Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Celiac Disease Vaccine Shows Promising Results in Phase I Trial - Science Daily (press release)

Scott Adams

Recommended Posts

Scott Adams Grand Master
Scott Adams
Posted

Open Original Shared Link

Science Daily (press release)

ScienceDaily (May 8, 2011) — The world's first potential vaccine for celiac disease has shown promising results for treating celiac disease in a Phase I clinical trial and is expected to move to Phase II trials within the next year. ...

Open Original Shared Link

Open Original Shared Link

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


GlutenFreeManna Rising Star
GlutenFreeManna
Posted

I'm having difficulty understanding this--how can they make a vaccine when Celiac is not caused by a virus? Also will this help those that already have active celiac or only possibly prevent it from presenting in those with the most common genes? If it works, will they withhold it from people that are not formally diagnosed? And what are the risks? I think I will stick with just eating a mostly whole food gluten-free diet instead....

AgainstTheGrainIdaho Rookie
AgainstTheGrainIdaho
Posted

I'm having difficulty understanding this--how can they make a vaccine when Celiac is not caused by a virus? Also will this help those that already have active celiac or only possibly prevent it from presenting in those with the most common genes? If it works, will they withhold it from people that are not formally diagnosed? And what are the risks? I think I will stick with just eating a mostly whole food gluten-free diet instead....

Makes you wonder huh? Kind of like the vaccine for cervical cancer? Hmmm....Who knows? I know they are trying things for diabetes too though. Weird. Don't get it. Would it really work? I guess we'll see.

ravenwoodglass Mentor
ravenwoodglass
Posted

Makes you wonder huh? Kind of like the vaccine for cervical cancer? Hmmm....Who knows? I know they are trying things for diabetes too though. Weird. Don't get it. Would it really work? I guess we'll see.

It does make one wonder. The vaccine for cervical cancer is a vaccine for the HPV virus. Or rather for a couple of the strains of the HPV as there are more than just one. It is thought that the HPV virus is a contributing factor in the development of cervical cancer. It is however not the only cause of cervical cancer and selling it as a cancer 'vaccine' is IMHO kind of dishonest use by big pharma of a scare factor to sell more of the vaccine.

Since celiac is not a virus I also wonder how they are going to develop a vaccine for it and if they do what will be the side effects. It seems to me that money would be better spent in trying to develop more sensitive tests for celiac and educational programs for doctors and the general population. It is Celiac Disease Awareness Month, or is it? I know I haven't seen any news blurbs about it.

Kate79 Apprentice
Kate79
Posted

It sounds to me to be similar to those de-sensitizing trials they do with some peanut allergy sufferers. They give the patient a minute amount of peanut, and gradually up the dosage until the body is used to it and more and more can be tolerated. With this, it sounds like they've found a way to gradually de-sensitize patients to gluten.

From the article, I wonder whether people would have to do these shots all the time? It mentions a once-weekly shot for three weeks... If that's the case, staying gluten free might be preferable! Also - it only mentions that it'll work for 90% of DQ2 people - nothing about DQ8 markers or those who are 'just' gluten intolerant.

GlutenFreeManna Rising Star
GlutenFreeManna
Posted

It sounds to me to be similar to those de-sensitizing trials they do with some peanut allergy sufferers. They give the patient a minute amount of peanut, and gradually up the dosage until the body is used to it and more and more can be tolerated. With this, it sounds like they've found a way to gradually de-sensitize patients to gluten.

From the article, I wonder whether people would have to do these shots all the time? It mentions a once-weekly shot for three weeks... If that's the case, staying gluten free might be preferable! Also - it only mentions that it'll work for 90% of DQ2 people - nothing about DQ8 markers or those who are 'just' gluten intolerant.

Not to mention that even if they successfully reintroduce gluten without negative reactions this study has no way of predicting the long term effects. Drs used to think that kids outgrew celiac disease, now they know differently and for the kids that were told they outgrew it and then later had worse symptoms the consequences to their heatth could be great if they don't realize they need to go gluten free again. IMO, eating gltuen without any short-term consequences is not worth the risk of the long term developments like cancer.

Mack the Knife Explorer
Mack the Knife
Posted

Here are some more articles about the research:

Open Original Shared Link

Open Original Shared Link

Open Original Shared Link

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Roda Rising Star
Roda
Posted

Even if it does work it wouldn't help me with my avenin sensitivity...

"In our Phase I trial, we saw a Nexvax2®-specific T-cell response that confirms the desired bioactivity in HLA-DQ2 genotype patients," Dr Anderson said. "We expect the vaccine to enter Phase II trials within the next 10 months, and hope to demonstrate a dramatic reduction in the body's rejection of dietary gluten so patients can resume a normal diet and return to good health."

