Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Background Heritage Question

CMCM

Recommended Posts

CMCM Rising Star
CMCM
Posted

After reading all my celiac realted books, they keep stressing that celiac disease has a higher prevalence in people with Northern European/Irish/Italian heritage. I'm curious about that....what are your backgrounds on both parents' sides?

I'll start....for me, Swedish on my Dad's side, and on my mom's side Germanic/Russian/English. So I definitely fit that profile.

How about the rest of you?

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Bonnie Explorer
Bonnie
Posted

I was born in Scotland and my heritage is all Scottish!!

Yvonne

taweavmo3 Enthusiast
taweavmo3
Posted

Part Irish from my mother's side, and Greek from my father's side. I'm not sure where the celiac genes came from.....my mom's entire family has intestinal issues, but my father's family on the maternal side all had stunted growth and late maturity. His mother was only 4'10. So maybe both, who knows. I would love to have them all gene tested, but I don't think I can get everyone to cooperate! All of my kids (only one actually tested +) have gluten reactions and are now gluten free. My brother, me and I believe my late sister (if she was still here to be tested, she was bipolar, and only 4'9 at maturity) have celiac as well. Only my other older sister seems symptom free. So it's very pervasive in my family, which I think is really interesting.

RoseNNJ Apprentice
RoseNNJ
Posted

100 percent Italian :D

hungryforlife Apprentice
hungryforlife
Posted

My Mom's Side

GM (Scotch-Irish) Grandfather:(English- ancestor was John Wesley)

Dad's side:

Don't know? His last name was Ellis so I assume English.

jerseyangel Proficient
jerseyangel
Posted

Italian--both sides :D

penguin Community Regular
penguin
Posted

sweedamickacanuckaho

Sweedish (dad)

Irish (mom)

French-Canadian (dad)

Native American (mom)

Blindingly pale, easily burned, redhead personality :D

Do I fit the profile, or what :P

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Rachel--24 Collaborator
Rachel--24
Posted

Moms side....Italian/Spanish

Dad's side....Mexican (I dont know if there's anything mixed in with that)

It had to come from my mom. <_<

mrsnj91 Explorer
mrsnj91
Posted

Wow this is interesting!

We are having my DD tested for this so I will give you HER parents background ;) .....

Me-Irish, Spanish and American Indian

Daddy's-English and Polish

Just from the few responses....your books seem right! I will have to show my husband this as we were just talking about this over the weekend!

Added: I was looking over the responses again and noticed that some said only one side that fit that discripition. I heard a ped. GI speak this weekend and she said that BOTH parents have to carry the gene. Not necessarily have Celiac but carry the gene(s). Interesting how some on here have one parent that doesn't fit the 'mold'. Just some food for thought! I just found this post interesting.

CMCM Rising Star
CMCM
Posted
  • Author

Since the theory is that those areas most recently exposed to gluten/wheat would have the HIGHEST rates of celiac disease, and those areas which have eaten gluten the longest have the lowest rates (because natural selection over several thousand years has been eliminating the celiacs!!!), I would expect the very highest rates to be in Native Americans!!! There was a woman here back in January who was Native American, but I haven't seen her around for awhile. I wonder how many others are celiac and don't know it?

Another interesting thing....the original cultivated wheat did not have nearly as much gluten as the wheat does today. Because of the desirable qualities of wheat in cooking (lightness and puffiness in baking), wheat has actually been developed to have a much higher gluten content that the original wheat did, so I guess people are more affected now.

Anyhow, this is all intereting....

francelajoie Explorer
francelajoie
Posted

Both parents are French Canadians

mrsnj91 Explorer
mrsnj91
Posted

The GI said that North Europian decent where at higher risk. But if you go by your theory with the American Indian then I gave a double whammy there! LOL! My guess is that American Indians had more of a corn intake as their base for grain?

Interesting on the grains evolving. I can see that.

Ursa Major Collaborator
Ursa Major
Posted

100% German

DingoGirl Enthusiast
DingoGirl
Posted

One-quarter Norwegian and the rest, Scottish, Irish, English.

I think there was another thread juts like this running the last few days, also inspired by that book (I'm waiting for my copy!). Seemed to me that it had gotten to be several pages....check it out!

