-
Welcome to Celiac.com!
You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.
-
Celiac.com Sponsor (A1):
Celiac.com Sponsor (A1-M):
-
Get Celiac.com Updates:Support Our Content
Doctors
Share experiences with doctors, how to find a good one, and avoid the bad ones.
1,808 topics in this forum
-
- 3 replies
- 3k views
-
- 5 replies
- 2.1k views
-
- 0 replies
- 1.2k views
-
- 2 replies
- 2.7k views
-
- 2 replies
- 1.5k views
-
- 3 replies
- 1.8k views
-
- 5 replies
- 2.2k views
-
- 5 replies
- 2k views
-
- 0 replies
- 2k views
-
Celiac.com Sponsor (A10):
Celiac.com Sponsor (A10):
-
- 2 replies
- 4k views
-
- 1 reply
- 1.5k views
-
- 1 reply
- 1.6k views
-
- 5 replies
- 4.1k views
-
- 1 reply
- 1.4k views
-
- 6 replies
- 4.2k views
-
- 0 replies
- 1.3k views
-
- 2 replies
- 3.4k views
-
- 2 replies
- 1.7k views
-
- 3 replies
- 2.8k views
-
- 5 replies
- 3.2k views
-
- 8 replies
- 2.5k views
-
- 1 reply
- 1.9k views
-
- 0 replies
- 1k views
-
- 10 replies
- 2.6k views
-
- 3 replies
- 1.2k views
Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8-M):
-
Get Celiac.com Updates:Support Celiac.com:
-
Celiac.com Sponsor (A17):
Celiac.com Sponsor (A17):
Celiac.com Sponsors (A17-M):
-
Recent Activity
-
- trents replied to Seabeemee's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms1Labs ? Awaiting in person follow up with my GI
Welcome to the celiac.com community, @Seabeemee! The fact that the genetic testing shows you do not have either of the two genes associated with the potential to develop celiac disease (HlA DQ2 and HLA DQ8) pretty much ensures that you do not have celiac disease and the biopsy of the small bowel showing "normal villous architecture" confirms this. But... -
- Seabeemee posted a topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms1Labs ? Awaiting in person follow up with my GI
My Doctor messaged me that I have no sign of Celiac disease so until I meet with her next week I don’t know what the labs mean. I am being evaluated by my new GI for Celiac disease because of digestive issues (bloating, distention, fullness in mid section, diarrhea). I also have been diagnosed with GERD and some associated issues hence the endoscopy. ... -
- Scott Adams commented on Scott Adams's article in Diagnosis, Testing & Treatment7A Future Beyond the Gluten-Free Diet? Scientists Test a New Cell Therapy for Celiac Disease (+Video)
The link at the bottom of the article is the source: https://www.science.org/doi/10.1126/scitranslmed.adr8941- celiac disease
- cell therapy
- (and 8 more)
-
- trents replied to mike101020's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms3
EMA Result
Let me hasten to add that if you will be undergoing an endoscopy/biopsy, it is critical that you do not begin efforts to reduce gluten beforehand. Doing so will render the results invalid as it will allow the small bowel lining to heal and, therefore, obscure the damage done by celiac disease which is what the biopsy is looking for. -
- Scott Adams replied to Mary D63's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease21
Violent reaction to gluten after going gluten-free?
This article, and the comments below it, may be helpful:
-
-
Celiac.com Sponsor (A19):
-
Member Statistics
-
Celiac.com Sponsor (A20):
-
Celiac.com Sponsor (A22):
-
Forum Statistics
-
Total Topics121.5k
-
Total Posts1m
-
-
Celiac.com Sponsor (A21):
-
Upcoming Events
-
0January 21, 2026 11:15 PM
Until
January 22, 2026 12:15 AM
-
0January 27, 2026 11:30 PM
Until
January 28, 2026 12:30 AM
-
0February 04, 2026 11:00 PM
Until
February 05, 2026 12:00 AM
-
-
Posts
-
Welcome to the celiac.com community, @Seabeemee! The fact that the genetic testing shows you do not have either of the two genes associated with the potential to develop celiac disease (HlA DQ2 and HLA DQ8) pretty much ensures that you do not have celiac disease and the biopsy of the small bowel showing "normal villous architecture" confirms this. But you could have NCGS (Non Celiac Gluten Sensitivity) which would not damage the villous architecture. You could also have SIBO (Small Intestine Bacterial Overgrowth) or H. Pylori infection. And with your resection of the small bowel, that could be causing it's own problems like you describe. When was that surgery done?
