Celiac In Families?

[Kasey'sMom]

Hi, I'm trying to get some information in how celiac disease runs in families. My dd has celiac disease and I just found out that I have celiac disease. My father and his mother have both been tested and had negative tests. I have two cousins on my father's side the have celiac disease as well.

My mother has not been tested yet and my husband and his family haven't been tested. I'm really hoping that they will all get tested.

We saw my dd Dr. today and he said that the celiac disease is a recessive gene. He said that my husband's family probably has the celiac disease gene as well.

For those of you that have a family history of celiac disease, was it on your mom's, dad's or both sides of the family?

Thanks for the insight!

[MySuicidalTurtle]

It is from my Mothers side of the family.

[lovegrov]

Probably both. Definitely on father's.

richard

[Kasey'sMom]

Thanks for the information. I was really confused after my dd appointment yesterday. From what I've read the celiac disease does not follow the "typical" recessive gene pattern and can be passed on be mother and/or father. The gene can be from both sides of the family, but it's not required. Does this sound correct?

[mommida]

My daughter has both DQ2 and DQ8. That suggests it was from both mother and father doesn't it? You only need to have one gene to be diagnosed.

Laura

[frenchiemama]

My dad and his first cousin have it (who knows who else). I'm sure my brother has it, but he's young and stubborn and doesn't want to get tested. My sister tested negative but feels better on a gluten-free diet. My mom has severe symptoms and tested negative, but her doctor (also my doctor) says that she should try the diet anyway. My mom's (late) sister had a "grain allergy" and severe "eczema" which I think was celiac disease and DH (like me). My mom's side of the family also has a large amount of type 1 diabetes and mental illness, which I am convinced are related to gluten intolerance in some cases.

[bluelotus]

Hi,

I study population genetics and most genes don't follow that "typical" recessive path that we are taught in basic bio....very few do. Most genes interact with one another, exacerbating or negating various conditions. Certain conditions aren't determined by one gene either, but by the presence/absence of many. That is why things like cancer are so hard to predict genetically..... (remember, we have over 30,000 genes, try predicting that one, yikes!!)

That said, I have come across some information on the inheritance. It said that with one first degree relative (full sibling or parent) with celiac disease, you have a 10% chance of having it. Also, I've read women are more likely to develop it than men. The only people in my family that have been diagnosed are my mother and I (I am female, hence the name), but there are plenty of suspects in my family...then again, they don't want to hear about, but we've all been there.

Anyway, hope the info helps.

[sb4480]

Hmmm....lets see....we have a long family tree of celiac disease

On my father's side:

My paternal grandmother was diagnosed as an adult but probably had it ages before then. She also had alzheimers. Does anyone know if there's a link between the two?

My father suspects he might have it. He's constantly in the bathroom.

My older brother has severe celiacs

I have it

I don't know much about that side of the family, most of my grandmothers siblings passed away before i was born. I don't think there's a link on my grand father's side but I don't know them well

On my mom's side

My grandfather was never diagnosed with celiac disease but he died of colon cancer

My mother's 1st cousin has celiac disease and DH

His brother has celiac disease

I suspect my mom has celiac disease.

There's definitely a familial link here.

Stephanie

[Kasey'sMom]

Yes this does help. My dad has classic celiac disease symptoms but his panel was negative. I think I convinced him to do the gene test since several others on his side of the family have it. My mother may get tested as well because she has un-explained pain etc. My mother-in law also has classic symptoms but I'm not sure she would ever commit to the gluten-free lifestyle even if she was positive. My husband said he would be willing to do the test as well.

I thought the Dr. was incorrect.. Thanks for the the insight!!

I would love start a support group in my area and I needed to get my stuff straight.

[hez]

For me there seems to be evidence that the celiac disease comes from my Mom's side of the family. My Mom might have celiac disease but does not want the endoscopy so she is just gluten-free. My maternal grandma has "stomach issues" and I suspect it is celiac disease.

I am not sure on my Dad's side but there are other auto immune diseases there.

I think it is very possible both of my parents carry the gene.

Hez

[luvs2eat]

Maybe both, but definitely from my mom. I think my sister and brother had the DH form, but are not interested in being tested as there are meds for skin stuff... even tho I've explained the small intestine damage, they're not interested. Yikes!

[Guest BellyTimber]

"C(o)eliac disease" is a construct based on procedures and an arbitrary form of phenomenon in the intestine.

In real life there are so many forms of variation on the symptoms, intestinal and non-intestinal, of gluten and wheat sensitivity, and also more people will not be diagnosed with the immense range of relevant conditions than diagnosed, and in most cases a diagnosis of a relevant condition will not be linked to this sensitivity.

On that basis I see it on both sides of my family tree with my dad's side having more emphasis on intestinal symptoms.