Rachel--24 Collaborator
Rachel--24
Posted
Added: I was looking over the responses again and noticed that some said only one side that fit that discripition. I heard a ped. GI speak this weekend and she said that BOTH parents have to carry the gene. Not necessarily have Celiac but carry the gene(s). Interesting how some on here have one parent that doesn't fit the 'mold'. Just some food for thought! I just found this post interesting.

Someone can correct me if I'm wrong but as far as I know both parents do not need to have a celiac gene in order for the child to aquire a gene. You only need one Celiac gene to develop the disease and you can get that from either parent.

CMCM Rising Star
CMCM
Posted
  • Author
Someone can correct me if I'm wrong but as far as I know both parents do not need to have a celiac gene in order for the child to aquire a gene. You only need one Celiac gene to develop the disease and you can get that from either parent.

I asked that of Dr. Fine when I got my test results, and he confirmed that you only actually need one celiac gene to have a predisposition. You get one gene from each parent, so you could get one celiac gene, plus a second gene from the other parent that was some non-gluten related gene, so you either could get celiac or you might not, 50% chance I guess.

gfmelissa Apprentice
gfmelissa
Posted

My parents are portuguese and the other is english/german.

I am wondering more about that GI you heard speak that said both parents have to be carriers of the gene? did they mention what the theory is on that? If not thats cool, just wondering.

danikali Enthusiast
danikali
Posted

I don't fit the profile. I'm mostly Polish and a little bit German. Unless somewhere down the line there is something else that I don't know about. But how could you not know?

CMCM Rising Star
CMCM
Posted
  • Author
My parents are portuguese and the other is english/german.

I am wondering more about that GI you heard speak that said both parents have to be carriers of the gene? did they mention what the theory is on that? If not thats cool, just wondering.

No no no....I specifically asked Dr. Fine about this once...both parents do not have to give you a gene. You need only ONE gene to have problems. If you have TWO genes (one from each parent) your likelihood of having problems is far greater, however. And there are some people with no identified genes that have celiac disease, so there are obviously some genes that are related to this which have not yet been identified. I think it's about 1% with that scenario.

Smunkeemom Enthusiast
Smunkeemom
Posted

wow. it's difficult to answer. It's my girls who have celiac, and other people in my family. My mother is Irish/Scotish, and that's the side the celiac is on, so I suppose that's the answer.

luvs2eat Collaborator
luvs2eat
Posted

Both parents are Scottish/Irish.

Angelina Newbie
Angelina
Posted
After reading all my celiac realted books, they keep stressing that celiac disease has a higher prevalence in people with Northern European/Irish/Italian heritage. I'm curious about that....what are your backgrounds on both parents' sides?

I'll start....for me, Swedish on my Dad's side, and on my mom's side Germanic/Russian/English. So I definitely fit that profile.

How about the rest of you?

1/2 Irish from my father (who i dont know)

Scottish, Native American.. Mother side

I know who I got my genes from! grrr

nikki-uk Enthusiast
nikki-uk
Posted
No no no....I specifically asked Dr. Fine about this once...both parents do not have to give you a gene. You need only ONE gene to have problems. If you have TWO genes (one from each parent) your likelihood of having problems is far greater, however. And there are some people with no identified genes that have celiac disease, so there are obviously some genes that are related to this which have not yet been identified. I think it's about 1% with that scenario.

I was trying to explain this to my 16 yr old son (who has symptoms and we want to get tested)

He wanted to know the chances of him having celiac disease.(His Dad has biopsy proven celiac disease-no gene test though)

I (tried) to explain to him that assuming his Dad has one of the two HLA markers that predispose you to celiac disease,he may have passed that gene onto him(but not necessarily so).

And even if he has passed the gene onto him,there has to be a 'trigger' for celiac disease to occur(illness, huge stress etc.)

And of course I (his Mum) may carry the gene too,(I don't have celiac disease).

In which case he would have 2 genes for celiac disease,or 1 or none.

Did everyone follow that? :blink::lol:

CMCM Rising Star
CMCM
Posted
  • Author
I was trying to explain this to my 16 yr old son (who has symptoms and we want to get tested)

He wanted to know the chances of him having celiac disease.(His Dad has biopsy proven celiac disease-no gene test though)

I (tried) to explain to him that assuming his Dad has one of the two HLA markers that predispose you to celiac disease,he may have passed that gene onto him(but not necessarily so).

