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Recent Activity
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- knitty kitty replied to Zuma888's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease8Hypothetical question about antibodies
You have one gene for Celiac. You have a second autoimmune disease, Hashimoto's thyroiditis, which is frequently found at a higher rate with Celiac. HLA genes carry autoimmune disease genes like Celiac and Hashimoto's and diabetes and others. You have Celiac symptoms of reacting after gluten. You said "I am however still suffering from the effects... -
- Zuma888 replied to Zuma888's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease8Hypothetical question about antibodies
Thanks @Scott Adams! I guess my question now is: do the celiacs who can get away with regular contamination without villi damage as you mentioned have to be strict about cross-contamination ? -
- Zuma888 replied to Zuma888's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease8
Hypothetical question about antibodies
Thank you very much @knitty kitty! I'm glad you brought up the point about histamine. I have been taking an antihistamine after meals where I don't feel so good and never knew why it helped so much. At first I thought I might have a food allergy, but I recently did a food allergy test and I actually have ZERO food allergies. Regarding your last... -
- Zuma888 commented on Jefferson Adams's article in Diagnosis, Testing & Treatment22
How Refining the Gluten Challenge May Help Improve Diagnostics for Celiac Disease
Thank you @knitty kitty! Do you take these supplements only after gluten exposure or all the time? If it is the latter, then why do you need to do so since there shouldn't be an autoimmune response going on?- celiac disease
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- knitty kitty commented on Jefferson Adams's article in Diagnosis, Testing & Treatment22
How Refining the Gluten Challenge May Help Improve Diagnostics for Celiac Disease
Histamine is released by mast cells as a part of the autoimmune response. Histamine also happens to be a neurotransmitter that causes alertness, hence the insomnia. You know that cup of coffee in the morning so you can wake up? Releases histamine. Diamine Oxidase (DAO) enzymes help break down histamine, as do Vitamin B12 Cobalamine and Vitamin C....- 1
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By knitty kitty · Posted
You have one gene for Celiac. You have a second autoimmune disease, Hashimoto's thyroiditis, which is frequently found at a higher rate with Celiac. HLA genes carry autoimmune disease genes like Celiac and Hashimoto's and diabetes and others. You have Celiac symptoms of reacting after gluten. You said "I am however still suffering from the effects of the gluten challenge (food sensitivities, slight brain fog, weird stool, fatigue, swollen thyroid, bodyaches)." And your anti-thyroid antibodies increase after gluten exposure. While tTg IgA does not directly attack the thyroid, gluten exposure does trigger the immune system to produce antibodies against the thyroid in genetically predisposed individuals. You did not eat sufficient gluten (10 grams of gluten per day for two weeks minimum) to raise the autoimmune antibodies to the point they can be measured in the blood, so your blood tests may well be inaccurate. You could choose to continue the gluten challenge of 10 grams a day for at least two weeks and get retested. At the very least, you know that gluten is harmful to your thyroid, and because you are genetically predisposed to Celiac disease, a strict gluten free diet would be beneficial for your overall health. -
Thanks @Scott Adams! I guess my question now is: do the celiacs who can get away with regular contamination without villi damage as you mentioned have to be strict about cross-contamination ?
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Thank you very much @knitty kitty! I'm glad you brought up the point about histamine. I have been taking an antihistamine after meals where I don't feel so good and never knew why it helped so much. At first I thought I might have a food allergy, but I recently did a food allergy test and I actually have ZERO food allergies. Regarding your last point about the stages of grief, are you saying it's likely that I have celiac? I have Hashimoto's BTW and I know for sure that gluten causes an autoimmune response to my thyroid as my anti-TPO and anti-Tg go up and my throat feels swollen. Could the symptoms be due to that autoimmune response?
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By knitty kitty · Posted
@Zuma888, The antibodies produced in response to gluten are made in the intestines. When the body is provoked sufficiently, the antibodies overflow out of the intestines and into the blood stream. Once in the blood stream, the antibodies can be measured with tTg IgA tests. Three grams of gluten per day for two weeks minimum is enough gluten to make you feel the symptoms of having been glutened, but the antibodies are not in sufficient quantity to be measured in the blood. Ten grams of gluten per day for a minimum of two weeks is required to get the anti gluten antibodies at a high enough level in the blood stream to be measured by tTg IgA tests. So, no, occasional cross contamination or (heaven forbid) intentional cheat days will not be sufficient for tTg IgA testing. You will still be making antibodies which will still be causing inflammation and damage to the intestines and body. Histamine is released as part of the immune response to gluten. High histamine levels lead to food sensitivities, brain fog, and body aches. The damage done to the gastrointestinal tract affects the absorption of essential vitamins and minerals. Malabsorption of fats can cause changes in stools. Insufficient absorption of vitamins and minerals can cause damage to other organs like the thyroid if it can't get enough Selenium, iodine, iron, zinc, and Thiamine. Brain fog and fatigue can be caused by low Thiamine and other B Complex vitamins. Vitamin D is needed to regulate the immune system. One gene is all that's needed to develop Celiac disease. I know a Celiac diagnosis is a change that can be difficult to get your head around. Many people go through the five stages of grief. One stage is "bargaining". Sounds like you're stuck there. Every little cheat counts to your detriment. But sticking to a gluten free diet, makes every meal a success. Read the comments below the article... Best wishes! Keep us posted on your progress! -
By Scott Adams · Posted
No, I would not say this at all. If you were diagnosed with celiac disease and were gluten-free for a while, you could have gone into remission. Everyone's body is different, and some celiacs may be able to get regular contamination and not end up with damaged villi and positive antibody tests, while others who ingest tiny amounts will relapse and have full blown symptoms and flattened villi. Only a full gluten challenge would reveal where you are at this point. Here is more info about how to do a gluten challenge for a celiac disease blood panel, or for an endoscopy: and this recent study recommends 4-6 slices of wheat bread per day:
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