Jump to content
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

No Genetic History - Original Mutation?


absullivan6

Recommended Posts

absullivan6 Rookie

My 2.5 year old was diagnosed this past summer with celiac.  I've always had major stomach issues, so I immediately got the full blood panel which shockingly to me, came back negative.  I don't have active celiac, nor the gene for it.  My husband just got his panel back and like me, is completely negative.
I'm surprised by these results as I know celiac is mostly genetic.  My poor son's luck that he is the original mutation...

Anyone else have this in their family?


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



kareng Grand Master

Did you get the specific genetic tests done?  The Celiac panel usually doesn't contain that.

absullivan6 Rookie

Yes, they did the full genetic test on both of us.

kareng Grand Master

Perhaps he was incorrectly diagnosed?  Does he have a gene? I have never heard of a genetic mutation for this.  It might not be possible....

LauraTX Rising Star

Was it verified that the son has a known gene for Celiac disease?

ravenwoodglass Mentor

Is your son improving on the diet? Did they test your total IGA? If you have your results posting them here could be helpful  Have you tried the diet yourself strictly? If you haven't given the diet a trial you should. There are rare celiacs that don't have either of the two most common celiac associated genes. There are non celiac gluten intolerant folks who have to be just as strict with the diet as blood and biopsy diagnosed celiacs. 

BlessedMommy Rising Star

Is it possible to get celiac via a recessive gene?


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



kareng Grand Master

Is it possible to get celiac via a recessive gene?

A genetic test wouldn't matter if its recessive or not- it finds what genes you have . I Have never heard that there are any recessive

Celiac genes?

BlessedMommy Rising Star

Just curious because my husband and I both have brown eyes and ended up with a blue eyed child. I wondered if celiac worked the same way.

kareng Grand Master

Trying to I post on phone -

For example - I think CF is caused by a recessive gene if I remember right? So having 1 gene for CF and the other corresponding gene for healthy - no CF. Both parents give the child a gene for CF - the kid has CF.

Celiac genes work differently. You have 1 or more and they sit quietly and do nothing in 29% of people. In that lucky 1%, something turns 1 or more on and the Celiac fun begins.

Simple genetic explanation from a phone. Lol

kareng Grand Master

Just curious because my husband and I both have brown eyes and ended up with a blue eyed child. I wondered if celiac worked the same way.

. But if they looked at your eye color genes- they would see that each of you had a brown and a blue gene. They could match up with 1 from each of you. The genetics of eye color is actually more complex than that, but that's the simple explanation.
  • 2 weeks later...
absullivan6 Rookie

I wanted to update everyone that I had my son's gastro look at my lab results and I do carry a gene.  She explained that the way the labs report things makes it very confusing for people to read, including doctors that aren't gastros.  In this case, my primary care didn't read the report as well as a gastro did and said I was negative.  If anyone else is in this situation I would recommend having a gastro read your report, not a primary care, or some other doctor.

KenzMom Rookie

Wow! I am glad you found some answers! I totally agree with you on seeing a GI for any of these issues-- I just took my daughter to the GI yesterday and realized that the pediatrician has been very misinformed--as a result, I was misinformed too. I wish I took her to a GI a long time ago! 

Archived

This topic is now archived and is closed to further replies.


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      132,443
    • Most Online (within 30 mins)
      7,748

    Nannie J
    Newest Member
    Nannie J
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • Scott Adams
      This is an older article, but still helpful:  
    • cristiana
      It's strange because I'm pretty sure not too long ago I picked up a loaf of bread with B vitamins, but I can't find a single one now.  Probably cutbacks, everyone's trying to save money now!
    • Scott Adams
      Eating grains typically depletes certain B vitamins, so I'm not sure why they decided to fortify with calcium and iron, but hopefully we'll see more B vitamin fortification in gluten-free products going forward.
    • Rogol72
      @HAUS, I was at an event in the UK a few years back. I remember ringing the restaurant ahead to inquire about the gluten free options. All I wanted was a few gluten free sandwiches, which they provided and they were delicious. The gluten-free bread they used was Warbutons white bread and I remember mentioning it on this site before. No harm in trying it once. It's fortified with Calcium and Iron. https://www.warburtonsglutenfree.com/warbs_products/white-loaf/ The only other gluten-free bread that I've come across that is fortified is Schar with Iodized salt, nothing else.
    • Scott Adams
      In the U.S., most regular wheat breads are required to be enriched with certain B-vitamins and iron, but gluten-free breads are not required to be. Since many gluten-free products are not enriched, we usually encourage people with celiac disease to consider a multivitamin.  In the early 1900s, refined white flour replaced whole grains, and people began developing serious vitamin-deficiency diseases: Beriberi → caused by a lack of thiamin (vitamin B1) Pellagra → caused by a lack of niacin (vitamin B3) Anemia → linked to low iron and lack of folate By the 1930s–40s, these problems were common in the U.S., especially in poorer regions. Public-health officials responded by requiring wheat flour and the breads made from it to be “enriched” with thiamin, riboflavin, niacin, and iron. Folic acid was added later (1998) to prevent neural-tube birth defects. Why gluten-free bread isn’t required to be enriched? The U.S. enrichment standards were written specifically for wheat flour. Gluten-free breads use rice, tapioca, corn, sorghum, etc.—so they fall outside that rule—but they probably should be for the same reason wheat products are.
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.