And even if he has passed the gene onto him,there has to be a 'trigger' for celiac disease to occur(illness, huge stress etc.)

And of course I (his Mum) may carry the gene too,(I don't have celiac disease).

In which case he would have 2 genes for celiac disease,or 1 or none.

Did everyone follow that? :blink::lol:

It makes perfect sense to me. Awareness is the key....but knowing the genes from both parents is great because then you really have a firmer idea. Obviously if you have been diagnosed celiac you have at least ONE gene, but if like me, you find out you have TWO genes, then you know for sure your kids have at least one problem gene. For me, the wild card is my husband....being Irish & Norwegian he just might have one, but we don't know. I guess getting one celiac/gluten gene from each parent might mean your likelihood of eventual problems is greater than with just one. Since I have two, I therefore know my two kids have one or the other of my genes, therefore they have the predisposition at the very least and should be watching for it throughout their lives. Lacking any sort of real symptoms now, they certainly don't want to change their diets or even think about it much, but down the road if something triggers symptoms, at least they know where to start looking.....whereas I was kind of oblivious to the idea for most of my life! :D

Guest mvaught
Guest mvaught
Posted

Irish

French

Native American

German

Welch

luck of the Irish?

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. Mari
      - Mari replied to Jmartes71's topic in Coping with Celiac Disease
      2

      Related issues

      Hi Jmartes, It sure is difficult to get useful advice from medical providers. Almost 20 years ago a Dr suggested that I might have Celiacs and I took a Celiac Panel blood test. No gluten challenge diet. On that test the tTG was in normal range but an alpha antibody was very high. I went online and read about celiac disease and saw how I could investigate...
    2. MogwaiStripe
      - MogwaiStripe replied to annamarie6655's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      2

      Airborne Gluten?

      I can't prove it, but I truly believe I have been glutened by airborne particles. I used to take care of shelter cats once per week at a pet store, and no matter how careful I was, I would get glutened each time even if I wore a mask and gloves and washed up well after I was done. I believe the problem was that because I'm short, I couldn't do the the tasks...
    3. knitty kitty
      - knitty kitty replied to Midwestern's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      16

      Gluten Issues and Vitamin D

      Hello, @MogwaiStripe, Vitamin D is turned into its activated forms by Thiamine. Thiamine deficiency can affect Vitamin D activation. https://pubmed.ncbi.nlm.nih.gov/14913223/ Thiamine deficiency affects HLA genes. HLA genes code for autoimmune diseases like Celiac, Thyroiditis, Diabetes, etc. Thiamine deficiency inside a cell triggers a...
    4. knitty kitty
      - knitty kitty replied to annamarie6655's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      2

      Airborne Gluten?

      Hello, @annamarie6655, Yes, there's many of us who react to airborne gluten! Yes, animal feed, whether for chickens or cats or dogs, can release airborne gluten. I can get glutened from the bakery section at the grocery store. The nose and mouth drain into the digestive system and can trigger systemic reactions. I find the histamine release...
    5. Scott Adams
      - Scott Adams replied to Butch68's topic in Gluten-Free Foods, Products, Shopping & Medications
      3

      Guinness, can you drink it?

      This article may be helpful:
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      132,243
    • Most Online (within 30 mins)
      7,748
    Dorfor
    Newest Member
    Dorfor
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • Mari
      Related issues

      By Mari · Posted

      Hi Jmartes, It sure is difficult to get useful advice from medical providers. Almost 20 years  ago a Dr suggested that I might have Celiacs and I took a Celiac Panel blood test. No gluten challenge diet. On that test the tTG was in normal range but an alpha antibody was very high. I went online and read about celiac disease and saw how I could investigate this low tTG and still have celiac disease. Normal tTG can happen when a person had been reacting for many years. Another way is that the person has not been eating enough gluten to raise the antibody level. Another reason is that the tTG does not show up on a blood but may show up on a fecal test. Almost all Celiacs inherit at least one of the 2 main Celiac genes. I had genetic tests for the Celiac genes at Enterolab.com. I inherited one main Celiac gene from one parent and the report said that the DQ gene I inherited from my other parent, DQ6, could cause a person to have more problems or symptoms with that combination. One of my grandmother's had fairly typical symptoms of Celiacs but the other grandmother had severe food intolerances. I seem to show some problems inherited from both grandmothers. Human physiology is very complex and researchers are just beginning to understand how different body systems interact.  If you have taken an autosomal DNA test you can download your raw data file and upload it to Prometheuw.com for a small fee and search for Celiac Disease. If you don't find any Cekiac genes or information about Celiac disease  you may not have autoimmune gluten intolerance because more than 99% of Celiacs have one or both of these genes.  PLEASE ASK QUESTIONS IF YOU WANT TO KNOW EHAT i HAVE DONE TO HELP WITH SYMPTOMS.  
    • MogwaiStripe
      Airborne Gluten?