-
My Doctor messaged me that I have no sign of Celiac disease so until I meet with her next week I don’t know what the labs mean. I am being evaluated by my new GI for Celiac disease because of digestive issues (bloating, distention, fullness in mid section, diarrhea). I also have been diagnosed with GERD and some associated issues hence the endoscopy. I also was diagnosed with NAFLD after an abdominal CT scan in December - which surprises me because I gave up alcohol 5 years ago, workout 5 days a week, cardio / weights and cook from scratch every night. Anecdotally, I do feel better when I do not eat a lot of carbs and have been staying away from gluten 95% of the time until my follow up. History: I had an emergency bowel obstruction operation in August 2021 for a double closed loop obstruction, open surgery removed 40 cm of my small intestine, my appendix, cecal valve and illeocectomy. Beside the fact that this put me in the situation of no longer being able to absorb Vitamin B12 from my diet and having to inject Vit B 12 2x a month, I also became Iron deficient and am on EOD iron to keep my levels high enough to support my Vitamin B12 injections, as well as daily folic acid. I tested positive for pernicious anemia in 2022 but most recently that same test came back negative. Negative Intrinsic Factor. My results from the biopsies showed 2nd part of Duodenum, small bowel Mildly patch increased intraepithelial lymphocytes with intact villious architecture. Comment: Duodenal biopsies with normal villous architecture and increased intrepithelial lymphocytes (Marsh I lesion) are found in 1-3% of patients undergoing duodenal biopsy, and an association with celiac disease is well established however the specificity remains low. Similar histologic findings may be seen in H pylori gastritis, NSAID and other medication use including olmesartan, bacterial overgrowth, tropical sprue and certain autoimmune disorders. So my GI ordered Labs for Celiac confirmation: Sorry I couldn’t upload a photo or pdf so typed below: TEST NAME IN RANGE and/or RESULTS RESULTS: IMMUNOGLOBULIN A : 110 GLIADIN (DEAMIDATED) AB (IGG, IGA) <1.0 GLIADIN (DEAMIDATED) AB (IGA) <1.0 GLIADIN (DEAMIDATED) AB (IGG) <1.0 TISSUE TRANSGLUTAMINASE ANTIBODY, IGG, IGA TISSUE TRANSGLUTAMINASE AB, IGG <1.0 TISSUE TRANSGLUTAMINASE AB, IGA <1.0 INTERPRETATION: <15.0 ANTIBODY NOT DETECTED > OR = 15.0 ANTIBODY DETECTED RESULTS: HLA TYPING FOR CELIAC DISEASE INTERPRETATION (note The patient does not have the HLA-DQ associated with celiac disease variants) More than 97% of celiac patients carry either HLA-DQ2 (DQA1*05/DQB1*02) or HLA-DQ8 (DQA1*03/DQB1*0302) or both. Genetic counseling as needed. HLA DQ2 : NEGATIVE HLA D08: NEGATIVE HLA VARIANTS DETECTED: HLA DA1* : 01 HLA DA1* : 05 HLA DQB1*: 0301 HLA DQB1*: 0501 RESULTS REVIEWED BY: Benjamin A Hilton, Ph.D., FACMG I appreciate any input, thank you.
-
Let me hasten to add that if you will be undergoing an endoscopy/biopsy, it is critical that you do not begin efforts to reduce gluten beforehand. Doing so will render the results invalid as it will allow the small bowel lining to heal and, therefore, obscure the damage done by celiac disease which is what the biopsy is looking for.
-
By Scott Adams · Posted
This article, and the comments below it, may be helpful: -
By Scott Adams · Posted
That’s a really tough situation. A few key points: as mentioned, a gluten challenge does require daily gluten for several weeks to make blood tests meaningful, but negative tests after limited exposure aren’t reliable. Dermatitis herpetiformis can also be tricky to diagnose unless the biopsy is taken from normal-looking skin next to a lesion. Some people with celiac or DH don’t react every time they’re exposed, so lack of symptoms doesn’t rule it out. Given your history and family cancer risk, this is something I’d strongly discuss with a celiac-experienced gastroenterologist or dermatologist before attempting a challenge on your own, so risks and benefits are clearly weighed.
-