I really didn't like the last sentence. Gluten free diet can in most cases return people to good health also. It also stated that it is to have a reduction in reactions. So does that mean on some level there is autoimmunity still going on? I don't miss gluten filled food that bad.

cahill Collaborator
cahill
Posted

It seems to me that money would be better spent in trying to develop more sensitive tests for celiac and educational programs for doctors and the general population. It is Celiac Disease Awareness Month, or is it? I know I haven't seen any news blurbs about it.

I agree but then there would not be any money in it for the pharmaceutical companys would there. :angry:

The treatment for celiacs is a gluten free diet,the pharmaceutical companies can not make money off of that so, IMHO, celiacs does NOT get their support(money for research,better testing ,awareness campaigns,ect... ), instead they opt for something they can make money off of ( a vaccine )instead of what is in the best interest of the general population (awareness,better testing,information )

Pac Apprentice
Pac
Posted

I really didn't like the last sentence. Gluten free diet can in most cases return people to good health also. It also stated that it is to have a reduction in reactions. So does that mean on some level there is autoimmunity still going on? I don't miss gluten filled food that bad.

I don't like the last sentence either.

As for why they are developing the vaccine, they make that quite clear on their website:

"It has been predicted that 50-60% of affected patients will be diagnosed in developed countries by 2019, creating a potential pharmaceutical market worth US$8 billion."

etta694 Explorer
etta694
Posted

"The drug triggers the death of the cells that cause the damaging immune response,'' he said. ''By doing that you switch the immune reaction from a damaging one to a tolerant one.''"

I also wonder what else this affects if cells which are a normal part of our immune response are killed. What else are these cells responsible for (long term)? Its like taking out the squeaky hinge.. and then finding out the door falls off.

Edo Rookie
Edo
Posted

I agree with those who are skeptical. The vaccine wouldn't be for me anyway because I'm not DQ2. But either way, knowing what I now know about nutrition and our food system, even if I could eat gluten and processed foods and everything else, I still wouldn't. Even if they can guarantee zero autoimmune response and no other consequences from the vaccine, that doesn't mean there aren't plenty of other health consequences to eating a "normal" diet again. I think of celiac as forcing me back to a healthy, natural human diet, and away from the food system that is making people sick, celiac or otherwise. The vaccine is just feeding into the mentality that we should be fitted to the system, instead of the system being fitted to us. It makes a lot of dollars, but not a lot of sense.

Mack the Knife Explorer
Mack the Knife
Posted

These are some of the new stories thta have appeared in Australia leading up to this latest announcement:

Mack the Knife Explorer
Mack the Knife
Posted

And these just got posted up on Youtube:

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. Dakota01
      - Dakota01 commented on Scott Adams's article in Winter 2026 Issue
      1

      Are Gluten-Free Processed Foods Making You Sick? (+Video)

      This video is extremely informative and explains why I still get sick when I eat these so called gluten-free processed foods. I make every effort to stay away from all processed foods.
    2. Scott Adams
      0

      Why Celiac Diagnosis Still Takes Years—and How to Change That

    3. JoJo0611
      - JoJo0611 posted a topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      0

      Awaiting Biopsy results

      I have had my endoscopy this morning with biopsies. My consultant said that it looked like I did have coeliac disease from what he could see. I now have to wait 3 weeks for the biopsy results. Do I continue eating gluten till my follow appointment in three weeks.
    4. cristiana
      - cristiana replied to emzie's topic in Related Issues & Disorders
      1

      Stomach hurts with movement

      Hi @emzie and welcome to the forum. Perhaps could be residual inflammation and bloating that is causing sensitivity in that area. I was diagnosed with coeliac disease in 2013 and I remember some years ago my sister telling me around that time that she had a lady in her church, also a coeliac, who had real pain when she turned her torso in a certain...
    5. emzie
      - emzie posted a topic in Related Issues & Disorders
      1

      Stomach hurts with movement

      Hi! One of the usual symptoms I have with a gluten flare up has deviated a bit and I thought I'd search for advice/opinions here. Also to see if anyone goes through similar stuff. Monday all of a sudden I got really bad pain in my stomach (centre, right under the chest, where the duodenum would be located). I ended up having to throw up for 2 hours, my body...
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      132,455
    • Most Online (within 30 mins)
      7,748
    Suelle
    Newest Member
    Suelle
    Joined
  • Celiac.com Sponsor (A20):

  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • JoJo0611
      Awaiting Biopsy results

      By JoJo0611 · Posted

      I have had my endoscopy this morning with biopsies. My consultant said that it looked like I did have coeliac disease from what he could see. I now have to wait 3 weeks for the biopsy results. Do I continue eating gluten till my follow appointment in three weeks.  
    • cristiana
      Stomach hurts with movement

