Progesterone pills - are they gluten free??

[knitty kitty]

Progesterone stimulates the thyroid.  The thyroid stimulates the immune system which increases production of IgG antibodies.  

Progesterone Upregulates Gene Expression in Normal Human Thyroid Follicular Cells

https://pmc.ncbi.nlm.nih.gov/articles/PMC4454767/

Celiac Disease and Autoimmune Thyroid Disease: The Two Peas in a Pod

https://pmc.ncbi.nlm.nih.gov/articles/PMC9312543/

 

[Wheatwacked]

On 3/19/2025 at 11:14 PM, Mettedkny said:

my Gliadin IgG numbers suddenly went up to 59

Elevated estrogen or fluctuations in estrogen can contribute to leaky gut and cause elevated anti-gliadin IgG in people with celiac disease who are on a gluten-free diet, 

High levels of progesterone have been shown to decrease gut permeability.

Talk to your doctor about a vacation from the estrogen, from your decription it looks to be the culpret. 

How is your vitamin D?

[Mettedkny]

 

1 hour ago, Wheatwacked said:

Elevated estrogen or fluctuations in estrogen can contribute to leaky gut and cause elevated anti-gliadin IgG in people with celiac disease who are on a gluten-free diet, 

High levels of progesterone have been shown to decrease gut permeability.

Talk to your doctor about a vacation from the estrogen, from your decription it looks to be the culpret. 

How is your vitamin D?

Thank you for your response. I'd love to read more about your suggestion, everything I find online speaks to the opposite. Unfortunately I need the HRT due to many other factors (post menopause symptoms and osteoporosis) so stopping the estrogen would be very unfortunate.

Vitamin D is pretty good, not great, but now below the norm at 36

[knitty kitty]

Vitamin D acts as a hormone and influences other hormones if the Vitamin D level is at eighty nmol/l or above.  

I had a lot of hormone problems when my Vitamin D was in single digits prior to diagnosis of celiac disease.  Vitamin D is needed to keep bones strong and helps regulate the immune system, lowering inflammation.  

I used high dose Vitamin D 3 to correct my deficiency quickly.  It's very safe and recommended by doctors.  Take Vitamin D 3, not the D 2 form prescribed frequently.  D2 is not utilized as well as D 3.  Thiamine is needed to activate Vitamin D in the body.  

Interesting Reading:

Safety of High-Dose Vitamin D Supplementation: Secondary Analysis of a Randomized Controlled Trial

https://pubmed.ncbi.nlm.nih.gov/31746327/

High-Dose Vitamin D Supplementation Can Correct Hypovitaminosis D Prior to Total Knee Arthroplasty

https://pubmed.ncbi.nlm.nih.gov/34737019/

The short-term effect of high dose vitamin D3 supplementation in improving hypovitaminosis in patients with type 2 diabetes - A randomized clinical trial

https://pubmed.ncbi.nlm.nih.gov/35470105/

The role of vitamin D in menopausal women’s health

https://pmc.ncbi.nlm.nih.gov/articles/PMC10291614/#:~:text=Vitamin D (VD) is known,menopause are also increasingly prominent.

Edited August 25 by knitty kitty
Added link

[Mettedkny]

2 hours ago, knitty kitty said:

Vitamin D acts as a hormone and influences other hormones if the Vitamin D level is at eighty nmol/l or above.  

I had a lot of hormone problems when my Vitamin D was in single digits prior to diagnosis of celiac disease.  Vitamin D is needed to keep bones strong and helps regulate the immune system, lowering inflammation.  

I used high dose Vitamin D 3 to correct my deficiency quickly.  It's very safe and recommended by doctors.  Take Vitamin D 3, not the D 2 form prescribed frequently.  D2 is not utilized as well as D 3.  Thiamine is needed to activate Vitamin D in the body.  

 

My vitamin D is a bit low, but now too low, and I have just started taking 5000 IU again. In the past I have done 50.000 IUs at times to get the levels up higher, and might try that again, after I speak to my doc this week.

