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Decoding My Serology?


peanutbutterandjelly

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peanutbutterandjelly Newbie

After a few months of nasty gut issues, one episode of bloating to the point where I couldn't move my legs without extreme pain and finally getting sick of it, I had bloods done a couple of weeks ago, which apparently have come back positive. I have a print of them sitting in front of me, an appointment for a gastroscopy next week. Feeling terrible today, and not 100% sure this is going to even make sense. Or if things are different internationally, I'm in Australia. 

 

My serology came back with:

Deaminated Gliadin IgG (Phadia 250): positive 14.0 

 

h-tTG IgA (Phadia 250): positive 42.0

 

IgA (Total) (Abbott Architect): 2.69 g/L (0.6o-3.96)

 

[please note new reference ranges]

 

Note underneath says both are indicative of coelic disease. 

 

 

Is there a high rate of these showing up and being incorrect, or indicative of something else? I think at the moment I'm in a state of disbelief that it's something as simple as eradication of something from my diet which could fix how I'm feeling right now. 

 

 


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kareng Grand Master

They are considered very accurate. Welcome to the club!

Open Original Shared Link

"In blood tests, are false positives less common than false negatives?

Even though blood tests are quite accurate, they are falsely positive 1-3% of the time (i.e., being positive without the person having celiac) and, although less commonly, falsely negative 1-2% of the time (i.e., being normal when a person actually has celiac)."

frieze Community Regular

does she get her decoder ring??

They are considered very accurate. Welcome to the club!

Open Original Shared Link

"In blood tests, are false positives less common than false negatives?
Even though blood tests are quite accurate, they are falsely positive 1-3% of the time (i.e., being positive without the person having celiac) and, although less commonly, falsely negative 1-2% of the time (i.e., being normal when a person actually has celiac)."

peanutbutterandjelly Newbie

Ooh, I'd love a decoder ring. Costume included?? 
 

kareng Grand Master

Ooh, I'd love a decoder ring. Costume included??

Due to budget cuts, your decoder ring may be delayed. Costumes are optional.

mushroom Proficient

Actually, due to an overflow of applicants, there is a rather long waiting list for decoder rings.  As with healing from celiac disease, one must be very patient.

nvsmom Community Regular

Yeah... I still haven't got my ring!

;)


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peanutbutterandjelly Newbie

Worth a shot :P 
 

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      thank you RMJ! That is very helpful advice. Good to know we aren’t crazy if we don’t do the endoscopy. We are going to try the gluten free and see how symptoms and levels improve.    thank you Wheatwacked (love the username lol) that is also reassuring. Thankfully she has an amazing and experienced pediatrician. And yesss I forgot to mention the poop! She has the weirdest poop issues.    How long did it take y'all to start seeing improvement in symptoms? 
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      So her tissue transglutaminase antibody is almost 4x the upper end of the normal range - likely a real result. The other things you can do besides an endoscopy would be: 1.  Genetic testing.  Unfortunately a large proportion of the population has genes permissive for celiac disease, but only a small proportion of those with the genes have it. With family history it is likely she has the genes. 2.  Try a gluten free diet and see if the symptoms go away AND the antibody levels return to normal. (This is what I would do). Endoscopies aren’t always accurate in patients as young as your daughter. Unfortunately, without an endoscopy, some doctor later in her life may question whether she really has celiac disease or not, and you’ll need to be a fierce mama bear to defend the diagnosis! Be sure you have a good written record of her current pediatrician’s diagnosis. Doing a gluten challenge for an endoscopy later in life could cause a very uncomfortable level of symptoms.   Having yourself, your husband and your son tested would be a great idea.  
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      here are the lab ranges.  Normal ranges for tissue transglutaminase are: <15.0 Antibody not detected > or = 15.0 Antibody detected normal for endomysial antibody is < 1.5. So she is barely positive but still positive. 
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      I have been diagnosed with coeliacs disease today after endoscopy, bloods and CT scan. I have also been diagnosed with Mesenteric Panniculitis today. Both of which I believe are autoimmune diseases. I have been told I will need a dexa scan and a repeat CT scan in 6 months. I had not even heard of Mesenteric Panniculitis till today. I don’t know much about it? Has anyone else got both of these. 
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