      By MogwaiStripe · Posted

      I can't prove it, but I truly believe I have been glutened by airborne particles. I used to take care of shelter cats once per week at a pet store, and no matter how careful I was, I would get glutened each time even if I wore a mask and gloves and washed up well after I was done. I believe the problem was that because I'm short, I couldn't do the the tasks without getting my head and shoulders inside their cages, and so the particles from their food would be all over my hair and top of my shirt. Then I had to drive home, so even if I didn't get glutened right then, the particles would be in my car just waiting for me to get in the car so they could get blown into my face again. I gave up that volunteer gig and stopped getting glutened so often and at such regular intervals.
    • knitty kitty
      Gluten Issues and Vitamin D

      By knitty kitty · Posted

      Hello, @MogwaiStripe, Vitamin D is turned into its activated forms by Thiamine.  Thiamine deficiency can affect Vitamin D activation. https://pubmed.ncbi.nlm.nih.gov/14913223/ Thiamine deficiency affects HLA genes.  HLA genes code for autoimmune diseases like Celiac, Thyroiditis, Diabetes, etc.  Thiamine deficiency inside a cell triggers a toggle switch on the gene which in turn activates autoimmune diseases carried on the gene.  The reference to the study is in my blog somewhere.  Click on my name to go to my page, scroll down to the drop down menu "Activities" and click on blogs.  
    • knitty kitty
      Airborne Gluten?

      By knitty kitty · Posted

      Hello, @annamarie6655, Yes, there's many of us who react to airborne gluten!   Yes, animal feed, whether for chickens or cats or dogs, can release airborne gluten.  I can get glutened from the bakery section at the grocery store.   The nose and mouth drain into the digestive system and can trigger systemic reactions.   I find the histamine release in response to airborne gluten will stuff up my sinuses and bother my eyes.  High histamine levels do cause anxiety and migraines.  The muscle spasms can be caused by high histamine, too.  The digestive system may not manifest symptoms without a higher level of gluten exposure.   Our bodies make an enzyme, DAO (diamine oxidase), to break down histamine.   Pyridoxine B 6, Cobalamine B12, Vitamin C, copper, zinc, and iron are needed to make DAO.  DAO supplements are available over the counter.  Taking a B Complex supplement and additional Thiamine in the form Benfotiamine or TTFD (tetrahydrofurfuryl disulfide) helps reduce the amount of histamine being released.  Mast cells without sufficient Thiamine have an itchy trigger finger and release histamine at the slightest provocation.  Thiamine helps mast cells refrain from releasing their histamine.    I find taking additional TTFD thiamine helps immensely with neurological symptoms as TTFD can easily cross the blood brain barrier without a carrier.  High histamine in the brain can cause the muscle spasms, anxiety and migraines.  Vitamin C really helps with clearing histamine, too.   The Digiorno pizza mystery reaction could have been caused by a reaction to the cheese.  Some people develop lactose intolerance.  Others react to Casein, the protein in dairy, the same as if to gluten because Casein resembles the molecular structure of gluten.  An enzyme used in some dairy products, microbial transglutaminase, causes a gluten reaction because it is the same as the tissue transglutaminase our bodies make except microbes make it.  Those tTg IgA blood tests to diagnose celiac disease measure tissue transglutaminase our bodies release as part of the autoimmune response to gluten.   You're doing great!  A Sherlock Holmes award to you for figuring out the connection between airborne gluten and animal feed!!!  
    • Scott Adams
      Guinness, can you drink it?

      By Scott Adams · Posted

      This article may be helpful:  
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.