[Wheatwacked]

The Calgary VSafety of High-Dose Vitamin D Supplementation - full text - Something I have noticed, reports ol hypercalcification occur only when calcium supplements are used.

Quote

"Calcium supplementation was initiated if dietary calcium intake was less than 1200 mg/day...  In the present study, median serum calcium concentrations were similar for each of the 3 vitamin D doses throughout 3 years of follow-up. Hypercalcemia was most common in participants taking vitamin D 10 000 IU/day, although episodes were infrequent, mild, and transient. Two-thirds of these episodes occurred in participants taking a calcium supplement, discontinuation of which invariably resulted in normalization of serum calcium.

 

Quote

 

Incidence of hypercalciuria and hypercalcemia during vitamin D and calcium Supplementation in older women

It is notable that hypercalcemia and hypercalciuria occurs in the placebo group that received only calcium and placebo vitamin D so even a modest calcium supplementation of 600 mg day may be too high for some women.

 

Quote

 

The role of vitamin D in menopausal women’s health

Most current studies suggest that adequate VD supplementation in perimenopausal and postmenopausal women may be beneficial in reducing cancer risk.

In summary, VD insufficiency is a common but neglected health problem in healthy menopausal women. VD status is associated with skeletal muscle, cardiovascular disease, diabetes, GSM, and menopausal symptoms in menopausal women.

 

 

[Scott Adams]

5 hours ago, Mettedkny said:

My vitamin D is a bit low, but now too low, and I have just started taking 5000 IU again. In the past I have done 50.000 IUs at times to get the levels up higher, and might try that again, after I speak to my doc this week.

Definitely consult with your doctor before considering such high doses--5,000 IU is likely fine, but 50,000 IU could cause serious issues over time.

[trents]

Yes, 50k IU daily would be an a short term front end loading dose for those having critically low levels but you wouldn't want to take it for an extended period. 

[Wheatwacked]

Yes, it is important to get 25OHD blood and PTH tested and monitored.  My doctor tests me 4 times a year along with homocysteine and the other blood panels.  Massive vitamin D doses under a doctors care can raise vitamin D level quickly, but those doses wear off in about three months, so either sun or supplementation needs to be instituted in order to not lose the gain.  There have been numerous clinical trials on kidney transplant patients with doses as high a 1.5million IU with no ill effects.  But those are a one time bolus under the care of doctors.  One conumdrus of these really high  dose supplements is a higher incidence of falls.  The answer is that the patient feels so good, they are more active than usual before regaining strength and balance.

Quote

Vitamin D intoxication associated with hypercalcemia, hyperphosphatemia, and sup pressed parathyroid hormone level is typically seen in patients who are receiving massive doses of vitamin D in the range of 50,000 to 1 million IU/d for several months to years. Ekwaru et al16 recently reported on more than 17,000 healthy adult volunteers participating in a preventative health program and taking varying doses of vitamin D up to 20,000 IU/d. These patients did not demonstrate any toxicity, and the blood level of 25(OH)D in those taking even 20,000 IU/d was less than 100 ng/mL.

https://www.mayoclinicproceedings.org/article/S0025-6196(15)00244-X/pdf

 

Quote

 

“Our own NIH-sponsored, FDA-oversight trials have dosed pregnant and lactating women with up to 6,000 IU per day for months and have not had a single adverse event due to the vitamin D, Hollis said.

“When combined with supplemental magnesium, vitamin D repletion has dramatically changed my practice,” said McCarthy, whose family practice is affiliated with The Memorial Hospital of Belleville, Ill. “There are now very few patients with infections, and asthmatics who are coming off medications are staying off of them. Elevations in blood pressure now require many fewer medications,”  -Dave McCarthy, MD

https://www.healio.com/news/endocrinology/20120325/surge-of-information-on-benefits-of-vitamin-d-but-no-interventional-trial-data-exist-yet-to-ensure-s