      By cristiana · Posted

      Hi @emzie and welcome to the forum. Perhaps could be residual inflammation and bloating that is causing sensitivity in that area.  I was diagnosed with coeliac disease in 2013 and I remember some years ago my sister telling me around that time that she had a lady in her church, also a coeliac, who  had real pain when she turned her torso in a certain direction whilst doing exercises, but otherwise was responding well to the gluten-free diet. As far as I know is still the picture of health. I often end up with pain in various parts of my gut if I eat too much rich food or certain types of fibre (for some reasons walnuts make my gut hurt, and rice cakes!) and and as a rule, the pain usually hangs around for a number of days, maybe up to a week.   When I bend over or turn, I can feel it.  I think this is actually due to my other diagnosis of IBS, for years I thought I had a rumbling appendix but I think it must have just been IBS.  Reading the experiences of other sufferers, it seems quite typical.  Sensitized gut, build up of gas - it stands to reason that the extra pressure of turning can increase the pain. When I am glutened I get a burning, gnawing pain in my stomach on and off for some days - it isn't constant, but it can take up a few hours of the day.  I believe this to be gastritis, but it seems to hurt irrespective of movement.   Anyway, you are doing the right thing to seek a professional opinion, though, so do let us know how you get on.   Meanwhile, might I suggest you drink peppermint tea, or try slices of fresh ginger in hot water? A lot of IBS sufferers say the former is very helpful in relieving cramps, etc, and the latter is very soothing on the stomach. Cristiana
    • emzie
      Stomach hurts with movement

      By emzie · Posted

      Hi! One of the usual symptoms I have with a gluten flare up has deviated a bit and I thought I'd search for advice/opinions here. Also to see if anyone goes through similar stuff. Monday all of a sudden I got really bad pain in my stomach (centre, right under the chest, where the duodenum would be located). I ended up having to throw up for 2 hours, my body was trying to get rid of something from all sides and it was just horrible. Since then I havent been nauseous anymore at all, but the pain has stayed and it always worsens the moment i start moving. The more I move the more it hurts, and when i rest longer it seems to dissapear (no movement). I've had this before, but years ago I think around when I first got diagnosed with coeliac, where each time I moved, my stomach would hurt, to the point where I went to the ER because doctors got freaked out. That only lasted 1 night though, and Now it's already wednesday, so 3 days since then, but the pain persists and remains leveled. it doesn't get crazy intense, but it's still uncomfortable to the point I cant really go out because Im afraid itll turn into a giant flare up again. I couldn't think of where I could possibly have been glutened at this bad of a level and why it hasn't passed yet. I went to the GP, and as long as I have no fever and the pain isnt insane then its fine which I havent had yet. Tomorrow im also seeing a gastroenterologist specialized in IBS and coeliac for the first time finally in years, but I thought I'd ask on here anyway because it still hasnt dissapeared. It also hurts when someone presses on it. Maybe it's just really inflamed/irritated. I'm just frustrated because I'm missing out on my uni lectures and I do a sports bachelor, so I can't get behind on stuff & next to that i'm also going to go to the beach with my boyfriend's family this weekend: ( 
    • Flash1970
      Shingles - Could It Be Related to Gluten/ Celiac

      By Flash1970 · Posted

      Hi. So sorry to hear about your shingles. There is a lidocaine cream that you can get at Walmart that will help numb the pain.  That's what I used for mine. It can't be put near your eyes or in your ears. I hope your doctor gave you valacyclovir which is an antiviral.  It does lessen the symptoms. If it is in your eyes,  see an ophthalmologist.  They have an antiviral eye drop that can be prescribed.  Shingles in the eye could cause blindness.  I was unsure whether you have celiac or not.  If you do,  follow the diet.  I believe that extra stress on your body does affect everything. Shingles can recur. If you start getting the warning signs of nerves tingling,  see the dr and start taking the valacyclovir to prevent a breakout. If I sound technical,  I am a retired pharmacist. 
    • Scott Adams
      celiac disease and braces

      By Scott Adams · Posted

      You are right to be proactive, as research does indicate that individuals with celiac disease can have a higher predisposition to enamel defects, cavities, and periodontal issues, even with excellent oral hygiene. While many people with celiac successfully undergo orthodontic treatment without complication, your caution is valid. It may be beneficial to seek a consultation with an orthodontist who is familiar with managing patients with autoimmune conditions or who is willing to collaborate with your daughter's gastroenterologist or a periodontist. They can perform a thorough assessment of her current oral health, discuss your specific concerns about recession and decay, and create a tailored hygiene plan. This second opinion could provide a clearer risk-benefit analysis, helping you decide if addressing the cosmetic concern of the lower teeth is worth the potential risks for your daughter, especially if they are not currently affecting function or her confidence. 
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.