctor, and frame the conversation around managing the complications of a confirmed gluten-free diet for celiac disease. Go in and say, "I have celiac disease, am strictly gluten-free, but I am still suffering from these specific complications: SIBO, chronic fatigue, dermatological issues, and high blood pressure linked to pain. I need a partner to help me address these related conditions." This shifts the focus from a debate about your diagnosis to a collaborative plan for your current suffering, which is the help you truly need and deserve to work toward bouncing back.
    • NanCel
      Celiac getting dentures

      By NanCel · Posted

      Hello, no I had to have them re done and then used a liner over the top.  Many dentists are not aware of the celiac effects.  Best of luck.   There is other material, yet, very expensive.
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.